I'd be curious to know what side effects happen when you take PT-141. For instance, is it a vasodiolator? Does it raise or lower BP? Any other short term side effects?
PT-141 and Trimix?
- Thread starter Swolldaddypump
- Start date
I'd be curious to know what side effects happen when you take PT-141. For instance, is it a vasodiolator? Does it raise or lower BP? Any other short term side effects?
DorianGray
Active Member
Short term rise in BP in women apparently:
What to Know About Vyleesi, the New Libido-Boosting Drug for Women
It’s already being dubbed the new “female Viagra.”
www.prevention.com
As far as side effects in men, I can tell you, I experience mild coughing episodes, slightly runny nose, makes me yawn more and feel like stretching (the kind of reflex stretching you do when, trying to relax). Nothing that would make me not use it. I haven't experienced any headaches or indication of BP elevation. No flushing or hot flashes.
Will see. The PT-141 I tried from a peptide company gave me the flushing and nausea and not much else. never tested my BP, but I guess I will when this comes in. Even though PT-141 isn't supposed to act on skin color like Melantonan...it def gave me a slight tan. Some people even asked if I went on vacation. Thats good and bad...I like the color, but don't want to look like someone that goes to a tanning booth.
DorianGray
Active Member
So, @wondering did you try the pharmacy grade PT-141? Different effects than peptide company version?
FedEx says it is shipping tonight. Will try later this week.
Tried 1mg last night. Flushing, mild nausea, but absolutely nothing sexual. Will try 1.5mg next week and if nothing onto 2mg. I'm skeptical again. Hope it isn't $205 down the drain.
DorianGray
Active Member
I noticed a significant difference between 1.0 and 1.75. What is the concentration of the drug? The one I have is 10,000mcg/ml
Same. Prescribed by Dr. Saya.
madman
Super Moderator
Excretion
Terminal half-life Approximately 2.7 hours (range 1.9-4.0 hours)
Clearance 6.5 ± 1.0 L/h
madman
Super Moderator
Absorption
Bioavailability 100% after subcutaneous injection
Time to peak Approximately 1 hour (range 0.5- 1 hour) in plasma
madman
Super Moderator
Bremelanotide
Dosing/administration (for women with HSSD)
1.75 mg injected subcutaneously into the abdomen or thigh; use as needed at least 45 minutes prior to anticipated sexual activity; do not use more than 1 dose in 24 hours or 8 doses per month.
madman
Super Moderator
Short term rise in BP in women apparently:
What to Know About Vyleesi, the New Libido-Boosting Drug for Women
It’s already being dubbed the new “female Viagra.”
As far as side effects in men, I can tell you, I experience mild coughing episodes, slightly runny nose, makes me yawn more and feel like stretching (the kind of reflex stretching you do when, trying to relax). Nothing that would make me not use it. I haven't experienced any headaches or indication of BP elevation. No flushing or hot flashes.
Common adverse reactions
Nausea (8%), flushing (1%), injection site reaction (1%), headache (2%)
Warnings and precautions
• Transient increase in blood pressure and reductions in heart rate
• Focal hyperpigmentation
• Nausea
Contraindications
Uncontrolled hypertension or known cardiovascular disease
Drug interactions
Naltrexone, Indomethacin
• Slows gastric emptying so may affect time-dependent drugs
Use in specific populations
Pregnancy
• Avoid in pregnancy; use contraception if child-bearing potential; discontinue use if pregnancy suspected Lactation
• Use with caution; no data available Pediatric/geriatric
• Safety/efficacy not studied Renal impairment
• Caution in severe renal impairment (eGFR <30 mL/min/1.73 m2 ) Hepatic impairment
• Caution in severe hepatic impairment
madman
Super Moderator
Bremelanotide is a melanocortin receptor agonist.7 It nonselectively activates MC1R, MC2R, MC3R, MC4R, and MC5R receptor subtypes. Neurons expressing MC4R are present in the central nervous system and peripheral tissues. Activation of these receptors modulates brain pathways involved in sexual response.3,7
DorianGray
Active Member
Interestingly, 300 mg of yohimbe bark gives me a similar but less intense sexual urge and mental effect but also side effects of runny nose but nothing for penile stimulation itself. Unlike, PT-141 where I get involuntary wood and a lot of tumescence.
I have some friends who like yohimbe but it drives me up the wall in any dosage which is kinda odd because I have a very high tolerance for stimulants. I have resorted to mixing my own pre-workout supplements in part because seems everything included yohimbe.
I tried 6 injections about a year ago. Resulted in a major increase in libido; however, the most it did as far as erection quality was concerned was to generate a major chubby. I injected it about 5 o'clock in the morning. About one hour later I felt a weird sensation or feeling of apprehensation overcome my body. By 7 0'clock, my penis started to become a bit engorged and I started to get really horny. The weird sensation began to ebb and I had a strong desire to wake my wife and initiate sex. At about the three hour mark, I had about a 60 to 70% erection and a strong desire to engage in intercourse. Unfortunately, my erection was not quite hard enough for penetration. Very frustrating.
I subsequently resorted to constriction to achieve a 90% erection and although I was able to engage in intercourse, I was never able to orgasm. The failure may partially have been a result of the constriction, but I felt it was the effects of the PT141. The partial engorgemet lasted for at least six more hours. A few months later, I started using Trimix which was significantly more successful and satisfying.
Since Trimix concentrates on the blood flow in the penis and PT141 works on the mind, it would be interesting to see how the combination of the two would work together. Now that I think about it, I would like to experiment with it. Just need to build up my courage to do it. If I do, I will definitely "publish" the results.
I subsequently resorted to constriction to achieve a 90% erection and although I was able to engage in intercourse, I was never able to orgasm. The failure may partially have been a result of the constriction, but I felt it was the effects of the PT141. The partial engorgemet lasted for at least six more hours. A few months later, I started using Trimix which was significantly more successful and satisfying.
Since Trimix concentrates on the blood flow in the penis and PT141 works on the mind, it would be interesting to see how the combination of the two would work together. Now that I think about it, I would like to experiment with it. Just need to build up my courage to do it. If I do, I will definitely "publish" the results.
that is discouraged due to concerns of priapism.
VacationMan
Active Member
Titrate up my no more than 2 units (Trimix) each time until you get a good result. Wait at least 2 days between injections too. For me, 5 to 8 units of Trimix does the trick every time. For others, it may take more (or less). Everyone is different.
What I can tell you? Do NOT mix both Trimix and PT-141 -or- a PDE5 inhibitor together. You're begging for a trip to the ER to deal with priapism if you do that! #Embarrassing
What I can tell you? Do NOT mix both Trimix and PT-141 -or- a PDE5 inhibitor together. You're begging for a trip to the ER to deal with priapism if you do that! #Embarrassing
Will do 6units perhaps Friday night. Would never combine PT141 and Cialis. Even though neither of those have helped me.
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