Role of Estradiol (Estrogen) in Men and Its Management

[Nelson Vergel]

Testosterone Needs to Be Converted into Estradiol to Prevent Fat Accumulation

How Targeting Fat Cells’ Estrogen Receptors Could Fight Obesity Tracy Hampton, PhD In adipocytes, fat cells, a particular estrogen-receptor appears critical for energy supplying mitochondria to function properly. The discovery points to a potential drug target for boosting fat tissue...

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[Nelson Vergel]

DHT and estradiol regulate fat in different areas of the body

Testosterone metabolites differentially regulate obesogenesis and fat distribution Zachary L. Sebo, Matthew S. Rodeheffer Abstract Objective: Low testosterone in men (hypogonadism) is associated with obesity and type II diabetes. Testosterone replacement therapy has been shown to reverse...

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[Nelson Vergel]

Estrogens and Brain Health

The Role of Estrogen Receptors and Their Signaling across Psychiatric Disorders Abstract: Increasing evidence suggests estrogen and estrogen signaling pathway disturbances across psychiatric disorders. Estrogens are not only crucial in sexual maturation and reproduction but are also highly...

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[Nelson Vergel]

The association between serum estradiol levels and sperm DNA integrity - PubMed

In men from the general population, BMI has been associated with a lower sperm DNA fragmentation index (DFI). We wondered whether this could be due to estradiol, which is associated with BMI and reported important for sperm function. Our objective was to investigate the association between...

pubmed.ncbi.nlm.nih.gov

 

[Nelson Vergel]

Estradiol in Men on TRT: Surprising Results of a Groundbreaking Study

For more details on this study, click: https://www.excelmale.com/forum/threads/higher-estradiol-t-and-dht-correlated-to-higher-libido-in-older-hypogonadal-men-than-t-alone.24831/

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[Nelson Vergel]

I am always hot: Is this a high estradiol symptom?

Is being hot or even sweaty in bed at night. With my heat set at 61(!) degrees and one of three vents in my bedroom closed, I still need a ceiling fan on high speed and then in the latter half of the night it's totally opposite...body is cold. 22mg/D Cyp .25mg EOD (LC/MS/MS = 42) (Free Estrogen...

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[Nelson Vergel]

Estrogen-It's what makes a real man

https://www.nbcnews.com/nightly-news/video/study-low-estrogen-can-cause-problems-for-men-47991875700 Study: Low estrogen can cause problems for men (2013) Dr. Joel Finkelstein, an endocrinologist at Harvard Medical School and the lead author of a new study, talks about the effects of declining...

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[Nelson Vergel]

The article "Estradiol as a Male Hormone" gives an overview of the role of estradiol (E2) in men's health, with a focus on its effects on reproductive function, growth hormone, insulin-like growth factor-1 (GH-IGF-1) axis regulation, bone growth and maintenance of skeletal health, body composition and glucose metabolism, vasomotor stability, and brain function.

An enzyme called aromatase converts testosterone and androstenedione into E2 in men. Evidence shows that E2 is an important hormone in men because it controls the hypothalamic-pituitary-testicular axis, reproductive function, the GH-IGF-1 axis, bone growth and keeping the skeleton healthy, body composition and glucose metabolism, and vasomotor stability.

One of E2's main jobs in the male reproductive system is to control the process of making sperm. The enzyme aromatase creates E2 in the Sertoli cells of the testis. There, it works as a paracrine factor to help germ cells mature and divide. E2 also affects the way the hypothalamic-pituitary-gonadal axis works, which controls how much testosterone is made and how sperm are made.

It has also been shown that E2 affects how the GH-IGF-1 axis works in men. In healthy guys, the level of E2 is linked to the level of IGF-1 in the blood. Also, E2 may control how much GH is made by stopping it from being made.

E2 is a hormone that is important for men's bones to grow and stay healthy. It works in a roundabout way by encouraging the differentiation and activity of osteoblasts, which are the cells that build bone, and by stopping the differentiation and activity of osteoclasts, which break down bone.

E2 also has an impact on men's body types and how they use glucose. In particular, E2 seems to encourage body fat to build up in the peripheral (i.e., subcutaneous) areas while stopping it from building up in the central (i.e., abdominal) areas. Also, E2 has been shown to improve the way hypogonadal guys use glucose.

Men's vasomotor steadiness is also kept in check by E2. Nitric oxide (NO) production is believed to be the cause of E2's effects on blood vessels. E2 may also help control blood pressure by blocking the renin-angiotensin-aldosterone system (RAAS), which is a key regulator of blood volume and blood pressure.

Lastly, E2 has been shown to affect how men's brains work. During growth, the brain needs E2 in order to become more masculine. Less is known about what E2 does to the brain when a person is an adult. But it has been suggested that E2 may have something to do with how guys think and feel, as well as how their brains work.
Overall, E2 is an important hormone for regulating male reproductive function, the GH-IGF-1 axis, bone growth and maintaining skeletal health, body makeup and glucose metabolism, vasomotor stability, and brain function. Even though more research is needed to fully understand how E2 affects men's health, the evidence so far shows that E2 is a key player in these processes and has important clinical implications for the diagnosis and treatment of male health conditions.

 

[Nelson Vergel]

The Benefits of Estrogen in BodyBuilding

Once again, an excellent article from Anabolic.org Glucose Utilization and Estrogen Estrogen may play a very important role in the promotion of an anabolic state by affecting glucose utilization in muscle tissue. This occurs via an altering of the level of available glucose 6-phosphate...

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[Nelson Vergel]

Female sex hormone helps insulin cross blood vessel lining into muscles, lowering glucose

https://www.utsouthwestern.edu/newsroom/articles/year-2023/oct-estrogen-anti-diabetic-effects.html DALLAS – Oct. 23, 2023 – The quintessential female sex hormone estrogen stimulates cells that line blood vessels to deliver insulin to muscles, lowering blood sugar and protecting against Type 2...

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