Rethinking Testosterone: Oral Testosterone Modern Hormone Therapy

madman · Jan 23, 2025

Join Dr. Jared Pelo and Shalin Shah for an in-depth discussion about revolutionizing testosterone therapy. Shah, with his extensive background in healthcare investment and drug development, shares insights about Kyzatrex, an innovative oral testosterone medication, and discusses why testosterone has been misunderstood in medicine.

Learn about:

* Why testosterone was historically vilified and how recent research is changing perspectives

* The groundbreaking Traverse Study and its implications for cardiovascular health

* How daily oral testosterone better mimics the body's natural rhythm compared to injections

* The critical role of testosterone in metabolic health, diabetes prevention, and longevity

* Why testosterone testing should be standard in preventive care

* The future of hormone therapy for both men and women

Key Timestamps:

00:18 - Shalin's journey into testosterone research and development of Kyzatrex
03:18 - Understanding oral testosterone and debunking liver toxicity myths
06:03 - Historical misconceptions: Why testosterone was unfairly vilified
11:04 - The Traverse Study (2023): Proving cardiovascular safety
13:28 - T4DM Study: Testosterone's impact on diabetes prevention
15:22 - Why daily oral testosterone better mimics natural body rhythms
24:05 - The Testosterone Project's three initiatives:

Making testosterone testing standard
Creating FDA-approved options for women
De-scheduling testosterone

36:09 - Why Kyzatrex chose a cash-pay model for better access

madman · Jan 23, 2025

How daily oral testosterone better mimics the body's natural rhythm compared to injections

15:22 - Why daily oral testosterone better mimics natural body rhythms

03:18 - Understanding oral testosterone and debunking liver toxicity myths

madman · Jan 23, 2025

Thread 'Understanding Testosterone and Muscle Preservation'

Nov 23, 2024

Never heard about oral TU LOL!

In this episode of The Dr. Gabrielle Lyon Show, Dr. Lyon sits down with Shalin Shah, CEO of Marius Pharmaceuticals, to explore the science, benefits, and future of testosterone therapy. Shalin has been a driving force behind bringing Kyzatrex, an FDA-approved oral testosterone, to market—making testosterone therapy more accessible and effective for both men and women. From breaking down misconceptions to advocating for better access to hormone therapy, this conversation sheds light on how testosterone plays a crucial...

madman · Jan 23, 2025

Thread 'Oral Testosterone Therapy in Hypogonadal Men: A Comprehensive Systematic Review'

Nov 17, 2024

Introduction

Background and significance

Hypogonadism, characterized by low testosterone levels, is a significant clinical condition affecting a substantial proportion of the male population, particularly older men. The management of hypogonadism often involves testosterone replacement therapy (TRT), which can be administered through various routes, including intramuscular injections, transdermal patches, and oral formulations. While injectable and transdermal options have been extensively studied, oral testosterone therapy, particularly using testosterone undecanoate (TU)...

madman · Jan 23, 2025

Thread 'Testosterone Therapy Today: Clinical Advances & Safety with Dr. Abraham Morgentaler'

Sep 16, 2024

Dr. Morgentaler back in action!

Listen closely, loved this one!

Pros/Cons oral TU (51:24-57:12)

*one of the things that the orals have transformed is the concept that you have to have a continually high level of testosterone to get the benefits and clearly that's not true and the safety profile seems to be improved by having levels that fluctuate some during the day returning to close to or even baseline

Synopsis

Dr. Morgentaler starts by sharing his pioneering journey with...

Pros/Cons oral TU (51:24-57:12)

*one of the things that the orals have transformed is the concept that you have to have a continually high level of testosterone to get the benefits and clearly that's not true and the safety profile seems to be improved by having levels that fluctuate some during the day returning to close to or even baseline

madman · Jan 26, 2025

Thread 'Kyzatrex - A New Oral T Option: Kyzatrex's pharmacokinetics and delivery system for effective use'

Jan 26, 2025

Hayden Collier, PharmD is the director of clinical services at nuBioAge. He is committed to advancing healthcare through innovative, patient-centered approaches. With a passion for weightlifting, he draws parallels between the discipline of fitness and the importance of prevention in modern medicine. Hayden’s expertise extends beyond the pharmacy, blending sports science with cutting-edge medical strategies to redefine how we approach health and longevity. A dedicated husband, father, and sportsman, he brings the same focus and energy to both personal and...

madman · Feb 6, 2025

Thread 'Breaking New Ground in Men's Health: Oral Testosterone (Kyzatrex)'

Feb 6, 2025

In this episode, host McCall McPherson discusses a breakthrough in testosterone therapy with Shalin Shah, CEO of Marius Pharmaceuticals. They explore the development and benefits of Kyzatrex, a new oral testosterone replacement therapy. Shalin shares his journey into the testosterone space and highlights the importance of testosterone for overall health. They address the prevalence of low testosterone, its symptoms, and the limitations of traditional therapies. Kyzatrex offers a safer, more effective alternative with stable hormone levels and fewer...