A study duscussed at the Endo 2019 conference showed significant long term weight loss in men treated with testosterone therapy. While it's preferable to lose weight through diet and exercise, the long term success rate for thes changes are low. So having a pharmacological treatment which provides other benefits is helpful. The news report says:
For this current study, Haider and his colleagues followed 805 patients with hypogonadism who were, on average, in their late fifties to mid-sixties. The 462 (57.4%) patients with obesity were given the choice whether to be treated with long-term testosterone therapy with Testosterone Undecanoate 1,000 mg every 12 weeks. Of these, 273 opted to receive testosterone, and the 189 who declined treatment served as controls. “We had many reactions, and most were positive,” Haider says. “[Seventeen] patients who at first refused treatment changed their mind after several years during which they encountered major adverse cardiovascular events and were strongly advised by their cardiologist to start the treatment.”
Over 10 years, the testosterone-treated men lost 20.3% of their baseline weight (50.5 lb; 22.9 kg); their waist circumference dropped by 12.5 cm (4.9 in). BMI decreased by 7.3 kg/m2, and the waist-to-height ratio decreased by 0.07. By contrast, the untreated men gained 3.9% of their baseline weight (3.2 kg; 7.1 lb), and their waist size increased by 4.6 cm (1.8 in). In this group, BMI increased by 0.9 kg/m2, and waist-to-height ratio increased by 0.03. During this time, 12 (4.4%) men in the testosterone group died, while in the untreated control group, 57 deaths (30.2%), 47 myocardial infarctions (24.9%) and 44 strokes (23.3%) occurred.
Haider says they saw gastroenterological patients who reported remissions in their Crohn’s disease once starting on testosterone therapy. Some of their patients with hypogonadism and type 2 diabetes receiving standard diabetes treatment went into remission and did not need their diabetes medication anymore.
For this current study, Haider and his colleagues followed 805 patients with hypogonadism who were, on average, in their late fifties to mid-sixties. The 462 (57.4%) patients with obesity were given the choice whether to be treated with long-term testosterone therapy with Testosterone Undecanoate 1,000 mg every 12 weeks. Of these, 273 opted to receive testosterone, and the 189 who declined treatment served as controls. “We had many reactions, and most were positive,” Haider says. “[Seventeen] patients who at first refused treatment changed their mind after several years during which they encountered major adverse cardiovascular events and were strongly advised by their cardiologist to start the treatment.”
Over 10 years, the testosterone-treated men lost 20.3% of their baseline weight (50.5 lb; 22.9 kg); their waist circumference dropped by 12.5 cm (4.9 in). BMI decreased by 7.3 kg/m2, and the waist-to-height ratio decreased by 0.07. By contrast, the untreated men gained 3.9% of their baseline weight (3.2 kg; 7.1 lb), and their waist size increased by 4.6 cm (1.8 in). In this group, BMI increased by 0.9 kg/m2, and waist-to-height ratio increased by 0.03. During this time, 12 (4.4%) men in the testosterone group died, while in the untreated control group, 57 deaths (30.2%), 47 myocardial infarctions (24.9%) and 44 strokes (23.3%) occurred.
Haider says they saw gastroenterological patients who reported remissions in their Crohn’s disease once starting on testosterone therapy. Some of their patients with hypogonadism and type 2 diabetes receiving standard diabetes treatment went into remission and did not need their diabetes medication anymore.
