Starting on Anastrozole/dim

[Jackie Treehorn]

Dr. John Crisler knows EXACTLY what he's doing...he's one of the best at this game.

I agree. If Dr. Crisler is prescribing that amount, there is a good reason for it. We are not privy here to all of Shan's medical history, protocol history, lab results, etc...Dr Crisler is. He is quite literally, the last person I would question about this protocol.

 

[shan1784]

Well this was my second meeting with Dr. Crisler... My inital meet we went over labs that I had done very recently but was not through labcorp. To save $$$ they allowed these labs to get me started off.. Unfortunately it did not show the E test he wanted but did show E was elevated.. He wasn't comfortable addressing E at this time and instead broke my test cyp pins to 2 x week and started me on 100iu of HCG daily. I did complain of low libido and water retention in the inital meet so he said he wanted to see how my body reacted to the changes he made with my protocol. So round 2 he got to see how E responded in the test that he wanted so based on that he made the decision to start me on this dose of AI. I did get confirmation from Defy that .5mg is the correct dose he has ordered so I'm going to go with it...

I've suspected issues with E about 3 months after starting TRT 3 years ago with my primary care doc. Neither he or my Endo would consider looking into this possible issue... 3 years later it's being addressed by one of the top docs in the field... I'm going to gladly run with the protocol he's setup and not question it... If my E tanks then at least I'll pass the sweet spot and know what to look for and possibly see the other side.. I'm not to worried.. This has been a long time coming and I welcome the change...

Also here are my latest labs -


CBC With Differential/Platelet
WBC 5.5 x10E3/uL 3.4 - 10.8 01
RBC 5.23 x10E6/uL 4.14 - 5.80 01
Hemoglobin 16.5 g/dL 12.6 - 17.7 01
Hematocrit 48.7 % 37.5 - 51.0 01
MCV 93 fL 79 - 97 01
MCH 31.5 pg 26.6 - 33.0 01
MCHC 33.9 g/dL 31.5 - 35.7 01
RDW 14.0 % 12.3 - 15.4 01
Platelets 195 x10E3/uL 150 - 379 01
Neutrophils 53 % 01
Lymphs 35 % 01
Monocytes 9 % 01
Eos 2 % 01
Basos 1 % 01
Neutrophils (Absolute) 3.0 x10E3/uL 1.4 - 7.0 01
Lymphs (Absolute) 1.9 x10E3/uL 0.7 - 3.1 01
Monocytes(Absolute) 0.5 x10E3/uL 0.1 - 0.9 01
Eos (Absolute) 0.1 x10E3/uL 0.0 - 0.4 01
Baso (Absolute) 0.0 x10E3/uL 0.0 - 0.2 01
Immature Granulocytes 0 % 01
Immature Grans (Abs) 0.0 x10E3/uL 0.0 - 0.1 01
Comp. Metabolic Panel (14)
Glucose, Serum 72 mg/dL 65 - 99 01
BUN 19 mg/dL 6 - 24 01
Creatinine, Serum 1.22 mg/dL 0.76 - 1.27 01
eGFR If NonAfricn Am 74 mL/min/1.73 >59
eGFR If Africn Am 85 mL/min/1.73 >59
BUN/Creatinine Ratio 16 9 - 20
Sodium, Serum 138 mmol/L 134 - 144 01
Potassium, Serum 4.4 mmol/L 3.5 - 5.2 01
Chloride, Serum 98 mmol/L 97 - 108 01
Carbon Dioxide, Total 23 mmol/L 18 - 29 01
Calcium, Serum 9.2 mg/dL 8.7 - 10.2 01
Protein, Total, Serum 6.7 g/dL 6.0 - 8.5 01
Albumin, Serum 4.5 g/dL 3.5 - 5.5 01
Globulin, Total 2.2 g/dL 1.5 - 4.5
A/G Ratio 2.0 1.1 - 2.5
Bilirubin, Total 0.6 mg/dL 0.0 - 1.2 01
Alkaline Phosphatase, S 42 IU/L 39 - 117 01
AST (SGOT) 29 IU/L 0 - 40 01
ALT (SGPT) 35 IU/L 0 - 44 01

Testosterone,Free and Total
Testosterone, Serum 851 ng/dL 348 - 1197 01
Comment:
Adult male reference interval is based on a population of lean males
up to 40 years old.

