Testosterone/Estradiol Ratio

[JA Battle]

(a) 17‐α‐estradiol (17aE2) is a relatively “non‐feminizing” estrogen which shows reduced activation of classical estrogen receptors compared with 17‐β‐estradiol (Anstead et al., 1997). Harrison et al. (2014) reported that in UM‐HET3 mice fed 4.8 mg 17aE2/kg (4.8 ppm) diet from 10 months of age, median male lifespans increased 12% (p = 0.0012, pooled across the three sites), while 17aE2 did not alter female lifespan. Strong et al. (2016) showed that using a threefold higher dose (14.4 ppm) from 10 months of age, pooled median male lifespans increased 19% (p < 0.001); the 90% lifespan increased 12%, but females still did not benefit. Thus, only males were tested in the present study. To determine whether 17aE2 treatment is effective when initiated in older mice, males were treated beginning at 16 or 20 months of age, choosing middle age, and early old age before many natural deaths.

I feel like it’s crazy that I inject estrogen but I’m going in for 24mcg estradiol valerate daily bloodwork on Monday. I don’t think it moved my e2 level much. I think I still have low e symptoms. But before I change dosage I must know for sure. I’m testing trough and 5 hours after injection to see if there is any fluctuation with such a tiny dose of the valerate ester. Valerate has a shorter half life than enanthate but longer half life that propionate.

 

[Cataceous]

I feel like it’s crazy that I inject estrogen but I’m going in for 24mcg estradiol valerate daily bloodwork on Monday. ...

I wouldn't hesitate to do this if I had inadequate aromatization. A lot better control than trying to get it indirectly through hCG.

 

[Match]

Isso era geralmente 70 mcg EOD, cerca de um quarto de miligrama por semana.

T 637 e Estradiol 32. Penso usar Anastrozol 0,5mg por semana. O que acha? SHBG meio alto 62 nomol / l (nao sei que relalçao tem com Estradiol)

 

[Cataceous]

T 637 e Estradiol 32. Penso usar Anastrozol 0,05mg por semana. O que acha? SHBG meio alto 62 nomol/l (nao sei que relalçao tem com Estradiol)
T 637 and Estradiol 32. I plan to use Anastrozole 0.05mg per week. What do you think? SHBG medium high 62 nomol / l (I don't know what relationship it has with Estradiol)

I would not use an aromatase inhibitor. Testosterone and estradiol are well balanced. If you're having symptoms of low testosterone due to your high SHBG then you should look into Natesto. This product supplements your existing testosterone and it might lower SHBG a little.

 

[Match]

Natesto é associado de T em gel nasal, ok? 11mg, me parece.
Mas requer receita médica, ok?
Quanto ao SHBG, reduzindo um pouco o Estradiol com IA não reduz tb SHBG?

 

[Cataceous]

Natesto is associated with T in nasal gel, ok? 11mg, it seems to me.
But it requires a prescription, okay?
As for SHBG, reducing Estradiol with AI a little does not reduce tb SHBG?

Yes, Natesto does need a prescription. I would not attempt to use an AI to manage SHBG, particularly when starting from a healthy normal level of estradiol. At least for me, modest changes in estradiol don't have much effect. Only when estradiol was undetectable did my SHBG also crash.

 

[Match]

OK. É que Estradiol tb talvez um pouco acima. T / E 637/32 = 19
Mandei já 0,5mg de Anastrozol e manter só uma vez por semana, pra ver o que ocorre

 

[Match]

Sim, o Natesto precisa de receita. Eu não tentaria usar um AI para controlar SHBG, particularmente quando iniciando com um nível normal de estradiol saudável. Pelo menos para mim, mudanças modestas no estradiol não têm muito efeito. Somente quando o estradiol era indetectável, meu SHBG também travou.

Parei com o Anastrazol. A TF parece ter origem no alto SHBG. Sabe de artigos, topicos a respeito, pois a maioria parece ter baixo e nao alto SHBG?

 

[Dialingitin]

Not much action in this thread for over a year! But it’s a good one as I dial in my protocol. I just got my ultra-sensitive E2 back and it’s sitting at 63. TT at 760 ng/dL and free at 169 at pg/mL, measured at trough. All other markers look great, including SHBG (20 with range of 10-50). This was a Quest panel. Interestingly, about three weeks ago total T was measured at 1,000 with Labcorp.

