Trimix while on blood thinners like Apixaban?

Melody68 · 2025-03-19T15:55:42-0500

Hey guys - I'm 69 and have been on TE for about a year, love it.

I had a TIA in December and was recently put on a blood thinner / anti-coagulant being 5 mg Apixaban (Eliquis) twice a day, permanently.

I saw a urologist a few days ago about beginning Trimix. There's a $300 fee payable before undergoing tests to see if I qualify. He said there is no contraindication with Apixaban and Trimix.

Some past posts suggest, however, that caution is in order. The consensus is that it should be "okay", but of course I don't want to risk $300 if suddenly it's not. The fear is that a patient might bleed (from the injection I guess) and end up with a penile hematoma or increased risk of scarring leading to Peyronie's disease.

Is that concern irrational? You would think that with a tiny 30 gauge needle, it would be pretty tough to create a bleed. Would it make sense to only inject after the Apixaban has been in your system at least 8-10 hours and is thus getting weaker?

I'd love to hear from others in a similar situation, and how things have worked out ...

Nelson Vergel · 2025-03-19T22:33:59-0500

Melody68 said:
Is that concern irrational? You would think that with a tiny 30 gauge needle, it would be pretty tough to create a bleed. Would it make sense to only inject after the Apixaban has been in your system at least 8-10 hours and is thus getting weaker?

You may get bruises. Make sure that you massage the injection site hard with your thumb.

Penis bruises take around 3 weeks to disappear. If you get one, massage the area with your thumb while you are showering. Some guys use arnica oil with success.

"Arnica oil is a popular homeopathic and herbal preparation traditionally used to help reduce the appearance of bruises and soothe minor aches or muscle discomfort. It is derived from the yellow-orange flowers of the Arnica montana plant, which contain active compounds (such as sesquiterpene lactones) believed to have anti-inflammatory properties."

Nelson Vergel · 2025-03-19T22:35:58-0500

By the way, Apixaban has an average half-life of about 12 hours in individuals with normal kidney function. As a rule of thumb, most medications are considered effectively eliminated from the body after about five half-lives. Here’s how that applies to Apixaban:

Half-life in healthy adults: ~12 hours
Time to near-complete elimination: 5 × 12 hours = ~60 hours (about 2.5 days)

Nelson Vergel · 2025-03-19T22:37:24-0500

N

Thread 'Blood Thinner and TriMix?'

Oct 12, 2017

Just wondering if it's possible to get a script for TriMix while being on a blood thinner? Unfortunately I have to take Xarelto. I'm not a bleeder despite being on Xarelto, I shave my face with a blade and if I get a small cut on my face or finger, etc, it does stop pretty quickly. I ask because I have completed the paperwork for Defy for a Trimix consult, and was just going to schedule a local physical, but paused here to ask you all...I don't want to spend more money if Defy is going to say "no way!". Thanks