Free Testosterone(Direct) 22.2 High pg/mL 6.8 - 21.5 02

DHEA-Sulfate 421.0 High ug/dL 102.6 - 416.3 01

TSH 1.040 uIU/mL 0.450 - 4.500 01

Prostate-Specific Ag, Serum
Prostate Specific Ag, Serum 0.7 ng/mL 0.0 - 4.0 01
Roche ECLIA methodology.
According to the American Urological Association, Serum PSA should
decrease and remain at undetectable levels after radical
prostatectomy. The AUA defines biochemical recurrence as an initial
PSA value 0.2 ng/mL or greater followed by a subsequent confirmatory
PSA value 0.2 ng/mL or greater.
Values obtained with different assay methods or kits cannot be used
interchangeably. Results cannot be interpreted as absolute evidence
of the presence or absence of malignant disease.

Estradiol, Sensitive 56.2 High pg/mL 8.0 - 35.0 02
This test was developed and its performance characteristics
determined by LabCorp. It has not been cleared by the Food and
Drug Administration.
Methodology: Liquid chromatography tandem mass spectrometry(LC/MS/MS)

Triiodothyronine,Free,Serum 2.9 pg/mL 2.0 - 4.4 01

 

[ERO]

How are you feeling on your new/updated protocol?

 

[shan1784]

How are you feeling on your new/updated protocol?

Thank you for asking... More energy for sure, libido has increased but can be way better still, better since of well being I guess I would say... I'm very happy thus far... The new protocol along with doing keto and losing bodyfat combined has really helped with overall physical and mental state...

 

[Gene Devine]

Shan - I've known Dr. Crisler for years and he's a very very good friend of mine.

He's my Doctor for TRT and while he let's me do what I want with my protocol because I know what I'm doing...there is NO ONE better at this then this man...and I mean that seriously.

.5 mg is a small dose and it will not crash you E2 while you are elevated with symptoms...what he prescribed is the right thing to do.

Back in the day the standard protocol used to be 1 mg of an AI for every 100 mg of injected Testosterone...can you believe that!!!

Things have changed of course...

If you feel anything negative please make sure to let Defy know right away...otherwise, follow his instructions and be well!

 

[HarryCat]

Don't overthink this. You are in the hands of one of the top experts in the field. It is normal to take a few months to dial in a protocol, but with his expertise you may get there quicker. Just be patient and do what he tells you to do.

 

[Jason Sypolt]

Dr. Crisler put me on Anastrozle/DIM 0.5mg/200mg twice a week in mid-June.

My initial Defy labs in early June showed E2 at 38 and that was with 0.25mg Anastrozole every 3 days and 60mg T-Cypionate every 3 days. The acne, bloating, and ED are finally improving and going away. Anastrozole is a powerful drug, but some of us convert T to E at an insane rate and are really sensitive to estrogens.

 

[Vitamin_C]

when I consulted with Defy and Dr. Crisler, I had sensitive E2 of 40 and a TT of 1074 on 120mg per week of Cyp in divided doses and I was doing HCG 250iu three times per week. Dr. Crisler first asked if I was experiencing any symptoms of elevated E2 and asked me some questions. I wasn't experiencing any overt symptoms at the time but I think I may have some minor bloating. I may consult with them again just to kick the tires on a micro dose+DIM compounded medication just to see how it makes me feel depending on what my next sensitive E2 looks like.

 

[shan1784]

So not to rekindle the fire here but thought I'd update on how this has or was going for me... First couple weeks I noticed after taking my AI dose with test injection as directed by Dr. Crisler was followed by very anxious jittery agitated state... Only happened the day of taking the AI dose. Gave it a few times before looking into it and found it common to take AI 24hrs after Test injection.. So I started doing that.. So my doses of AI were on Monday and Friday mornings as I take my test on Sunday and Thursday mornings.

First 2 doses were ok and thought here we go, it's looking good... Then a Saturday morning I woke up and felt like I was hit by a truck. Migrane, stiff sore neck, my skin was so hot cold sensitive, lethargic, etc... I honestly thought I had the flu... Even though I felt pretty bad, I took some Motrin and Excedrin, drank my coffee and headed to the gym... Felt better for the most part and didn't give it much thought.

