Super lower ferratin & low E2 after introducing anastrozole

[chriskchris]

Hi everybody,

I thought I would share something a bit interesting for me as I got advanced labs finally.

Of note, my E2 which had been very high is now LOW after taking 0.40mg of anastrozole in the past week. From 300 to only 22 (81 pg/ml to 6 pg/ml). Meanwhile, my testosterone is excellent at 865 ng/DL.

Also interesting to note my ferratin is5.21 µg/L which is significantly below the low end of 23.9! I am a regular blood donor and usually go every three months since my doctor spooked me years' ago informing me I was on the higher end of normal for hematocrit. First time in 10-years we have tested ferratin. Have to say that I always felt tired. As a former full marathon runner I have never been the same since starting to donate blood as much. Maybe ferratin at play? Guessing it has been like this for years.

Lastly, my TSH is rather elevated at 4.11 miu/L, a hair below the high range; Free T3 is also close to being high.

My regiment for these results has been 110 mg of testosterone cypionate injected twice weekly at 300 miu of HCG (pregnyl) 3x per day plus for the first time in years I re-introduced anastrozole at 0.40 mg broken between two doses. What a drug!

Penis sensitivity and energy levels improved from rock bottom dysfunction last month with high E2 and no anastrozole. The anastrozole made a massive difference but I think I went too far. The ferratin might explain why I always feel sub par. Something new for me to look into.

Thought it would be of interest to share this in the group as as it sheds some light on how powerful anastrozole is, from a first-hand experience of someone who went from really high E2 to really low within one month off a very small dose.

I am 40-years old and had low testosterone since I was 16 (secondary, idiopathic...). Active in the gym, eat healthy, no smoke/drink or other known health conditions.

 

[Systemlord]

I am a regular blood donor and usually go every three months since my doctor spooked me years' ago informing me I was on the higher end of normal for hematocrit.

That’s not a reason to donate. Higher normal range hematocrit is one of the many benefits of TRT.

It’s even argued by experts that a slight elevation in hematocrit is healthier, blood pressure permitting, because the vascular system is more efficient at transporting oxygen at above range hematocrit.

This gives your blood higher oxygen carrying capacity. This is what you want.

Your doctor is clueless!

Of note, my E2 which had been very high is now LOW after taking 0.40mg of anastrozole in the past week.

You’re an AI over responder and I think any dose will drop your levels low. Best to lowered the test dose and lower E2 that way.

Adding daily Cialis can have an anti-estrogen effect thus changing T:E2 ratios.

 

[chriskchris]

That’s not a reason to donate. Higher normal range hematocrit is one of the many benefits of TRT.

It’s even argued by experts that a slight elevation in hematocrit is healthier, because the vascular system is more efficient at transporting oxygen at above range hematocrit.

This gives your blood higher oxygen carrying capacity. This is what you want.

Your doctor is clueless!


You’re an AI over responder and I think any dose will drop your levels low. Best to lowered the test dose and lower E2 that way.

Adding daily Cialis can have an anti-estrogen effect thus changing T:E2 ratios.

I actually take 5 mg of Cialis daily!

 

[Systemlord]

Lastly, my TSH is rather elevated at 4.11 miu/L, a hair below the high range; Free T3 is also close to being high.

In the beginning stages of thyroid disease, TSH is elevated and free thyroid hormones are normal. TSH can also become elevated as you get older.

Iodine supplements can raise the TSH rendering it useless for diagnostic purposes.

 

[chriskchris]

In the beginning stages of thyroid disease, TSH is elevated and free thyroid hormones are normal. TSH can also become elevated as you get older.

Iodine supplements can raise the TSH rendering it useless for diagnostic purposes.

Thanks for the information here, I really appreciate your feedback. My TSH has been above 4 since I started therapy about 10-years ago in my late 20s. Read online that there is controversy about it being 'subclinical' and whether it is treatable. Like testosterone I have read normal range does not mean normal. When I started t-therapy, they (general practioners and one urologist) told me I was normal with sub 200 ng/dl t-readings in my 20s despite chronic fatigue and severe erectile dysfunction. Fascinating really.

With my blood work here, I really just wanted to share how much impact anastrozole had on me. Not only by labs but also feeling. With high E2, I felt absolutely terrible. There are times T-therapy doesn't work for months even with E2 on the higher range of normal. Night-day difference since taking it only a week ago and in a very good way. Really hope I can get things in balance because it feels great.

Ultimately I would love to find the root cause of my problems that began as a teenager. With private blood testing and clinics, plus the knowledge of these forums there seems to be a much better chance.

 

[Systemlord]

When I started t-therapy, they (general practioners and one urologist) told me I was normal with sub 200 ng/dl t-readings in my 20s despite chronic fatigue and severe erectile dysfunction. Fascinating really.

