My journey so far -- a year of Labs and attempts to relieve symptoms. Pls Help

[jpw1585]

Inflammation is what drives SHBG down, overexertion, stress will trigger RA.

Vitamin K decreases inflammation, so might want to check to see where your levels are.

Excellent. Thanks for the reply.

So in theory, living w RA and it’s chronic elevated inflammation, it’s likely that my SHBG will be perpetually low.

So if going on TRT+HCG, it would be imperative to start on the conservative end of dose with very frequent injections?

@Systemlord arent you the Jatenzo guy? My doc is a fan. Does it’s short half life benefit folks w low SHBG ?

Is the vitamin k you reference k2?

 

[Systemlord]

So if going on TRT+HCG, it would be imperative to start on the conservative end of dose with very frequent injections?

I would inject frequently, smaller doses daily.

@Systemlord arent you the Jatenzo guy? My doc is a fan.

Yes, Jatenzo @ 237 mg twice daily, which is the recommended starting dosage. I get a level of consistency I never got on other treatments. My Total T levels peak in 2 hours and decline 100 ng/dL every hour.

Does it’s short half life benefit folks w low SHBG ?

My SHBG is about the same as it was on injections. 17-24. My SHBG has increased on TRT because I have Type 2 diabetes, previously 11. TRT improves the symptoms of diabetes so it’s not uncommon to see an increase in SHBG.

As I improve my diabetes further, my SHBG may go up even more.

 

[jpw1585]

I would inject frequently, smaller doses daily.

Yes, Jatenzo @ 237 mg twice daily, which is the recommended starting dosage. I get a level of consistency I never got on other treatments. My Total T levels peak in 2 hours and decline 100 ng/dL every hour.


My SHBG is about the same as it was on injections. 17-24. My SHBG has increased on TRT because I have Type 2 diabetes, previously 11. TRT improves the symptoms of diabetes so it’s not uncommon to see an increase in SHBG.

As I improve my diabetes further, my SHBG may go up even more.

Awesome!

So with Jatenzo… do you “feel” the peaks and valleys… as they are pretty much happening in real time everyday?

Is there a point in time, with consistent administration, where you are in a “steady state”. I know obviously it changes hourly… but does the brain and body know that… or at some point, do you just feel like you have optimal T levels?

How has your libido been on this, whilst also dealing w low-ish SHBG / insulin issues?

 

[Systemlord]

So with Jatenzo… do you “feel” the peaks and valleys…

No, I feel no peaks and valleys beyond 7 days. Jatenzo reaches steady states in 7 days, dialing in is fast as easy!

I feel like my testosterone levels are optimal in 7 days! I could go through three dosage increases, reach a steady state three separate times, and compared to a guy on injections having 3 more weeks to reach steady states on Only to find out the levels are either too high or too low, then having to start over again.

Another 6 weeks to a steady state. This is the difference between dialing in on injections taking 3, 6, or 9 months to a couple of weeks on Jatenzo!

How has your libido been on this, whilst also dealing w low-ish SHBG / insulin issues?

My libido went down since stopping Jardiance, which caused dehydration and elevated hematocrit and hemoglobin. Cialis is doing more for me than Jardiance could ever hope to. Also, I’m starting to believe some of my problems with erections are libido are E2 related.

I think that’s why Cialis is doing more for me than Jardiance, because it inhibits aromatase which converts T->E2. A lot of my improvements closely trend with E2 related changes or reduction in symptoms.

 

[Systemlord]

My Experience On Jatenzo (Oral TRT) Log

I wanted to start a thread detailing my personal experience with Jatenzo (oral TRT) which is remarkable in how quickly it has shown results when compared with injections. The first week on Jatenzo was very pleasant unlike my experience after dosing changes on injections, all with minimal swings...

www.excelmale.com

 

[jpw1585]

No, I feel no peaks and valleys beyond 7 days. Jatenzo reaches steady states in 7 days, dialing in is fast as easy!

