PDE5i Drugs and Tolerance

CoastWatcher · May 7, 2015

In the experience of the Forum, how likely is tolerance to develop with extended use of these drugs? Certainly there's buzz around the internet about that issue, but my pharmacist and doctor, though admitting they have seen it happen, claim that it's very rare. As a daily user of Cialis, with good results, it's something in the back of my mind. Many thanks.

HarryCat · May 7, 2015

I started daily cialis about 6 weeks ago. It was very effective for about the first week then the effectiveness started decline, it is now to the point where it doesn't seem to be doing much of anything any more. I'm thinking of giving it a break for a week or two and then trying again.

CoastWatcher · May 7, 2015

HarryCat said:
I started daily cialis about 6 weeks ago. It was very effective for about the first week then the effectiveness started decline, it is now to the point where it doesn't seem to be doing much of anything any more. I'm thinking of giving it a break for a week or two and then trying again.

Sorry to learn that Cialis isn't helping as it did when you started it. I've been using it for nearly a year as part of my overall TRT protocol. I have to say, I'm still pleased with my response to it, but think of "tolerance" every day when I take it.

Nelson Vergel · May 7, 2015

HarryCat

Some men do not respond to PDE5 inhibitors specially if they are nitric oxide deficient or have a lot of penile vascular issues (fibrosis,etc).

Have you tried Trimix?

Vince Carter · May 10, 2015

Ive been using Cialis 5mg 2x daily and like the results.

CoastWatcher · May 10, 2015

Vince Carter said:
Ive been using Cialis 5mg 2x daily and like the results.

How long have you been following that protocol, Vince?

Vince Carter · May 10, 2015

perhaps three weeks, I got the idea from Gene's nitric oxide stack recipe, it's a key ingredient.

CoastWatcher · May 10, 2015

Vince Carter said:
perhaps three weeks, I got the idea from Gene's nitric oxide stack recipe, it's a key ingredient.

I have been been taking 2.5mg every morning and 5.0mg every evening. So far, so good. As you note, Gene is quite explicit on the use of Cialis, presumably for an extended time. I just would hat to see it lose its effectiveness.