I changed my anastrazole dosing 3 days ago from daily to .25mg weekly and the muscle soreness has virtually disappeared, (a small amount still lingering, but it may for a while). I consulted my doctor about the sensitivity level of my E2 assay and requested a "ultra sensitive" E2 assay on 22 Dec, she concurred. I can adjust as needed upon receiving those results. Thank you so much for replying to my post.
Muscle soreness is one of a number of negative sides to suppressed estrogen serum levels.
.25 mg each night is way way too much!
That could be a weekly dose NOT daily.