They had no training, normal versus healthy aren't the same thing. These normal ranges have nothing to do with quality of life.

The problem I have with our medical system is doctors are trained in men's and women's diseases, they're not trained in men's and women's health.

Doctors don't get paid to keep you healthy, they get paid when things go wrong. You show up to your doctors appointment, high blood pressure is recorded. The next time of your doctor's visit your blood pressure is controlled, bamb, your doctor gets paid.

Read my signature below.

 

[Seagal]

Hi everybody,

I thought I would share something a bit interesting for me as I got advanced labs finally.

Of note, my E2 which had been very high is now LOW after taking 0.40mg of anastrozole in the past week. From 300 to only 22 (81 pg/ml to 6 pg/ml). Meanwhile, my testosterone is excellent at 865 ng/DL.

Also interesting to note my ferratin is5.21 µg/L which is significantly below the low end of 23.9! I am a regular blood donor and usually go every three months since my doctor spooked me years' ago informing me I was on the higher end of normal for hematocrit. First time in 10-years we have tested ferratin. Have to say that I always felt tired. As a former full marathon runner I have never been the same since starting to donate blood as much. Maybe ferratin at play? Guessing it has been like this for years.

Lastly, my TSH is rather elevated at 4.11 miu/L, a hair below the high range; Free T3 is also close to being high.

My regiment for these results has been 110 mg of testosterone cypionate injected twice weekly at 300 miu of HCG (pregnyl) 3x per day plus for the first time in years I re-introduced anastrozole at 0.40 mg broken between two doses. What a drug!

Penis sensitivity and energy levels improved from rock bottom dysfunction last month with high E2 and no anastrozole. The anastrozole made a massive difference but I think I went too far. The ferratin might explain why I always feel sub par. Something new for me to look into.

Thought it would be of interest to share this in the group as as it sheds some light on how powerful anastrozole is, from a first-hand experience of someone who went from really high E2 to really low within one month off a very small dose.

I am 40-years old and had low testosterone since I was 16 (secondary, idiopathic...). Active in the gym, eat healthy, no smoke/drink or other known health conditions.

You can adjust the AI dosing (imo you are a hyper responder) by e.g. dissolving it in alcohol

 

[Seagal]

That's what I would use.
E.g. one standard 1mg tablet per 10ml vodka
Every day 0.25ml would yield 0.175mg per week, about half of your current dose evenly distributed for stable blood values

 

[WhiteMale]

.40mg Anastrozole is a bit much. Was that one dose or cumulative in a week?

But, What's wrong with your E at ~22?

 

[chriskchris]

.40mg Anastrozole is a bit much. Was that one dose or cumulative in a week?

But, What's wrong with your E at ~22?

i took 0.25 mg and then took another .15 mg a couple days later with an hcg shot. it was the first time i ever had labs when anastrozole so quickly so had no idea what kind of an impact it would have. all i can say is that my penis sensitivity came back albeit not full throttle and i regained the ability to get an erection. muscular impact as well, as i started to get a big pump - something you notice as a gym goer. energy levels have also improved, something i notice as someone who jogs. high e2 means a super sluggish feel. it's awful! also it seems when high e2 is in play the hcg does not work, so you notice it in the scrotum size. low e2 allows for the scrotum to get bigger when using hcg unlike when e2 is higher.

this week i am going to try 0.25 mg after my next injection broken in two doses and re-test my bloodwork in a couple weeks.

 

[chriskchris]

one thing i suffer from is an extreme feeling of tiredness often. i struggle to read a newspaper without having to drowse off. i fall asleep at irregular times in the day even after normal sleep. used to attribute it to low testosterone but now i think it is low ferretin. rock bottom levels. totally dismayed that it was never checked until now after i selected the test as a bonus and paid out of pocket despite symptoms. even with t- therapy these symptoms have generally persisted.

will be interesting to see how i feel when ferratin is restored to adequate levels as i suspect it may have been chronically low for the past 5-years since i became a regular blood donor in 3-month intervals. always had normal hemoglobin but they do not test for ferratin at red cross canada. other things i believe low ferratin for are increased blood pressure and rapid heart beat. thought i might have cardiac issues. used to be able to run full marathons which seemed to change overnight as endurance faded.

my issues started way too young in life as a teenager so i am not sure until i see it whether the low ferratin is related to donating blood. will report back with updated labs for anybody interested. but i believe this low iron is a huge problem and has caused me to feel symptoms of extreme fatigue and low endurance, while the high side of normal e2 completely robs me of the ability to get an erection.....

 

[Seagal]

Do not disregard the other out of range lab values (monocytes). Maybe an underlying infection etc.