Restoring Nitric Oxide to the Body

[madman]

 

[Fernando Almaguer]

Would taking a daily or eod tadalafil or viagra be an effective NO stimulator for preventative measures?

 

[Guided_by_Voices]

Would taking a daily or eod tadalafil or viagra be an effective NO stimulator for preventative measures?

There is another thread on long-term cialis, but note that this class of drugs blocks the enzyme that breaks down nitric oxide, but they don't directly produce it, so if someone is not making enough in the first place, these drugs won't work well.

 

[Iron Gator]

I have really bought into the science of this. Starting in Feb 2024, I take:
1. 10mg/day Tadalafil
2. NO supplement referenced above (slowing down on this because of the below supplements)
3. L-Citrulline
4. Arginine (multiple versions in one product by vitacost)
5. Fermented beet powder

I was worried about taking NO producers with Tadalafil but I found some studies that showed a benefit to the combination of both. I have no zero issues with BP and generally feel better taking this than not. Hopefully working some magic internally.

 

[Fernando Almaguer]

I have really bought into the science of this. Starting in Feb 2024, I take:
1. 10mg/day Tadalafil
2. NO supplement referenced above (slowing down on this because of the below supplements)
3. L-Citrulline
4. Arginine (multiple versions in one product by vitacost)
5. Fermented beet powder

I was worried about taking NO producers with Tadalafil but I found some studies that showed a benefit to the combination of both. I have no zero issues with BP and generally feel better taking this than not. Hopefully working some magic internally.

Any worries about down regulation of receptors without cycling off tadalafil? I heard its good to cycle. but hey if not cool. Also where do you get your citrulline and beet powder please?

 

[Iron Gator]

Any worries about down regulation of receptors without cycling off tadalafil? I heard its good to cycle. but hey if not cool. Also where do you get your citrulline and beet powder please?

I was unaware of down regulation of receptors. I'll research that and if necessary cycle it. Thanks for bring that up!

all items from Amazon.

My beet powder: Parker Naturals Fermented Organic Beets Powder. 9.52oz.
Citrulline with Malate: Nutricost L-Citrulline Malate 2:1 (600 Grams) (Blue Raspberry)
Citrulline:Nutricost Pure L-Citrulline (Base) Powder (600 Grams)

 

[Fernando Almaguer]

I was unaware of down regulation of receptors. I'll research that and if necessary cycle it. Thanks for bring that up!

all items from Amazon.

My beet powder: Parker Naturals Fermented Organic Beets Powder. 9.52oz.
Citrulline with Malate: Nutricost L-Citrulline Malate 2:1 (600 Grams) (Blue Raspberry)
Citrulline:Nutricost Pure L-Citrulline (Base) Powder (600 Grams)

looks good! Thank you!

 

[madman]

Any worries about down regulation of receptors without cycling off tadalafil? I heard its good to cycle. but hey if not cool. Also where do you get your citrulline and beet powder please?

*No evidence has emerged concerning the development of any form of dependence or tolerance with the chronic use of PDE5 inhibitors.

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[t_spacemonkey]

when someone tries to produce a pharma drug - red flag. also there is data that too much NO is harmful

a)
High levels of nitric oxide (NO) in the body can lead to the formation of peroxynitrite (ONOO-). Peroxynitrite is a potent oxidant and nitrating agent formed by the reaction of nitric oxide with superoxide (O2−). This compound can cause significant damage to cells and tissues, contributing to various pathological conditions. Here are some potential effects and health implications of elevated NO and peroxynitrite:

1. **Oxidative Stress**: Peroxynitrite can cause oxidative damage to lipids, proteins, and DNA, leading to cell dysfunction and death.

2. **Inflammation**: High levels of peroxynitrite can exacerbate inflammation by activating inflammatory pathways and damaging cells involved in the immune response.

3. **Endothelial Dysfunction**: Peroxynitrite can impair the function of endothelial cells, which line blood vessels, leading to vascular diseases such as atherosclerosis and hypertension.