Then the following Tuesday woke up the same way, managed to get to work and struggled all day, ended up going home half way through the day and missed the following day (wednesday) from work as well... Thursday I was fine, actually was improved for the most part on Wednesday but thought I must be sick so I gave it another day. Thursday and Friday came and went, then Saturday, boom, all happened again...

Finally when it happened again on Tuesday I thought it had to be the AI... I was experiencing mild to severe headaches, body aches all over, sensitive skin, lethargic, numbness in limbs at times, ear aches and even a little bit of sore throat... Sounds like I had the flu right, but it only happened the day after taking the AI then the following day was better for the most part...

I've decided to stop taking the AI and contact Defy which I haven't done as of yet.

Does this sound right, is the typical of E hitting rock bottom??? Any suggestions???

 

[Fireproof]

Wow - that is strange. I've crashed my E2 to zero before and never had those symptoms. Sounds more like an allergic reaction or some weird sensitivity.

Are you taking a compounded Anastrozole/DIM product? Or something else?

 

[shan1784]

Wow - that is strange. I've crashed my E2 to zero before and never had those symptoms. Sounds more like an allergic reaction or some weird sensitivity.

Are you taking a compounded Anastrozole/DIM product? Or something else?

To be honest not sure, just capsule I get from empower...

 

[CoastWatcher]

So not to rekindle the fire here but thought I'd update on how this has or was going for me... First couple weeks I noticed after taking my AI dose with test injection as directed by Dr. Crisler was followed by very anxious jittery agitated state... Only happened the day of taking the AI dose. Gave it a few times before looking into it and found it common to take AI 24hrs after Test injection.. So I started doing that.. So my doses of AI were on Monday and Friday mornings as I take my test on Sunday and Thursday mornings.

First 2 doses were ok and thought here we go, it's looking good... Then a Saturday morning I woke up and felt like I was hit by a truck. Migrane, stiff sore neck, my skin was so hot cold sensitive, lethargic, etc... I honestly thought I had the flu... Even though I felt pretty bad, I took some Motrin and Excedrin, drank my coffee and headed to the gym... Felt better for the most part and didn't give it much thought.

Then the following Tuesday woke up the same way, managed to get to work and struggled all day, ended up going home half way through the day and missed the following day (wednesday) from work as well... Thursday I was fine, actually was improved for the most part on Wednesday but thought I must be sick so I gave it another day. Thursday and Friday came and went, then Saturday, boom, all happened again...

Finally when it happened again on Tuesday I thought it had to be the AI... I was experiencing mild to severe headaches, body aches all over, sensitive skin, lethargic, numbness in limbs at times, ear aches and even a little bit of sore throat... Sounds like I had the flu right, but it only happened the day after taking the AI then the following day was better for the most part...

I've decided to stop taking the AI and contact Defy which I haven't done as of yet.

Does this sound right, is the typical of E hitting rock bottom??? Any suggestions???

Easy way to find out - have a sensitive estradiol test pulled at Discountedlabs.com. It's inexpensive and will answer the question with certainty.

 

[RLB112]

My previous trt doc prescribed me a .5 anastrozole dose and that was with a non sensitive est.of 19 and yes that's one reason why I left them and switched to defy . It did some weird things to my eyes like they were twitching and had tunnel vision. I woke up the next day feeling totally shot. Had to drag my ass out of bed it was rough..I cut my dose in half after research here and haven't had that issue again.I have blood work coming up in a couple weeks to see how things are

 

[Noah Yates]

.25 EOD of anastrozole/arimidex

 

[Mike Lauer]

Shan1784: I'm having the same issues. (With Defy also) On the 2nd week of .25mg/200Mg Anastrozole and DIM combo and about 8 hours after taking 4th pill with .80mg shot of test-cyp developed chronic neck/trap pain, sore knees, fatigue and chills. I'm going to pay to have my E2 sensitive test taken care of and see where my E2 is at. Sides are pretty standard with what I am seeing with low e2/ adex use.

 

[RLB112]

I recently went to .5/200 dim 2xw. E2 sensitive came back at 58 on .25/200 dim so I increased dose to .5..e2 came back yesterday at 32. I haven't had any of the effects I had when I first started the .5 dose. Just make sure you take with food. I take everything in pill form after meals