Peyronie's disease (bent penis) and testosterone deficiency: Is there a link?

[Nelson Vergel]

Source: World J Urol | Posted 1 week ago
Peyronie's disease and testosterone deficiency: Is there a link?; Aditya I, Grober E, Krakowsky Y; World Journal of Urology (Mar 2019)
Tags: Erectile Dysfunction

INTRODUCTION Peyronie's disease (PD) and testosterone deficiency (TD) impact men at the same stage of life and can ultimately contribute to erectile dysfunction. There is speculation that low levels of testosterone (T) may predispose men to penile fibrosis; however, there is no published, up-to-date review summarizing the current evidence. Therefore, we conducted a narrative review of the literature exploring the relationship between PD and TD.

METHODS A comprehensive systematic search of existing literature of five online databases from June 1990 to June 2018 examining the relationship between PD and TD was conducted. The Cochrane risk-of-bias tool for randomized trials and the risk-of-bias assessment tool for cohort studies were used to evaluate the quality of studies.

RESULTS Six studies were identified (n = 675). Overall, five studies supported the link between PD and TD by demonstrating relationships in PD patients with low total T, free T, bioavailable T, greater penile curvature, and plaque development. However, one study demonstrated no connection between the conditions. The literature is restricted by small studies with methodological flaws.

CONCLUSION There are a number of mechanisms to support the link between TD and PD. The literature on the topic is limited by small studies which are overall conflicting. The findings of this work suggest the need for larger, prospective studies to clarify the role of TD in the development, evaluation, and treatment of PD. Establishing such a relationship could change management of PD as a diagnosis of PD may encourage clinicians to evaluate a patient's testosterone levels.

 

[S1W]

There was definitely a link for me - in fact, PD was my main reason for going on TRT. After having my world shattered after speaking to several docs who told me there basically was no cure and that in extreme cases surgery is a high-risk option and injections can have had mixed results, I read every scholarly article on PD that I could find. Several noted the link between PD and low T, so that set me on the path to TRT.

TRT + low dose daily Cialis not only helped prevent worsening, but actually reversed my PD. Pain all but gone, curvature significantly reduced, plaques noticeably smaller or gone.

My case of PD was not one of the extreme ones you see that make you cringe, but still, it was alarming to say the least. TRT was a godsend.

 

[Nelson Vergel]

Treatment for Peyronie's Disease to improve ED

Peyronie’s disease: new paradigm for the treatment of a unique cause of erectile dysfunction Culley Carson ABSTRACT Peyronie’s Disease is an incurable condition of the tunica albuginea of the penis associated with scarring, plaque formation, and penile deformity on erection. It is often...

www.excelmale.com

 

[Gianluca]

There was definitely a link for me - in fact, PD was my main reason for going on TRT. After having my world shattered after speaking to several docs who told me there basically was no cure and that in extreme cases surgery is a high-risk option and injections can have had mixed results, I read every scholarly article on PD that I could find. Several noted the link between PD and low T, so that set me on the path to TRT.

TRT + low dose daily Cialis not only helped prevent worsening, but actually reversed my PD. Pain all but gone, curvature significantly reduced, plaques noticeably smaller or gone.

My case of PD was not one of the extreme ones you see that make you cringe, but still, it was alarming to say the least. TRT was a godsend.

that is amazing, if I could ask a couple of questions, do you know approx at what degree was your erect penis before TRT+ Cialis? how old are you and what is your Free Test level now? what was your daily Cialis dose? thanks

 

[S1W]

that is amazing, if I could ask a couple of questions, do you know approx at what degree was your erect penis before TRT+ Cialis? how old are you and what is your Free Test level now? what was your daily Cialis dose? thanks

Sure - feel free to ask as many questions as you like.

I do not know the angle, though as I mentioned it was not extreme. It was more of a curve like a banana, and not even as pronounced as that. However, it was definitely noticeable. The pain was significant too.

I was late 30s when this happened. I'm fairly certain I injured myself having sex with my wife with a very poor erection. Now early 40s.

My FT level now is not indicative of where it has been since I began TRT...just got a strange set of labs lol and I'm likely due for a protocol adjustment. To answer your question though, it was usually in the upper 20s using Labcorp (range 6.8-21.5). TruT calculation around the same range. Using TruT numbers, I have noticed that both libido and erectile function decrease once my FT numbers get below low 20s. And I've never had FT higher than low 30s. Mid 20s to low 30s seems optimal for me...for now at least.

