Testosterone and Anastrozole starting dose for ED injections

[murrayh]

yea agreed thats where my idea is but having a hard time feeling good trying to get there. What were your labs like on that crazy protocol did you ever crash your e2

 

[optimizely]

Yes I’ve crashed it lol. Lowest it had gotten was 6. I operate so much better on a lower estrogen level however with my low SHBG so I actually felt fine. Just surprising to see that on a blood test.

 

[murrayh]

interesting that has been my theory on why I haven't felt good is that i really need to be much lower e2 wise than I had thought. Maybe that's the key.

 

[optimizely]

I am beginning to think that is the biggest factor in feeling good when having such low SHBG

 

[Vince Carter]

With low SHBG youre on what I think is the right track, by the numbers, you can look crashed E, when you're not and that's due to the Free Estrogen you have. Notice your Free T is over range, you can likewise expect Free Estrogen to be in a similar position. I've been working towards E mirroring the SHBG number, maybe a little less, or at least LC/MS/MS being under 20.
I am honestly doing the best I have been on TRT with my LC/MS/MS in the single digits, I think 6 was my last test, and SHBG was 12. Free Estradiol 0.18, lab range is <0.45, I'm doing Cyp @ 16mg/D which has been placing my Free T at the lab range.

I also have to use Exemestane/Aromasin @ 12.5mg EOD. I had been using Anastrozole @ .25mg EOD which just wasn't quite enough so I worked with my Dr to try a different approach and its been this that has done better for me with E.

 

[Vince Carter]

look at page 3 here with my latest labs:

I am always hot: Is this a high estradiol symptom?

 

[murrayh]

look at page 3 here with my latest labs:

I am always hot: Is this a high estradiol symptom?

Crazy that it took your E to get that low to feel good. I think I have finally figured out why I have been dealing with constant headaches, brain fog and feeling mediocre the past 6 months on TRT. My E non-sensitive (didn't know any better) prior to starting TRT was 5. I've contemplated quitting TRT quite a few times because I mostly felt worse on it and couldn't figure out why as labs looked ok E wise. Going to try and maintain a little lower E and see how I feel.

 

[optimizely]

With low SHBG youre on what I think is the right track, by the numbers, you can look crashed E, when you're not and that's due to the Free Estrogen you have. Notice your Free T is over range, you can likewise expect Free Estrogen to be in a similar position. I've been working towards E mirroring the SHBG number, maybe a little less, or at least LC/MS/MS being under 20.
I am honestly doing the best I have been on TRT with my LC/MS/MS in the single digits, I think 6 was my last test, and SHBG was 12. Free Estradiol 0.18, lab range is <0.45, I'm doing Cyp @ 16mg/D which has been placing my Free T at the lab range.

I also have to use Exemestane/Aromasin @ 12.5mg EOD. I had been using Anastrozole @ .25mg EOD which just wasn't quite enough so I worked with my Dr to try a different approach and its been this that has done better for me with E.

Somehow I missed your response. I still have a ton of anastrozole so I’ll continue to use it until I run out. Then, I will try aromasin since it appears you’re able to control your estrogen much better.

I want to get my estrogen into single digits. I’m currently taking .25 eod and have an E2 of 19. Do you think if I alternate taking .25mg and .5 mg EOD I’ll be able to achieve this without bottoming out too much?

 

[Pringle]

I went to daily about 5 weeks ago. Will get bloods done next week. 12mg ed. I am trying the change for two reasons, I want to drop AI and also evaluate if I am able to lower HCT and phlebotomy frequency. When on e3.5d I felt pretty good, but had to use .125 AI 2x week to keep E2 sides at bay. When my E2 gets below 20, I have same sides as when over 50. 30 seems to be the sweet spot for me.