Spermatogenesis induction

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madman

Super Moderator
This is gold really enjoyed this one!

Worthy of a sticky!









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Defy Medical TRT clinic doctor
Key point being stressed here!


HYPERGONADOTROPIC HYPOGONADISM

* Just to close this issue concerning hypergonadotropic hypogonadism the only thing that you can do in an case of azoospermia is a testicular sperm extraction through a multiple biopsy and although there are already some medical intervention in the literature that you can do before TESE none of them has proved its efficacy so actually there is very few things you can do in terms of hyperhyp




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* although there are already some medical intervention in the literature that you can do before TESE none of them has proved its efficacy so actually there is very few things you can do in terms of hyperhyp


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Love this very thorough here!


* and of course Sertoli cell not only nurses spermatogenesis but produce anti-müllerian hormone (AMH) and Inhibin B so consider this as markers of a healthy Sertoli cell

* It's usually the immature Sertoli cell that produces anti-müllerian hormone and the mature Sertoli cell that produces Inhibin B and of course Inhibin as its known denotes has a negative effect on the production of FSH not LH and this is the whole physiology that we must know in order to understand where we discuss now which is spermatogenesis





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Dr.Goulis lays out the treatment options nicely!




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Pulsatile GnRH

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hCG monotherapy

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Combined gonadotropin therapy

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Sequential gonadotropin therapy

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Key point here!

* Accordingly, one should not generalize our findings and propose that hCG/FSH therapy would benefit all infertile male patients.




post #5 (Go nuts!)





* in general it takes 68-72 days to make a new sperm, so 2-3 months

* the sperm are very delicate you have to take care of them, the testosterone generating cells (leydig) in the testicles are fairly resilient, the sperm generating cells (sertoli/germ) are fairly delicate
 
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