So I have recent experience with pt-141 and trimix. Just turned 60, recently separated and "dating" again, and since I was a teenager I've had lifelong "performance anxiety", but only the first time with a new woman, and once I've "proven myself", I'm usually good, sometimes using sildenafil for an extra kick. Obviously, erections aren't like when I was 28, but still get hard nocternal erections.
First experience with a new woman in years, a little younger than me (53), and I really thought pt-141, maybe with a low does of sildenafil would be my solution. My experience with it is almost EXACTLY the same as
@VacationMan ... lower does taking 8 hours to kick in, initially thought it wasn't working but was waking up with rock hard erections ALL night. Working up to 2mg I noticed it was kicking in more at 3-4 hours, a little nausea but not bad, but never would go above that dose. As good as it is, even with low does sildenafil, the slightest bit of anxiety is just enough to defeat it! Damn... first encounter, had to use my goto "excuse" but didn't want to fail 2nd time around... had a month or so before we were going to meet again, so... did research on Trimix.
Found two clinical studies documenting it's short term use for performance anxiety, with excellent results, so I did an online consult, and got a script for a mixture that was 20-30-1. They suggested dose between 0.1 and 0.5 ml. My biggest concern was priapism, so I started at 0.05... produced a solid 2.5 hour erection, even after ejaculating and vigorous jog... later found some suggestions to start at that dose, and work up by 0.02 ml until you find an ideal dose. Next meetup was great, rock hard, no worries, made her orgasm multiple times. So my trimix situation was similar to
@DFL with younger women. Performance anxiety gone... but seriously, this was so good, even at a low dose, that I may use it from time to time. We shall see. Again, my main issue is psychogenic ED, so obviously for organic it will be a very different dosage / usage.