Should I be concerned?

[Hank Moody]

This morning I discovered what appears to be some sort of sediment or contamination in a recently opened 5ml vial of compounded 200mg/ml testosterone cypionate in grapeseed oil. This vial has never been exposed to heat or direct sunlight and has always been stored in a dark, cool place. While filling the syringe for my daily injection, I thought I noticed air bubbles but upon further inspection it looks like some type of sediment. Not sure how this could be pulled out of the vial and into the syringe but regardless it has me concerned. I have been on TRT for 5.5 years and have never encountered anything like this and am not sure what to do. I will not be using this vial any longer but not sure if I should inform my doctor and/or the pharmacy that I received the medication from. Thoughts or suggestions from the knowledgeable members here are appreciated.

 

[MarcoFL]

What pharmacy is it from?

 

[Vince]

This morning I discovered what appears to be some sort of sediment or contamination in a recently opened 5ml vial of compounded 200mg/ml testosterone cypionate in grapeseed oil. This vial has never been exposed to heat or direct sunlight and has always been stored in a dark, cool place. While filling the syringe for my daily injection, I thought I noticed air bubbles but upon further inspection it looks like some type of sediment. Not sure how this could be pulled out of the vial and into the syringe but regardless it has me concerned. I have been on TRT for 5.5 years and have never encountered anything like this and am not sure what to do. I will not be using this vial any longer but not sure if I should inform my doctor and/or the pharmacy that I received the medication from. Thoughts or suggestions from the knowledgeable members here are appreciated.

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That vial looks terrible, take it back to the pharmacy. If it came mail order, call them now.

 

[Hank Moody]

What pharmacy is it from?

Empower

 

[MarcoFL]

I would call them.

 

[HealthMan]

Looks like crystallized testosterone. Was it exposed to cold temps?

 

[bumpy]

Looks like it crashed. Warm the vial up in very hot water (don’t boil it) and see if it dissolves the crystals.

Regardless, Test from a legit lab or compounder should not be crashing.

By the way if you inject it you will be in some very severe pain until those crystals dissolve in the muscle.

 

[ivkonst2017]

Looks like the test crystalized back, return that thing to the pharmacy. Bad preparation. I've kept testosterone in a fridge for months(dont do that) and nothing like that happened, but after I understood how wrong was that I threw it in the trash.

 

[madman]

This morning I discovered what appears to be some sort of sediment or contamination in a recently opened 5ml vial of compounded 200mg/ml testosterone cypionate in grapeseed oil. This vial has never been exposed to heat or direct sunlight and has always been stored in a dark, cool place. While filling the syringe for my daily injection, I thought I noticed air bubbles but upon further inspection it looks like some type of sediment. Not sure how this could be pulled out of the vial and into the syringe but regardless it has me concerned. I have been on TRT for 5.5 years and have never encountered anything like this and am not sure what to do. I will not be using this vial any longer but not sure if I should inform my doctor and/or the pharmacy that I received the medication from. Thoughts or suggestions from the knowledgeable members here are appreciated.

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The only way T would have crystallized is if it was stored at low temperatures.

Although far from common it can happen with big pharma let alone compounded T.

It will almost look like tiny pieces of fiberglass throughout the oily solution.

As others have stated warming the vial would redissolve any crystals that have formed

It can still be used.




post#15

How long after the "best use date" (BUD) does T cyp/prop retain its full efficacy?

Let's say it is unopened, in a closed box not near sunlight, at room temperature. Is there a certain point it tends to get "weaker"? One year after the BUD? Two years after? Right away? Same question regarding AIs. Any data in regards to AIs as well?

www.excelmale.com

Depo®-Testosterone (testosterone cypionate injection, USP) CIII

Pfizer Kalamazoo site has investigated the product complaints on Depo®- Testosterone regarding crystallization of contents in 100 and 200 mg/mL vials. The investigation has found that although crystals have been observed, the formulation of crystals does not impact patient safety, efficacy, or product quality when the US Product Insert (USPI) instructions are followed prior to administration.

Depo-Testosterone 100 mg/mL is very highly concentrated and 200 mg/mL is a supersaturated sterile solution for injection, comprised of cottonseed oil, testosterone cypionate, and benzyl alcohol. The HIGH CONCENTRATIONS of active ingredients make the product very susceptible to CRYSTALLIZATION when EXPOSED TO TEMPERATURES LOWER THAN THE RANGES RECOMMENDED ON THE LABEL [20°C to 25°C (68°F to 77°F)].




The USPI states:

“Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit. Warming and shaking the vial should redissolve any crystals that may have formed during storage at temperatures lower than recommended.

 

[Hank Moody]

Looks like crystallized testosterone. Was it exposed to cold temps?

No it was not exposed to cold at all and I used about a quarter of the 5ml vial before I noticed the crystals. I will be sending it back to Empower today - I do not feel comfortable using it. I cracked open another vial today from the exact same lot and I will certainly be watching it closely to see if something similar happens.