For some reason it seems to interfere with HCG rather drastically in my case. I couldn't figure out why all of the sudden I felt like I was crashing my levels after having just started *** oil for sleep and pain. Apparently there are studies that show that leydig cells have receptors for cannabinoids and they can suppress testosterone production. So for someone on TRT, probably not an issue, but for someone on HCG monotherapy, potentially a big issue.