PT - 141 (Bremelanotide) for Improved Sex Drive (Libido) and Erections

• Bremelanotide (PT 141) is a synthetic melanocortin compound
• It is a ‘melanocortin receptor agonist’- activates melanocortin receptors in the body
• ‘Melanocortins’ refer to a group of peptide hormones derived in the pituitary gland
• Several melanocortins have been identified, each producing different effects
• Researchers have investigated multiple synthetic melanocortin compounds for different uses including:
– Aphrodisiac drug; tanning agent; anti-obesity
– Studied for effects on mood and cognition
-Used to treat sexual dysfunction or used to improve sexual performance in healthy patients
• Produces multiple effects that influence sexual response including a noticeable increase in desire, increased libido, increase in physical response, vaginal vasocongestion (women), and erection (men)

SIDE EFFECTS:

• Nausea
• Hypertension
• Flushing
• Priapism (men)
• Injection site reactions
• Headache
• <4% reported in Vyleesi trials

PHARMACEUTICAL PRODUCT APPROVED IN THE US FOR WOMEN:

• Commercially available as Vyleesi™
– Specific indication
– One time use injection pen with two dose options
– >$2000 retail price for four (4) doses
– Not covered by insurance for off-label uses
– Only commercial product in the US that contains bremelanotide

OFF-LABEL USES:

• Hypoactive sexual desire disorder (HSDD) in premenopausal women
• Sexual dysfunction in men
• Erectile dysfunction
• Premature ejaculation
• Low libido; underactive sex drive
• Lack of desire
• Low response to sexual stimulation; anorgasmia

COMBINATION THERAPY:


• Some doctors prescribe a combination of two or more treatments to effectively treat the complex issues that result in sexual dysfunction
• Bremelanotide + Sildenafil has been shown to enhance erectile response in some patients
• Men with low testosterone + sexual dysfunction are often given TRT

COMPLEMENTARY PRODUCTS USED WITH PT 141

• Sildenafil (capsules, ODTs, troches)
• Tadalafil (capsules, ODT, troches)
• Vardenafil (capsules, ODT, troches)
• Bimix, Trimix, or Quadmix (+ Supers)
• Testosterone (cream, injectable, pellets, nasal gel)
• Arousal Cream
• Oxytocin (nasal spray or troches)
• Premature ejaculation (PE) medications

Erection peptide: Pt-141

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PT 141

Good morning, I recently received PT 141 from a compounding pharmacy with a script from my provider. I'm a little confused about dosing even after speaking to my provider about this. I received a 2 milliliter vial which states 10,000mcg/10mg per milliliter. The instructions state inject 2-5...

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The Amazing Bremelanotide PT-141 (Vyleesi)

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Why so little info on Bremelanotide (PT-141-Vyleesi)?

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PT-141 and Trimix?

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Libido Peptide for Men and Women: PT 141 (Brand: Vyleesi for Premenopausal women)

If one were to use pt 141 and it was successful does that imply anything? In other words, the mechanism that made it work can that be made to do the same thing with any other supplement or drug that doesnt have the pt 141 side effects? Im tired, not sure im typing this right. Is there another...

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Has anyone used PT-141 to improve erections?

I am curious re: the peptide PT-141. It sounds like it is useful for those suffering from ED and sex drive/sexual satisfaction issues. Does anyone here have experience with this? Is it safe to use? What kind of dosage?? Regards, Gemini99

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I get results from PT-141, but I never know what or, more difficult to manage, when.

Took the shot yesterday at 4pm. At T+2½ hours I had a raging boner that lasted about an hour. The timing wasn't good so it more or less went away until it was time for sex at T+5 hours. Then with some stimulation the erection came back quite strong. The erection started strong through intercourse and sensitivity was enough to allow a pretty easy orgasm.

Then at T+9 hours, the almost painful erection came back. It was strong enough and long-lasting enough that I began to worry about priapism. I have had success using an ice pack to relieve the strain but I'm in a hotel so I resorted to dipping my dick in a glass of ice water. That worked but I had to repeat about ½ hour later. (FYI, I also keep with me a shot of phenylephrine if cold therapy doesn't work, but I have yet to need that, or heaven forbid, go to the ER.) Later, I told my wife that I came close to waking her up for a medically necessary blowjob - she was not amused, but I wasn't kidding.

I can see the PT-141 working for me but I really need to figure out the timing. If like to hear how others using PT-141 are handling the timing. The wife is "one-and-done" so taking advantage of multiple opportunities is not a possibility, even if I could climax with such a short refractory period.

I would start by dropping your dose slightly. There are numerous reports that sleep tends to "activate" the affect so keep that in mind as well.

 

I get results from PT-141, but I never know what or, more difficult to manage, when.

Took the shot yesterday at 4pm. At T+2½ hours I had a raging boner that lasted about an hour. The timing wasn't good so it more or less went away until it was time for sex at T+5 hours. Then with some stimulation the erection came back quite strong. The erection started strong through intercourse and sensitivity was enough to allow a pretty easy orgasm.

Then at T+9 hours, the almost painful erection came back. It was strong enough and long-lasting enough that I began to worry about priapism. I have had success using an ice pack to relieve the strain but I'm in a hotel so I resorted to dipping my dick in a glass of ice water. That worked but I had to repeat about ½ hour later. (FYI, I also keep with me a shot of phenylephrine if cold therapy doesn't work, but I have yet to need that, or heaven forbid, go to the ER.) Later, I told my wife that I came close to waking her up for a medically necessary blowjob - she was not amused, but I wasn't kidding.

I can see the PT-141 working for me but I really need to figure out the timing. If like to hear how others using PT-141 are handling the timing. The wife is "one-and-done" so taking advantage of multiple opportunities is not a possibility, even if I could climax with such a short refractory period.

From similar accounts of unpredictability of PT-141, it does lead to trepidation. Your wife sounds like mine...when we had a sex life. Perhaps the issue isn't the drug's window of efficacy but more of having a spouse or partner who's up to spontaneous sexual activity. Sex 'should' be enjoyable, not like planning a long, exhausting trip, LOL!

 

I have tried PT141 with slight side effects. Just a little queasy feeling but not bad or bothersome. However I only got a small boost in libido using 1-2 mg subq. Don't think it is worth the money for me.

 

I have tried PT141 with slight side effects. Just a little queasy feeling but not bad or bothersome. However I only got a small boost in libido using 1-2 mg subq. Don't think it is worth the money for me.

Likewise, I get a mild discomfort but nothing that is a deterrent from taking it so my experiments go on. As long as there is no significant downside, I can keep trying different variations and try to get a handle on the timing.

 

PT 141 not being made by Empower!

I have used branded Vyleesi, but the side effects at the auto injector dose was just to much for me to tolerate. I started using half doses, (about 9 units). Not as good a response, but still helpful. Now my doc tells me Empower has quite making Bremalanotide (PT141). Does anyone know a good...

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I Recently purchased pt-141 but scared of pripism. What are tthings to try before ER

 

I don’t think you will have an issue. It does yield more and better erections, however, they don’t seem to last hours on end, that would put you at risk. The erections come and may last 20-30 minutes but generally not 4 hours, which is when things can get dangerous. If the erections come and go for you are getting fresh blood into the penis, so low risk.