madman
Super Moderator
Abstract
Tadalafil is a selective phosphodiesterase type 5 (PDE5) inhibitor commonly used for the treatment of erectile dysfunction and benign prostatic hyperplasia. Its mechanism of action involves the inhibition of PDE5, leading to increased levels of nitric oxide and cyclic guanosine monophosphate in the corpus cavernosum, which facilitates smooth muscle relaxation. This article reviews studies using tadalafil in the treatment of cardiovascular diseases and emphasizes its potential advantages in conditions such as pulmonary arterial hypertension, atherosclerosis,coronary artery disease, myocardial infarction, heart failure, stroke, diabetic ulcers, and cardiomyopathy. Although tadalafil shows potential efficacy in treating cardiovascular disease,further experimental studies are needed to clarify its pharmacological effects on cardiovascular protection beyond PDE5 inhibition.
2. The effects of tadalafil in cardiovascular disease
2.1. Pulmonary arterial hypertension (PAH)
2.2. Atherosclerosis and CAD
2.3. Heart failure and myocardial infarction
2.4. Stroke
2.5. Diabetic vascular disease
2.6. Cardiomyopathy
3. Potential mechanisms of tadalafil in different cardiovascular diseases
In conclusion, in this review, in addition to treating ED and BPH, it was highlighted how tadalafil may exhibit significant potential to improve cardiovascular diseases (Table 1).In PAH, tadalafil has been shown to reduce pulmonary arterial pressure, improve exercise capacity, and reduce clinical deterioration. In atherosclerosis and CAD, tadalafil may help attenuate the progression of atherosclerosis and CAD. In heart failure and myocardial
Tadalafil is a selective phosphodiesterase type 5 (PDE5) inhibitor commonly used for the treatment of erectile dysfunction and benign prostatic hyperplasia. Its mechanism of action involves the inhibition of PDE5, leading to increased levels of nitric oxide and cyclic guanosine monophosphate in the corpus cavernosum, which facilitates smooth muscle relaxation. This article reviews studies using tadalafil in the treatment of cardiovascular diseases and emphasizes its potential advantages in conditions such as pulmonary arterial hypertension, atherosclerosis,coronary artery disease, myocardial infarction, heart failure, stroke, diabetic ulcers, and cardiomyopathy. Although tadalafil shows potential efficacy in treating cardiovascular disease,further experimental studies are needed to clarify its pharmacological effects on cardiovascular protection beyond PDE5 inhibition.
2. The effects of tadalafil in cardiovascular disease
2.1. Pulmonary arterial hypertension (PAH)
2.2. Atherosclerosis and CAD
2.3. Heart failure and myocardial infarction
2.4. Stroke
2.5. Diabetic vascular disease
2.6. Cardiomyopathy
3. Potential mechanisms of tadalafil in different cardiovascular diseases
In conclusion, in this review, in addition to treating ED and BPH, it was highlighted how tadalafil may exhibit significant potential to improve cardiovascular diseases (Table 1).In PAH, tadalafil has been shown to reduce pulmonary arterial pressure, improve exercise capacity, and reduce clinical deterioration. In atherosclerosis and CAD, tadalafil may help attenuate the progression of atherosclerosis and CAD. In heart failure and myocardial
