My results on daily prop 11mg SQ
- Thread starter Steve78
- Start date
Just to be healthier, scared about prostate cancer, long term supraphysiologic levels etc
Vince
Super Moderator
AI Overview
Men with lower levels of free testosterone have a reduced risk of developing prostate cancer, but men with very low levels who do develop prostate cancer are more likely to have an aggressive form of the disease:
pmc.ncbi.nlm.nih.gov
Men with lower levels of free testosterone have a reduced risk of developing prostate cancer, but men with very low levels who do develop prostate cancer are more likely to have an aggressive form of the disease:
- Risk reduction
Men with the lowest levels of testosterone have a 23% lower risk of developing prostate cancer.
- Risk of high-grade disease
Men with low testosterone levels have a nonsignificantly higher risk of developing high-grade prostate cancer.
- Testosterone and prostate cancer growth
Prostate cancer needs testosterone to grow, and once testosterone levels rise above a low level, further increases in testosterone do not increase prostate growth.
- Androgen receptors
The body has a limited number of androgen receptors, the proteins that bind testosterone to activate it. Once these receptors are full, additional testosterone in the blood can't bind and activate them, so it doesn't increase the risk of developing prostate cancer.
Testosterone and prostate cancer: an evidence-based review of pathogenesis and oncologic risk - PMC
Testosterone plays a central role in male development and health. Likewise, androgen deficiency, or hypogonadism, is associated with a variety of symptoms including decreased energy, diminished libido and erectile dysfunction, among others. Male ...
pmc.ncbi.nlm.nih.gov
No libido issues. But if I lower dose I think estrogen will decrease. I’ll drop to 8 mg and recheck
t_spacemonkey
Well-Known Member
you need to get your blood drawn BEFORE the injection and not after, which is what appears to be. i highly doubt your e2 will move. this is all individual but personally i would feel worse then without any TRT on that dose. so you think that going from 11 to 8 will make you healthier?
Ignore naysayers and give it a try. The lower dose is still giving you as much or more testosterone than the average healthy young guy makes. Just be aware of a transition period in which your body adapts to the new dose. I'm doing great on the equivalent of 5.25 mg TP daily. This wouldn't be considered very unusual if more guys were using a low-and-slow approach to dosing; it's only about one standard deviation below the healthy-young-male average.
It’s test prop, so yea I think 7 am injection it was a good idea to check at 3pm, as I inject daily. And yes I think lowering my free testosterone to normal ranges is healthier, what am I missing here?
t_spacemonkey
Well-Known Member
you blood work was at peak(ish). prop has high peak/low low. you need to blood work in the morning before injection. there is a reasons most clinics have patients in the 120-180mg range on TRT. again - all individual - so if you do great on a low dose, not dismissing it by any means go for it.
you can also argue that at those low doses TRT does not make a lot of sense, as most people can achieve those levels naturally by modifying diet/lifestyle. chasing any lab is pointless. on the flip side, on such doses you will miss out on many of the TRT benefits, raised DHT (especially with Prop), some anabolism etc. I experimented with many esters, doses and regimens, and function the best at 25-30mg Tprop daily. yes this is outside of what you natural would achieve, but who gives a shit? I have yet to see credible evidence that this is problematic
What about the increase in prostate cancer with higher free T?
Also, isn’t dose irrelevant, the labs (ie total T etc) are more of a guide for trt? I did a single shot of 200 mg test cyp and 5 days after inject my total testosterone was 2100!
Phil Goodman
Well-Known Member
Can you share the studies that showed a higher level of free t increased the risk for prostate cancer?
Serum testosterone and the risk of prostate cancer: potential implications for testosterone therapy - PubMed
Higher levels of calculated serum free testosterone are associated with an increased risk of prostate cancer. These findings suggest that men receiving testosterone therapy should be regularly monitored for prostate cancer and underscore the need for prospective trials of testosterone therapy...
pubmed.ncbi.nlm.nih.gov
Vince
Super Moderator
Could More Testosterone Be the Hidden Key to Fighting Prostate Cancer?
Androgen deprivation therapy (ADT) has been the bedrock of treatment for advanced prostate cancer for more than half a century. But investigators at Johns Hopkins are rethinking it – in a way that sounds counterintuitive – and driving new approaches to tackle treatment resistance. They’re...
www.pcf.org
Vince
Super Moderator
To date, the limited number of prostate cancer cases within cohort studies meant it was not possible to assess how IGF-1 and free testosterone affect the risk of different types of prostate cancer, particularly aggressive forms of the disease.
Furthermore, it was not clear whether these hormones directly increase prostate cancer risk, or if they are merely linked to a different factor which is the true cause. It was also possible that these associations were the result of reverse causation, where preclinical cancer symptoms caused the hormone levels to change before the disease was diagnosed.
Furthermore, it was not clear whether these hormones directly increase prostate cancer risk, or if they are merely linked to a different factor which is the true cause. It was also possible that these associations were the result of reverse causation, where preclinical cancer symptoms caused the hormone levels to change before the disease was diagnosed.
Phil Goodman
Well-Known Member
Thanks.
Serum testosterone and the risk of prostate cancer: potential implications for testosterone therapy - PubMed
Higher levels of calculated serum free testosterone are associated with an increased risk of prostate cancer. These findings suggest that men receiving testosterone therapy should be regularly monitored for prostate cancer and underscore the need for prospective trials of testosterone therapy...
I guess like with so many other things, there are conflicting studies out there.
Study: Testosterone therapy does not raise prostate cancer risk - UW Medicine | Newsroom
Review of nearly 150,000 patient cases provides strong evidence, says UW Medicine urologist who led research.
newsroom.uw.edu
Appropriate use of testosterone therapy does not appear to raise prostate cancer risk - Harvard Health
A 2023 study confirms prior research showing that men with low testosterone levels who use testosterone replacement therapy for 14 months are not at a higher risk for prostate cancer over the follo...
www.health.harvard.edu
I wonder if estrogen is the cause? Not sure. One thing I find with prostate cancer is most of the people I know who have prostate cancer have 2 things in common, huge guts and jobs that required a lot of sitting…. Maybe that causes the inflammation that triggers the cancer
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