I feel like my testosterone levels are optimal in 7 days! I could go through three dosage increases, reach a steady state three separate times, and compared to a guy on injections having 3 more weeks to reach steady states on Only to find out the levels are either too high or too low, then having to start over again.

Another 6 weeks to a steady state. This is the difference between dialing in on injections taking 3, 6, or 9 months to a couple of weeks on Jatenzo!

My libido went down since stopping Jardiance, which caused dehydration and elevated hematocrit and hemoglobin. Cialis is doing more for me than Jardiance could ever hope to. Also, I’m starting to believe some of my problems with erections are libido are E2 related.

I think that’s why Cialis is doing more for me than Jardiance, because it inhibits aromatase which converts T->E2. A lot of my improvements closely trend with E2 related changes or reduction in symptoms.

Agreed.

Both times I have tried SERMs, they are great for a couple weeks or so… then dog shit.

My e2 got to 77 on enclo and I literally couldn’t even think about sex. If I forced myself to, it felt like thinking about water polo or concrete. Two things I could care less about.

Low SHBG, high and untouchable aromatase in the testes.

Thus why, I am heavily heavily contemplating TRT and HCG of one protocol or another.

Urologist is a big fan of Jatenzo and pushing for that and HCG.

My worries w HCG are that it’s similar to enclo where there is a ton of e2 production in the testes.

Sounds like, for you, Jatenzo has been great.

Seems like if I’m gonna inject HCG then what’s the big deal about injecting T too… but if there are other advantages to Jatenzo… then why not less overall injections.

Doc already prescribed it, but we don’t meet for a few weeks to “pull the trigger” on TRT options.

 

[Systemlord]

I typically eat a spoonful of organic peanut butter with or without a meal, together with my Jatenzo.

Fats help you absorb Jatenzo.

 

[jpw1585]

I typically eat a spoonful of organic peanut butter with or without a meal, together with my Jatenzo.

Fats help you absorb Jatenzo.

Thanks for the insight.

You said you were T2D… what’s your SHBG ?

I’d imagine lower end of the spectrum?

Jatenzo and lower SHBG… how has that impacted for FT, e2, PRL, and DHT?

Symptom wise… how’s libido.

That has been the frustrating thing for me. W low SHBG… e2 and PRL seem to increase at a disproportionate pace on enclo

I know taking T is a whole different vector but I will be adding HCG into the mix which then brings back testicular aromatase to some extent.

 

[Systemlord]

You said you were T2D… what’s your SHBG ?

SHBG was 11 and is now 17-24. I believe it will continue to increase higher as I lose more weight.

Jatenzo and lower SHBG… how has that impacted for FT, e2, PRL, and DHT?

Halving your SHBG doesn’t really change the Free T much at all.

Symptom wise… how’s libido.

Libido has never really been a big problem for me, up until now it was the plumbing that wasn’t up to par. Many people don’t know the difference between libido and arousal. Libido is in the brain, erections, arousal is a physical reaction.

 

[jpw1585]

SHBG was 11 and is now 17-24. I believe it will continue to increase higher as I lose more weight.

Halving your SHBG doesn’t really change the Free T much at all.


Libido has never really been a big problem for me, up until now it was the plumbing that wasn’t up to par. Many people don’t know the difference between libido and arousal. Libido is in the brain, erections, arousal is a physical reaction.

On point 2… if one has low SHBG, they will tend to disproportionately aromatize to E2 + metabolize the T quicker … aka not get the same symptom relief as someone w normal SHBG… is that right?

If that is correct, I think that explains my shitty results w enclo

I have heard the same for people that have low SHBG and do less frequent / big doses of injections

Was curious if Jatenzo’s twice a day administration more closely mimicked the ED injection cadence in terms of minimizing e2 sides and getting the most out of it… aka microdosing.

Even on enclo, before the intratesticular aromatase got out of control… my libido and arousal was on point. Handing a lot fuller as well.

 

[Systemlord]

If that is correct, I think that explains my shitty results w enclo

Lots of people have sh*** results on clomid.