New Idea: Four Compound TAMO intranasal ED & Libido Formulation

[Nelson Vergel]

I am trying to get a formulation combining these four compounds in an intranasal form.

Tadalafil:
Similar to sildenafil, tadalafil, another PDE5 inhibitor, has also been investigated for intranasal delivery. Studies have shown that intranasal tadalafil can rapidly reach systemic circulation, leading to a quicker onset of action compared to oral tadalafil. This route of administration may offer advantages for patients who desire more spontaneous sexual activity.

Apomorphine:
Apomorphine is a non-selective dopamine agonist that has shown potential as an intranasal therapy for ED. It acts by stimulating dopamine receptors in the brain, enhancing the release of nitric oxide, and promoting penile smooth muscle relaxation. Intranasal apomorphine has demonstrated promising results in improving erectile function, particularly in patients with neurogenic ED or those who do not respond well to PDE5 inhibitors.

Melanocortin receptor agonists:
Melanocortin receptor agonists, such as bremelanotide, have been investigated for their potential in treating ED. Intranasal bremelanotide acts on the central nervous system to promote sexual arousal and improve erectile function. Clinical trials have shown positive outcomes in terms of increased sexual desire and improved erectile function in patients with ED.

Oxytocin:
Oxytocin, a hormone involved in social bonding and sexual behavior, has been studied for its potential role in the treatment of ED. Intranasal oxytocin administration has shown promise in improving sexual function, desire, and satisfaction in both men and women. It may have a positive impact on psychogenic and functional ED.

 

[MDavidW76]

This sounds very interesting, recently I have been having a really hard time finishing with my wife, it’s totally not her, it’s me, and I have no idea why…

This last month we’ve been going at it like we did when we were teenagers and there’s no real ground rules from her, it’s pretty much “you can use my entire body to pleasure yourself”… turns out she has been neglecting to mention some really hot and dirty things she’s thought about and is totally into…

I’m fully on board, but I just cannot believe I cannot finish. It’s frustrating the both of us!

 

[Nelson Vergel]

Are you on any medications ? As we get older, orgasms are not as frequent or easy to achieve. Sometimes we need a dopamine fast.

 

[MDavidW76]

I’m on a few medications, but I will usually go through the literature to see what they will do, if anything, to prolactin, dopamine, histamine, other hormones, etc.

I find a lot of pushback from some of my doctors when it comes to me doing this, I work in research, and grew up around a lot of doctors, so I pretty much “talk shop” with them as I inform myself of what medications they will go to as their front line picks.

I ended up at the cardiologist, after all the testing they said they wished that their cholesterol levels was on par with mine, and that they wanted to give me Verapamil for my blood pressure, I reminded them that I had a micro-adenoma and that in some cases Verapamil may cause extreme prolactin elevation, I suggested one of the “sartans” and he put me on Losartan.

I’m doing bloodwork this week and we’re going to see what my prolactin level is at.

Hopefully my bloodwork gives us some clues.

 

[Nelson Vergel]

I’m on a few medications

Medications can affect orgasmic function.

 

[BadassBlues]

Are you on any medications ? As we get older, orgasms are not as frequent or easy to achieve. Sometimes we need a dopamine fast.

What he^ said...

 

[BadassBlues]

I am trying to get a formulation combining these four compounds in an intranasal form.

Tadalafil:
Similar to sildenafil, tadalafil, another PDE5 inhibitor, has also been investigated for intranasal delivery. Studies have shown that intranasal tadalafil can rapidly reach systemic circulation, leading to a quicker onset of action compared to oral tadalafil. This route of administration may offer advantages for patients who desire more spontaneous sexual activity.

Apomorphine:
Apomorphine is a non-selective dopamine agonist that has shown potential as an intranasal therapy for ED. It acts by stimulating dopamine receptors in the brain, enhancing the release of nitric oxide, and promoting penile smooth muscle relaxation. Intranasal apomorphine has demonstrated promising results in improving erectile function, particularly in patients with neurogenic ED or those who do not respond well to PDE5 inhibitors.

Melanocortin receptor agonists:
Melanocortin receptor agonists, such as bremelanotide, have been investigated for their potential in treating ED. Intranasal bremelanotide acts on the central nervous system to promote sexual arousal and improve erectile function. Clinical trials have shown positive outcomes in terms of increased sexual desire and improved erectile function in patients with ED.

Oxytocin:
Oxytocin, a hormone involved in social bonding and sexual behavior, has been studied for its potential role in the treatment of ED. Intranasal oxytocin administration has shown promise in improving sexual function, desire, and satisfaction in both men and women. It may have a positive impact on psychogenic and functional ED.

That sounds like a very well thought out multi faceted approach. A PDE5I for erection, Apomorphine for drive, Oxytocin for the bonding and anti anxiety, and the bremelanotide for added drive. Is PT-141 effective via nasal delivery?

 

[Keepfit1]

I am trying to get a formulation combining these four compounds in an intranasal form.

Tadalafil:
Similar to sildenafil, tadalafil, another PDE5 inhibitor, has also been investigated for intranasal delivery. Studies have shown that intranasal tadalafil can rapidly reach systemic circulation, leading to a quicker onset of action compared to oral tadalafil. This route of administration may offer advantages for patients who desire more spontaneous sexual activity.