I am 100mg/week Test E (sub q). I have felt great on 100mg. Losing weight consistently, gym time is great, emotions/energy all very stable.

My E2 ratio puts me at 12 using my latest total T. I am not concerned and did this Quest panel as more of a check-in and to establish a good baseline. However, I’m curious if this is something I should more closely monitor? I continue to lose body fat/build muscle in my question for functional body recomp. Are there symptoms I should be on the lookout for?

Thanks in advance!

 

[Bbkb8311]

Not much action in this thread for over a year! But it’s a good one as I dial in my protocol. I just got my ultra-sensitive E2 back and it’s sitting at 63. TT at 760 ng/dL and free at 169 at pg/mL, measured at trough. All other markers look great, including SHBG (20 with range of 10-50). This was a Quest panel. Interestingly, about three weeks ago total T was measured at 1,000 with Labcorp.

I am 100mg/week Test E (sub q). I have felt great on 100mg. Losing weight consistently, gym time is great, emotions/energy all very stable.

My E2 ratio puts me at 12 using my latest total T. I am not concerned and did this Quest panel as more of a check-in and to establish a good baseline. However, I’m curious if this is something I should more closely monitor? I continue to lose body fat/build muscle in my question for functional body recomp. Are there symptoms I should be on the lookout for?

Thanks in advance!

Would love some help. Test at 770. Estrogen at 7. Taking Enclomaphine. Not Clomid. No AI.

 

[Systemlord]

Would love some help. Test at 770. Estrogen at 7. Taking Enclomaphine. Not Clomid. No AI.

The majority of estrogen is made via aromatase in fat tissue. Total T is a function of SHBG. You never mention what your SHBG levels are or post your Free T results.

It’s not uncommon to see a low estrogen value alongside a low Free T value.

 

[Bbkb8311]

The majority of estrogen is made via aromatase in fat tissue. Total T is a function of SHBG. You never mention what your SHBG levels are or post your Free T results.

It’s not uncommon to see a low estrogen value alongside a low Free T value.

Free t was marked flagged high. I can check.

 

[Bbkb8311]

Free t was marked flagged high. Over 100. I can check.

Posting now.

 

[Bbkb8311]

Labs. November. 2 weeks on enclo. 6.25 EOD

Have since moved to 12.5 every 4th day. Got floaters on EOD.

 

[Bbkb8311]

Appreciate the help.

I’m 49. 6’4” 250. Lifetime natty. Major gym rat.

 

[Nelson Vergel]

Does anyone know what men with naturally high levels of testosterone have for an estradiol level?

Read this and watch my video:

How to Predict Estradiol and DHT at Different Testosterone Doses

I was able to come up with a table using the predictive model equation derived from data in this study: The Effects of Injected Testosterone Dose and Age on the Conversion of Testosterone to Estradiol and Dihydrotestosterone in Young and Older Men Summary This video discusses a research paper...

www.excelmale.com

 

[Nelson Vergel]

I found this concerning Estradiol.

• When researchers monitored the estrogen levels of 501 men with chronic heart failure, men with estradiol (the most "potent" form of estrogen) in the normal range (between 21.80 pg/ml and 30.11 pg/ml) had the fewest deaths during a three-year period. Men with the highest levels (above 37.99) had 133 percent more deaths during the same period. However, the men with the lowest estrogen levels (below 12.90) fared the worst as they experienced 317% more deaths.
  
  Here's a list of the median estradiol levels by age, as established by the authors of a study that appeared in the journal Clinical Endocrinology:
  • Age 2-29: 28.0 pg/ml
  • Age 30-39: 25.7 pg/ml
  • Age 40-49: 24.7 pg/ml
  • Age 50-59: 22.1 pg/ml
  • Age 60-69: 21.5 pg/ml
  • Age 70-80: 21.9 pg/ml
  Furthermore, as you get older, SHBG levels rise and bind up more hormone, so while estrogen levels might appear "normal," your amount of "free" estrogen might be too low. Ideally, both SHBG and estrogen blood levels should fall in the mid-range of normal values so that you can get an actual snapshot of your estrogen situation.
  
  
  

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This sample was from men with an average of 339 ng per dL of testosterone and with prior history of cardiovascular issues.