I think the addition of daily Cialis was a very key part of this healing process. TRT alone helped, but when I added daily Cialis is when I really started to notice a difference. I started out on 2.5mg day. Now using 5mg day. FWIW, I do notice that the effectiveness of Cialis seems to wane throughout the day and I have even considered asking my doctor if I could go to 5mg AM and PM. But still, Cialis + testosterone in my system seems to bring back NPT (night erections while sleeping) which I believe played a key role in healing.

Another key point - I'm a pretty confident guy and have a wonderful wife who I am very comfortable with. And still, this was very challenging mentally. I had to fight the tendency to just "force it" with less than ideal erections, which could cause further damage. And there were times my wife and I would get hot and heavy, and things just weren't working down there, and I'd have to just say, "Ya know, I don't think this is going to happen right now". Sounds silly but that was unbelievably hard to do. If I were just dating...this would have been way more challenging. The mental aspect, e.g. performance anxiety, that comes from this psychological trauma can make erections difficult too, even once some of the physiological issues are improved.

It's rare that that happens anymore. And I no longer have any pain with erections. That said, they'll probably never be what they were in my 20s. Additionally, my wife and I always have lube available in the bedroom (I believe this makes it far less likely to injure the penis during sex, for those prone to such injuries).

 

[Gianluca]

Sure - feel free to ask as many questions as you like.

I do not know the angle, though as I mentioned it was not extreme. It was more of a curve like a banana, and not even as pronounced as that. However, it was definitely noticeable. The pain was significant too.

I was late 30s when this happened. I'm fairly certain I injured myself having sex with my wife with a very poor erection. Now early 40s.

My FT level now is not indicative of where it has been since I began TRT...just got a strange set of labs lol and I'm likely due for a protocol adjustment. To answer your question though, it was usually in the upper 20s using Labcorp (range 6.8-21.5). TruT calculation around the same range. Using TruT numbers, I have noticed that both libido and erectile function decrease once my FT numbers get below low 20s. And I've never had FT higher than low 30s. Mid 20s to low 30s seems optimal for me...for now at least.

I think the addition of daily Cialis was a very key part of this healing process. TRT alone helped, but when I added daily Cialis is when I really started to notice a difference. I started out on 2.5mg day. Now using 5mg day. FWIW, I do notice that the effectiveness of Cialis seems to wane throughout the day and I have even considered asking my doctor if I could go to 5mg AM and PM. But still, Cialis + testosterone in my system seems to bring back NPT (night erections while sleeping) which I believe played a key role in healing.

Another key point - I'm a pretty confident guy and have a wonderful wife who I am very comfortable with. And still, this was very challenging mentally. I had to fight the tendency to just "force it" with less than ideal erections, which could cause further damage. And there were times my wife and I would get hot and heavy, and things just weren't working down there, and I'd have to just say, "Ya know, I don't think this is going to happen right now". Sounds silly but that was unbelievably hard to do. If I were just dating...this would have been way more challenging. The mental aspect, e.g. performance anxiety, that comes from this psychological trauma can make erections difficult too, even once some of the physiological issues are improved.

It's rare that that happens anymore. And I no longer have any pain with erections. That said, they'll probably never be what they were in my 20s. Additionally, my wife and I always have lube available in the bedroom (I believe this makes it far less likely to injure the penis during sex, for those prone to such injuries).

thank you very much, I appreciate your advise and feedback. Based on data, Verapamil injections along with daily Cialis seems to work, I understand now that having a solid erection during sex is probably necessary not to occur in any penis damage. Did you know if you had scar tissue before?

 

[S1W]

thank you very much, I appreciate your advise and feedback. Based on data, Verapamil injections along with daily Cialis seems to work, I understand now that having a solid erection during sex is probably necessary not to occur in any penis damage. Did you know if you had scar tissue before?

I don't know whether or not I had scar tissue before.

 

[DragonBits]

Call me perverted, but the first thing I wondered, does a bent penis help you hit the g-spot?

 

[Gianluca]

Call me perverted, but the first thing I wondered, does a bent penis help you hit the g-spot?

considering the curvature up and the G spot being on the front of the Vagina, that's possible if you were on Top for example.