The Ultimate Guide to Testosterone, explained by the #1 Urologist Treating Low T

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madman

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In this episode, Dr. Rena Malik, MD engages in an enlightening conversation with Dr. Abraham Morgentaler from Harvard Medical School about the complexities of testosterone health. They explore the intricacies of Clomid treatments, delve into the mechanisms behind testosterone production, and consider environmental factors affecting younger men's hormone levels. The episode further discusses the challenges of diagnosing and treating low testosterone, the influence of cultural and technological shifts on intimacy, and misconceptions around testosterone therapy and prostate cancer risk. Listeners will come away with a deeper understanding of testosterone health, its impact on quality of life, and the personalized approach needed in treatment.

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Chapters

00:00:00 Introduction
00:09:35 Symptoms of low testosterone
00:12:22 Regulating Sexual Behavior
00:17:01 Why is Testosterone Controversial?
00:20:37 Is testosterone is safe and effective?
00:23:40 Testosterone Treatment: No Increased Cancer Risk Found
00:34:14 Optimal diagnosis of test low testosterone
00:36:46 How to measure testosterone
00:44:33 Estradiol
00:49:34 Patient-Focused Care: Thorough Communication and Support
00:51:19 Optimal age-based testosterone levels
01:08:12 Is supraphysiologic testosterone harmful?
01:10:20 Benefits of testosterone

Unlocking the Truth About Testosterone: Insights from Experts
Testosterone plays a critical role in male health, affecting everything from sexual drive to muscle mass. Yet, despite its importance, testosterone therapy remains a controversial topic in medicine, often misunderstood due to widespread myths and fears.
In a conversation between Dr. Reena Malik, a urologist and pelvic surgeon, and Dr. Abraham Morgentaler, a leading expert on testosterone from Harvard Medical School, they explored the realities surrounding testosterone therapy, including its benefits, the myths about its risks, and the challenges men face when trying to access it.

The Benefits of Testosterone​

Testosterone is essential for male health, influencing many bodily functions beyond sexual health. Dr. Morgentaler shared how testosterone directly impacts mood, energy levels, muscle mass, bone density, and even cognitive function. Symptoms of low testosterone can include fatigue, lack of motivation, brain fog, reduced libido, and difficulty building muscle. These symptoms can severely affect a man’s quality of life.
One fascinating insight Dr. Morgentaler shared came from his early research with lizards. By implanting testosterone into the brains of castrated male lizards, he found that their sexual behavior was restored, reinforcing that testosterone is a powerful hormone with significant effects on behavior.

Myths About Testosterone Therapy​

One of the longest-standing myths about testosterone is that it causes prostate cancer. This belief originated in the 1940s when doctors found that removing testosterone in prostate cancer patients helped shrink tumors. For decades, this led to the fear that giving testosterone to men could trigger cancer. However, Dr. Morgentaler emphasized that modern research shows no evidence of this. The largest-ever study on testosterone, the Traverse trial, involving over 5,000 men, showed no increase in prostate cancer, heart disease, or stroke among those receiving testosterone compared to those given a placebo.

Why Many Doctors Hesitate to Prescribe Testosterone​

Despite solid evidence that testosterone therapy is safe and beneficial, many doctors are still reluctant to prescribe it. This hesitation often stems from outdated beliefs, fear of malpractice, or a lack of experience in managing testosterone therapy. As Dr. Malik and Dr. Morgentaler pointed out, primary care physicians and even some urologists shy away from prescribing testosterone because of these misconceptions.
In some cities, this leaves men with few options other than visiting testosterone clinics, which some traditional doctors view as disreputable. However, as Dr. Morgentaler noted, many of these clinics provide a vital service to men who are suffering from the debilitating effects of low testosterone.

