Pre-treatment serum testosterone level can be a useful factor to predict the improvement in bladder outlet obstruction by tadalafil for male patients

[madman]

Pre-treatment serum testosterone level can be a useful factor to predict the improvement in bladder outlet obstruction by tadalafil for male patients with lower urinary tract symptoms induced by benign prostatic obstruction





ABSTRACT

Introduction: To investigate possible pre-treatment factors related to the therapeutic effect of tadalafil on bladder outlet obstruction (BOO).

Materials and methods: Eighty untreated outpatients with lower urinary tract symptoms (LUTS) due to BOO received 5mg tadalafil daily for 12 months. Subjective symptoms and objective findings were evaluated before and 12 months after treatment. At 12 months, the patients were divided into two groups according to an improvement grade in BOO index (BOOI). Patient characteristics including age, serum total testosterone level (TT), PSA, and prostate volume, and subjective and objective parameters on LUTS were set as candidates of pre-treatment factors, and the parameters that influenced the improvement of BOO were statistically analysed.

Results: A total of 69 patients with mean age of 69.8years and mean prostate volume of 48.8mL were included. Subjective symptoms and BOOI were significantly ameliorated after 12 months. In terms of an improvement of BOOI, 30 patients (43.5%) showed insignificant improvement in BOO, whereas 39 patients (56.5%) exhibited excellent improvement. Comparison of pre-treatment factors between the groups showed that TT was the only independent predictor related to the improvement in BOO. The improvement of BOO was significantly better in patients with higher TT.

Conclusions: Pre-treatment TT was considered to be a useful predictor of therapeutic effects of tadalafil for BOO.






Conclusions

Tadalafil was effective in the improvement of BOO for patients with LUTS due to BPO. Especially, a higher ameliorating effect on improving BOO was observed in patients with higher serum TT level (cut-off value of
5.0ng/mL). Pre-treatment serum TT level was considered to be a useful predictor of therapeutic effects of tadalafil on BOO.

 

[Lilyway]

I didn't know that much about it. In general, I am now in a difficult period, and I try to search as many forums and sites as possible for information. I want to understand what happened to my husband. In short, he was diagnosed with a severe eye problem. The doctor explained that this was due to the bladder treatment he later received, namely the substance Elmiron. At first, I was so shocked and uninformed that I didn't understand anything. Arriving home, I decided to search for information and I found out that it is illegal to produce and sell treatments that include Elmiron. I was shocked to discovered from Drugwatcher about all this and decided to contact them for help.