4. **Neurodegeneration**: In the nervous system, peroxynitrite can damage neurons and glial cells, potentially contributing to neurodegenerative diseases like Parkinson's disease and Alzheimer's disease.

5. **Mitochondrial Damage**: Peroxynitrite can disrupt mitochondrial function, leading to impaired energy production and increased production of reactive oxygen species (ROS).

6. **DNA Damage and Mutagenesis**: Peroxynitrite can cause nitration and oxidation of DNA bases, which can lead to mutations and contribute to cancer development.

Managing nitric oxide levels and oxidative stress through lifestyle changes, diet, and potentially antioxidant supplementation may help mitigate the harmful effects of peroxynitrite. It's essential to maintain a balance of NO for its beneficial roles in vascular health and immune response while minimizing the risk of oxidative damage.

b)

 

[Nelson Vergel]

Our late Gene Devine's and ExcelMale's most visited post:

Gene's Nitric Oxide Stack

Many have used this stack for massive hard pumps in the gym, significant vascularity and excellent erectile function not discounting the health benefits. If you're looking for any of these benefits and more...give it a try! Nitric Oxide Stack Bed Time 5 mg of Tadalafil (Cialis) 3000 mg of...

www.excelmale.com

 

[Nelson Vergel]

and @Vince version:

I simplified my Nitric Oxide stack!

L-Citrulline DL-Malate 2-1, 1 heaping teaspoon Beta Alanine, 1/2 heaping teaspoon L-Norvaline, 1/2 heaping teaspoon I take twice a day My nitric oxide stack just go too big last year, I completely stopped taking it for 3 months and even stopped all ED meds for over a week. My workout were...

www.excelmale.com

 

[Seagal]

View attachment 46247

Is there more information for why this NO decline occurs in men? Correlation to T? What effect has TRT on NO production.

 

[Fernando Almaguer]

when someone tries to produce a pharma drug - red flag. also there is data that too much NO is harmful

a)
High levels of nitric oxide (NO) in the body can lead to the formation of peroxynitrite (ONOO-). Peroxynitrite is a potent oxidant and nitrating agent formed by the reaction of nitric oxide with superoxide (O2−). This compound can cause significant damage to cells and tissues, contributing to various pathological conditions. Here are some potential effects and health implications of elevated NO and peroxynitrite:

1. **Oxidative Stress**: Peroxynitrite can cause oxidative damage to lipids, proteins, and DNA, leading to cell dysfunction and death.

2. **Inflammation**: High levels of peroxynitrite can exacerbate inflammation by activating inflammatory pathways and damaging cells involved in the immune response.

3. **Endothelial Dysfunction**: Peroxynitrite can impair the function of endothelial cells, which line blood vessels, leading to vascular diseases such as atherosclerosis and hypertension.

4. **Neurodegeneration**: In the nervous system, peroxynitrite can damage neurons and glial cells, potentially contributing to neurodegenerative diseases like Parkinson's disease and Alzheimer's disease.

5. **Mitochondrial Damage**: Peroxynitrite can disrupt mitochondrial function, leading to impaired energy production and increased production of reactive oxygen species (ROS).

6. **DNA Damage and Mutagenesis**: Peroxynitrite can cause nitration and oxidation of DNA bases, which can lead to mutations and contribute to cancer development.

Managing nitric oxide levels and oxidative stress through lifestyle changes, diet, and potentially antioxidant supplementation may help mitigate the harmful effects of peroxynitrite. It's essential to maintain a balance of NO for its beneficial roles in vascular health and immune response while minimizing the risk of oxidative damage.

b)
View attachment 46381

Our late Gene Devine's and ExcelMale's most visited post:

Gene's Nitric Oxide Stack

Many have used this stack for massive hard pumps in the gym, significant vascularity and excellent erectile function not discounting the health benefits. If you're looking for any of these benefits and more...give it a try! Nitric Oxide Stack Bed Time 5 mg of Tadalafil (Cialis) 3000 mg of...

www.excelmale.com

Does anyone know how old Gene was, its sad maybe this stack didn't work. He was in shape and took this cardio protective protocol seriously. Rest in peace