The last time I started on a transdermal I went and got tested when I was in the sweet spot after about 10 days, I was feeling really good and libido was high, no ED. My test. was 453, range 241-827; Free T was 5.7, range 3.8-34.2. Now my T and Free T are near the top of the range and my libido is almost zero and I have ED problems. Estrogen is 28 on the sensitive E2 test, but just in case I've trialed some low dose Arimidex to no effect.
Like I said, I never got this libido boost when starting injections, so I have to ask if T and Free T aren't what caused the libido boost on transdermals then what is? Well DHT is one possibility, I wonder if I have a sweet spot for DHT that is I am lower or higher my libido tanks. Could also be something like the ratio of hormones since when I am in the sweet spot my hormone levels are still changing and adjusting.
As far as injecting twice a week, I've read about guys doing something like Sat. morning and Tuesday night. Maybe people more experienced with injections can comment.