Apomorphine:
Apomorphine is a non-selective dopamine agonist that has shown potential as an intranasal therapy for ED. It acts by stimulating dopamine receptors in the brain, enhancing the release of nitric oxide, and promoting penile smooth muscle relaxation. Intranasal apomorphine has demonstrated promising results in improving erectile function, particularly in patients with neurogenic ED or those who do not respond well to PDE5 inhibitors.

Melanocortin receptor agonists:
Melanocortin receptor agonists, such as bremelanotide, have been investigated for their potential in treating ED. Intranasal bremelanotide acts on the central nervous system to promote sexual arousal and improve erectile function. Clinical trials have shown positive outcomes in terms of increased sexual desire and improved erectile function in patients with ED.

Oxytocin:
Oxytocin, a hormone involved in social bonding and sexual behavior, has been studied for its potential role in the treatment of ED. Intranasal oxytocin administration has shown promise in improving sexual function, desire, and satisfaction in both men and women. It may have a positive impact on psychogenic and functional ED.

sound very interesting,look forward to hearing mroe, one thing in Hertoghes book on oxytocin is allegidly it lowers cortisol, he says to be sure to correct any cortisol deficiency before starting Oxytocin?, I bought some but havnt tried it yet.
Anyone tried Spedra/Avanafil allegedly works in about 55% of men whereas viagra is 80%?, allegedly it works in half the time of viagra. ie 15 misn instrad of 30 on emptyish stomach

 

[DorianGray]

I am trying to get a formulation combining these four compounds in an intranasal form.

Tadalafil:
Similar to sildenafil, tadalafil, another PDE5 inhibitor, has also been investigated for intranasal delivery. Studies have shown that intranasal tadalafil can rapidly reach systemic circulation, leading to a quicker onset of action compared to oral tadalafil. This route of administration may offer advantages for patients who desire more spontaneous sexual activity.

Apomorphine:
Apomorphine is a non-selective dopamine agonist that has shown potential as an intranasal therapy for ED. It acts by stimulating dopamine receptors in the brain, enhancing the release of nitric oxide, and promoting penile smooth muscle relaxation. Intranasal apomorphine has demonstrated promising results in improving erectile function, particularly in patients with neurogenic ED or those who do not respond well to PDE5 inhibitors.

Melanocortin receptor agonists:
Melanocortin receptor agonists, such as bremelanotide, have been investigated for their potential in treating ED. Intranasal bremelanotide acts on the central nervous system to promote sexual arousal and improve erectile function. Clinical trials have shown positive outcomes in terms of increased sexual desire and improved erectile function in patients with ED.

Oxytocin:
Oxytocin, a hormone involved in social bonding and sexual behavior, has been studied for its potential role in the treatment of ED. Intranasal oxytocin administration has shown promise in improving sexual function, desire, and satisfaction in both men and women. It may have a positive impact on psychogenic and functional ED.

TailorMade Compounding has the combination in a troche. And some in a nasal spray:
PT-141/Oxytocin/L-Theanine 2.5mg/20IU/10mg/0.1mL Nasal Spray 3mL.

If you could get a physician to work with them they could probably compound it for you. Disappointing that Defy doesn't work with them.

 

[MDavidW76]

I’m trying oxytocin

 

[BadassBlues]

I’m trying oxytocin

Troches or nasal spray? Post your experience and thoughts.

 

[MDavidW76]

Order just went to the compounding pharmacy, nasal pump, I’ll see how it goes when I get it.

 

[brookseth]

For people who get bad stuffy nose with PE5 - would taking it intranasal theoretically make that an even worse effect? That's always been my issue with taking them - no matter what I need Afrin to breathe regardless of dose.

 

[M.J]

This sounds very interesting, recently I have been having a really hard time finishing with my wife, it’s totally not her, it’s me, and I have no idea why…

This last month we’ve been going at it like we did when we were teenagers and there’s no real ground rules from her, it’s pretty much “you can use my entire body to pleasure yourself”… turns out she has been neglecting to mention some really hot and dirty things she’s thought about and is totally into…

I’m fully on board, but I just cannot believe I cannot finish. It’s frustrating the both of us!

Same thing here finishing is impossible unless I use my own hand :/

I saw improvement with Wellbutrin in many aspects. But finishing the job with my wife is difficult. A bit better though than before.

 

[BadassBlues]

Several sources for the PDE5i plus Apomorphine in troche form. It looks like Empower has one. I would really like to try this combo.

*** Update. I just did an online with Defy to get a script from Empower.

 

[MDavidW76]

Troches or nasal spray? Post your experience and thoughts.

Sorry I did not get back to this thread… it was oxytocin troches, they made me flush and stuffy, I was able to finish, I was throwing ropes like I did when I was a young buck… my wife loves watching them firing off… what I found was that a day later I was feeling really sad for no reason at all after taking the troches. I may try again with the spray, but feeling sad ai t worth it.

 

[Mastodont]

For people who get bad stuffy nose with PE5 - would taking it intranasal theoretically make that an even worse effect? That's always been my issue with taking them - no matter what I need Afrin to breathe regardless of dose.

I was going to say the same, sounds like a surefire way to mouthbreathing