PT-141 and Trimix?

[DaveK2204]

What would be the general recommended dose for PT-141 if I wanted to start ?

From Chat GPT...

The typical starting dose for men using PT-141 (Bremelanotide) is 1 mg administered subcutaneously (via injection) about 45 minutes to an hour before desired effects. Some users may start lower, around 0.5 mg, to assess tolerance before increasing the dose.

Dosage Guidelines:​

• Low dose: 0.5 mg
• Typical starting dose: 1 mg
• Effective range: 1-2 mg
• Max recommended dose: 2 mg (higher doses don’t necessarily increase effectiveness and may increase side effects)
• Frequency: No more than 1 dose every 24-36 hours, with a max of 2 doses per week

Onset & Duration:​

• Onset: 30-60 minutes
• Peak effects: 2-4 hours
• Duration: Up to 12-24 hours (varies by individual)

Possible Side Effects:​

• Nausea (most common)
• Flushing
• Increased blood pressure
• Headaches

Would you like recommendations on how to minimize side effects or any other details?

 

[bruin]

From Chat GPT...

The typical starting dose for men using PT-141 (Bremelanotide) is 1 mg administered subcutaneously (via injection) about 45 minutes to an hour before desired effects. Some users may start lower, around 0.5 mg, to assess tolerance before increasing the dose.

Dosage Guidelines:​

• Low dose: 0.5 mg
• Typical starting dose: 1 mg
• Effective range: 1-2 mg
• Max recommended dose: 2 mg (higher doses don’t necessarily increase effectiveness and may increase side effects)
• Frequency: No more than 1 dose every 24-36 hours, with a max of 2 doses per week

Onset & Duration:​

• Onset: 30-60 minutes
• Peak effects: 2-4 hours
• Duration: Up to 12-24 hours (varies by individual)

Possible Side Effects:​

• Nausea (most common)
• Flushing
• Increased blood pressure
• Headaches

Would you like recommendations on how to minimize side effects or any other details?

much appreciated, Thanks

 

[DaveK2204]

much appreciated, Thanks

It's been a while but for me the 2mg was spot on. I had no sides so it was easy to titrate up. It's a fun "med" to add into the mix...my only complaint was sleep being disrupted with a raging hard on lol

 

[Guided_by_Voices]

What would be the general recommended dose for PT-141 if I wanted to start ?

What I have found effective and what I believe Dr. Hertoghe suggests is 100-300mcg (micrograms, or 1/10 to 1/3 of a milligram ) to start with. You can always increase but higher doses seem to create exactly the problem that was reported earlier in this thread...too much in the short run followed by what seems like desensitization. This would be doubly true of a combination with bi/trimix. I have found the dosage above used twice a week to give a subtle but very noticeable boost. @Cataceous has a thread discussion using lower doses more frequently. Many have reported that sleep seems to "activate" the effect.

 

[Guided_by_Voices]

From Chat GPT...

The typical starting dose for men using PT-141 (Bremelanotide) is 1 mg administered subcutaneously (via injection) about 45 minutes to an hour before desired effects. Some users may start lower, around 0.5 mg, to assess tolerance before increasing the dose.

Dosage Guidelines:​

• Low dose: 0.5 mg
• Typical starting dose: 1 mg
• Effective range: 1-2 mg
• Max recommended dose: 2 mg (higher doses don’t necessarily increase effectiveness and may increase side effects)
• Frequency: No more than 1 dose every 24-36 hours, with a max of 2 doses per week

Onset & Duration:​

• Onset: 30-60 minutes
• Peak effects: 2-4 hours
• Duration: Up to 12-24 hours (varies by individual)

Possible Side Effects:​

• Nausea (most common)
• Flushing
• Increased blood pressure
• Headaches

Would you like recommendations on how to minimize side effects or any other details?

IME either of these dosages is way too high to start with, ESPECIALLY for someone also using Trimix where the result could be dangerous. As with anything else it may work for some people and higher doses may be required for "hard cases", however there is no reason to start this high and the bad experiences from people who do are one of the reasons IMO that PT-141 has not seen broader adoption. AFAIK the only formal clinical trials have been for women, so I would guess that the source for the above is from PED forums which are notoriously over-populated with the more-is-better crowd.

 

[DaveK2204]

IME either of these dosages is way too high to start with, ESPECIALLY for someone also using Trimix where the result could be dangerous. As with anything else it may work for some people and higher doses may be required for "hard cases", however there is no reason to start this high and the bad experiences from people who do are one of the reasons IMO that PT-141 has not seen broader adoption. AFAIK the only formal clinical trials have been for women, so I would guess that the source for the above is from PED forums which are notoriously over-populated with the more-is-better crowd.

I agree with what you wrote. I took "Bruin's" question for starting dose for just on PT-141 since there was no mention of Trimix. As we know...Chat GPT is just a tool but should not replace one's own due diligence.

I also agree with the sleep "activation" thing...that was my experience too. Downside was trying to sleep with a raging hard on

 

[VacationMan]

As has been pointed out in other threads and in my experience, you took a dose of PT-141 that is far too high to start with, so I don't think it's valid to discourage people from trying a reasonable dose (e.g. 100-300mcg) if it's something they might benefit from.

When prescribed PT-141, the dose was prescribed at 1.0 to 2.5 units on an insulin syringe. 1cc of PT-141 equates to 10mg of the peptide, so do the arithmetic. This dose was spot on correct.

ChatGPT? Seriously?

I stand firm on - try one or the other, but not both simultaneously.

 

[VacationMan]

It's been a while but for me the 2mg was spot on. I had no sides so it was easy to titrate up. It's a fun "med" to add into the mix...my only complaint was sleep being disrupted with a raging hard on lol

Same experience here. It was fun alright, but the sleep disruption caused by the random spontaneous erections eventually became annoying! The wife was like "Again? OMG, get away from me you SOB!" LOL

 

[Guided_by_Voices]

When prescribed PT-141, the dose was prescribed at 1.0 to 2.5 units on an insulin syringe. 1cc of PT-141 equates to 10mg of the peptide, so do the arithmetic. This dose was spot on correct.

ChatGPT? Seriously?

I stand firm on - try one or the other, but not both simultaneously.

There is no magic that makes the prescribed dose a correct dose, especially since correct will change based on circumstances. That is what the wisdom of crowds and the forums like this are for. For example, if the prescribed dose is based on "hard cases" and you are not one of those, then it will be high. There are plenty of prescribed doses that are IME way too high, metformin being another example.

 

[bruin]

I agree with what you wrote. I took "Bruin's" question for starting dose for just on PT-141 since there was no mention of Trimix. As we know...Chat GPT is just a tool but should not replace one's own due diligence.

I also agree with the sleep "activation" thing...that was my experience too. Downside was trying to sleep with a raging hard on

I appreciate this experiential advice, great! My original question was specifically concerning PT 141 solely with out anything else, Tri M, Cialis, etc