The Future of Testosterone Therapy​

One of the key takeaways from this discussion is the need for education and awareness. As more research supports the benefits of testosterone and dispels the myths, doctors and patients alike need to understand that low testosterone is a treatable condition that can significantly improve a man’s quality of life.
If you suspect you have low testosterone, it’s important to find a healthcare provider knowledgeable about hormone health. Proper diagnosis involves measuring both total and free testosterone levels, as well as considering other factors such as SHBG (sex hormone-binding globulin) levels and symptoms.

Conclusion​

Testosterone therapy is often misunderstood, but the scientific community is slowly unraveling the truth. As Dr. Morgentaler highlighted, testosterone doesn’t deserve its bad reputation. It’s time to move beyond the myths and recognize the profound impact it can have on men’s health.
 
Last edited by a moderator:
Defy Medical TRT clinic doctor
1200-1500 trough TT BRUH with sky-high FT BRUH raging libido, bonkers erections to boot!

LMFAO!

* what's important to understand though is that the concept of testosterone therapy in theory is designed to replicate youthful levels of testosterone to help people who are deficient in this hormone, the goal isn't to make them into supermen and the real question is why do people want to go above normal if at all, much of the concept of treating up lets say a 1000 let's say our normal upper limit, in the anti-aging community or age management community there are some people who believe the there's an optimal level of testosterone that may be 1200 or 1500 or even I've heard 1800 and the basis for that is WEAK!



00:51:19 Optimal age-based testosterone levels

01:10:12 The dangers of supraphysiologic testosterone?
 

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IMPACT STATEMENT

Measurement of free hormone (FH) concentrations in biological samples presents a challenge to the clinical laboratory. FH concentrations are generally very low, requiring use of sensitive and specific techniques. Furthermore, special attention must be placed on the equilibrium between free and protein-bound hormone when separating and analyzing in vitro. This review will enhance the readers’ understanding of the current state of mass spectrometry-based methods for the measurement of FHs. The advantages and disadvantages of different separation techniques and sample preparation methods are discussed, as well as clinical conditions in which measurement of FH is warranted.






*The agreement among IA and among ED-LC-MS/MS assays was close. However, FT concentrations obtained by IAs were in average 6 times lower compared to the ED-LC-MS/MS methods

*Results estimated using the Vermeulen equation overestimated FT in average by 15% compared to the ED-LC-MS/MS methods and by over 6 times compared to IAs




*Preliminary findings of the CSP interlaboratory comparison study found large variability among participating assays. The agreement among IA and among ED-LC-MS/MS assays was close. However, FT concentrations obtained by IAs were in average 6 times lower compared to the ED-LC-MS/MS methods. Results estimated using the Vermeulen equation overestimated FT in average by 15% compared to the ED-LC-MS/MS methods and by over 6 times compared to IAs.






*The data from the present analyses suggest that the interaction of the three sex hormones with their cognate binding proteins is highly complex and dynamic and influenced by their relative circulating concentrations. Therefore, models of testosterones binding to SHBG, based on the assumption of fixed apparent binding affinity of sex hormones with SHBG, that do not consider the influence of estradiol and dihydrotestosterone on the free testosterone fraction are unlikely to provide accurate estimates of free testosterone fraction.




* Collectively, these data highlight the non-linear, concentration-dependent modulation of testosterone repartitioning into bound and free fractions by each of the three sex hormones.

*Our finding that the estradiol, DHT, and testosterone interact to alter free testosterone fraction non-linearly suggests that in men with hypogonadism who are receiving TRT, free testosterone levels should be measured using a reliable method to guide the dose titration. The models that do not consider changes in estradiol and DHT concentrations are susceptible to error in estimating free testosterone concentrations.

*These data suggest that changes in estradiol and dihydrotestosterone concentrations should be considered in evaluating response to testosterone treatment because of their differential influence on free testosterone concentrations in addition to their ability to exert other independent biologic effects. Because of these complex interactions between various sex hormones as well as other ligands with sex hormone binding globulin, direct measurements of free testosterone using a reliable assay, such as the equilibrium dialysis method, may be a superior marker of testosterone’s treatment effect.
 
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