Senolytic Drug Advancements For Health Extension

[Vtail]

I bet Rapamycin will have the same effect as Metformin:

Metformin Decreases Aerobic Capacity, Muscle Mass and Testosterone

I have been on 2x1000mg a day but I lost my endurance(Kun Khmer/Muay Thai training) and workout capacity/volume. I had no common sides from it, no diarrea etc, but felt physically limited. A strange feeling of being limited by the amount of energy the body had stored or could generate on the...

www.excelmale.com

In my experience that is not the case. Metformin definitely has a negative impact on my aerobic capacity, but not so with Rapamycin. If anything it makes me feel a bit more energetic. I was prescribed 6mg/week.

 

[Fernando Almaguer]

Cold sores are dose dependent, back your dose off a bit.

Im not taking it. Are you? experience?

 

[BadassBlues]

I bet Rapamycin will have the same effect as Metformin:

Metformin Decreases Aerobic Capacity, Muscle Mass and Testosterone

I have been on 2x1000mg a day but I lost my endurance(Kun Khmer/Muay Thai training) and workout capacity/volume. I had no common sides from it, no diarrea etc, but felt physically limited. A strange feeling of being limited by the amount of energy the body had stored or could generate on the...

www.excelmale.com

It's the dosage and dosage schedule. This is not a drug you want to have active in your system for long periods of time. The trick is to dial in a dose that will result in a temporary shutdown of mTOR-1, and not mTOR-2 so to trigger autophagy without the side effects caused by shutting down mTOR-2. The half life (depending on dose and schedule) is around 62 hours:

Sirolimus: Uses, Interactions, Mechanism of Action | DrugBank Online

Sirolimus is an mTOR inhibitor immunosuppressant used to prevent organ transplant rejections, treat lymphangioleiomyomatosis, and treat adults with perivascular epithelioid cell tumors.

go.drugbank.com

Half-life
The mean ± SD terminal elimination half-life (t½) of sirolimus after multiple dosing in stable renal transplant patients was estimated to be about 62 ± 16 hours.

This is why the biweekly dosing schedule is the most common choice.

mTOR is by no means the enemy, it is responsible for protein synthesis. Body builders, athletes and fitness enthusiasts all count on that function to be at the highest level possible, we take supplements and alter our diet to achieve that. The problem is that all of that activity creates waste products in our cells which cause a host of problems, including AGING. This is where autophagy plays it's critical role in cleaning out all of that garbage.

The discussion of dosage and schedules would depend on many factors. A body builder on a growth cycle would want to wait until that cycle was over and then do a cleanup on aisle 5. You wouldn't want to have your mTOR compromised while preparing for an athletic or strenuous event. It's the down cycle, the recovery period where this would be utilized.

Those looking purely for aging benefits would do well with a biweekly dose.

So, long winded...sorry. The drug should only be in your system for brief periods of time to allow autophagy to happen. Unlike Metformin which is a daily drug that is active for long, if not indefinite periods of time.