Renal Protection of Metformin

[madman]

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Join host Chase Hendrickson, MD, from Vanderbilt University Medical Center, in a discussion about a recent article in The Journal of Clinical Endocrinology & Metabolism providing data in support of metformin being renal protective. He talks with Steven D. Wittlin, MD, from the University of Rochester Medical Center and guest expert Silvio Inzucchi, MD, medical director of the Yale Medicine Diabetes Center. The article featured this month, by Wang et al, was first published online in JCEM in July 2024: “Renal Protective Effect of Metformin in Type 2 Diabetes Patients.”

 

[Fernando Almaguer]

SUMMARY PLEASE MET GOOD FOR KID?

 

[Vince]

Metformin: the updated protective property in kidney disease - PMC

Metformin is a frontline hypoglycemic agent, which is mainly prescribed to manage type 2 diabetes mellitus with obesity. Emerging evidence suggests that metformin also exerts protective effects against various kidney diseases. Some postulate that ...

pmc.ncbi.nlm.nih.gov

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Table 1. Metformin management in patients with T2DM with stage 3A, 3B, and 4 CKD.​

CKD stage​	eGFR (mL·min-1·1.73 m-2)​	Recommended daily dose​
3A​	45-59​	0.5 g in the morning + 1 g in the evening​
3B​	30-44​	0.5 g in the morning + 0.5 g in the evening​
4​	15-29​	500 mg in the morning​