Too much hcg?

2500IU twice a week is what fertility docs prescribe. I had a fertility doc try to prescribe that dose to me once.

The dose recommended by Merck, the manufacturer of Pregnyl, is all over the place:

"Selected cases of hypogonadotropic hypogonadism in males.

1. 500 to 1000 USP units 3 times a week for 3 weeks, followed by the same dose twice a week for 3weeks.

2. 4000 USP units 3 times weekly for 6 to 9 months, following which the dosage may be reduced to2000 USP units 3 times weekly for an additional 3 months."

From here: https://www.merck.com/product/usa/pi_circulars/p/pregnyl/pregnyl_pi.pdf
 
Re-ride's posts reflect he is a bright guy...I'm almost certain he is being sarcastic (as opposed to literal) with the sublingual HCG "guaranteed no overdose" comment...witty.
 
Xr88 - if FERTILITY is your main priority, while also balancing not creating too many issues with E2, then I would suggest 500iu BIW, perhaps 500iu TIW at most (monitor semen analyses to guide and indicate effectiveness).
 
IMO any HCG injection over 350 iu is unnecessary and can only got to increase intratesticular E2 which an AI is generally unable to control.

There are only so many leydig receptors on the testicles and any over dosing of HCG isn't going to result in any more production of Testosterone.

Remember guys, LH (or HCG as its analog) is primarily responsible for Testosterone production. Semen is produced by FSH and not LH.

TRT via the negative feedback loop shuts down both LH/FSH and as a result the testes don't function anymore which in and of itself can cause a bunch of other problems.

HCG keeps the testes functioning so there will be "some" semen production by the mere fact that the testes are functioning again but one really needs to stimulate the FSH receptors to increase semen production to optimal levels.
 
Dr Saya is on the forum responding to a thread I had in regard to that exact thing, Gene...aromatization in the testes is tougher to manage as that environment is less acted upon by an AI. (not quoting the Dr).

I've felt for awhile now that any dose above what's necessary to keep the testes simply alive, is just a waste. Whether that's daily or EOD of 250iu, can be debated and again Dr Saya had a great though small case-study on HCG dosing a few months ago that is posted on the forum.
 
^^^^This is total bullshit.

Fact: The HCG molecule is to large to be able to enter the blood stream without an injection.

Period.

Hi Gene, I'm no endo but I did spend a virtual night in Bogata. I don't regret the spelling error. Springtime in the Carpathians, oh yeah! Y'all check your tickets carefully now unless u be shopping for waders to go noodiln in the Red River.
 
Hi Gene, I'm no endo but I did spend a virtual night in Bogata. I don't regret the spelling error. Springtime in the Carpathians, oh yeah! Y'all check your tickets carefully now unless u be shopping for waders to go noodiln in the Red River.

Re-Ride you're making my "bright guy" comment above look less credible LOL
 

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