Men's Use of Oxytocin

[Neil Olson]

Anybody have experience with oxytocin replacement? My understanding is it is fairly new. I figure with my pituitary problems it may be worth checking out.

 

[Nelson Vergel]

I took it and did not feel anything different. But I have a friend who becomes nicer to everyone when he takes it.

Oxytocin "The love hormone"
Daily Oxytocin doses. Any correlation to lactation in men?

 

[indydaddy]

I ordered some Oxytocin. Just waiting on the right moment for my partner and I to try it. I have witnessed the profound effect it has on mother and newborn baby bonding in the delivery room. I think you could show the new mother a shoe and tell her it was her baby and she would love it.

Having difficulty determining the correct dose to take. The doses are all in I.U. , while the Oxytocin is in mg/ml.

 

[Neil Olson]

Have you guys been diagnosed with a deficiency or did you order a peptide?

 

[Jasen Bruce]

Much like herbal or nutritional supplements, Oxytocin can work for some and have no effect in others. Some people have reported experiencing subtle content to overall euphoria with the nasal spray. Others have felt nothing, or at least anything worth reporting. The differences probably depend on a combination of absorption, metabolism, and deficiency (if any).

It only works by nasal spray or injection. Injection is not suggested since it can have unwanted side effects.

Here is something interesting I found:

A nasal spray formulation of oxytocin branded Syntocinon isunder development by Retrophin for the treatment of lactation deficiency and asa novel treatment for autism and schizophrenia.[12] As of October 2014, it hasreached phase III, phase II, and phase II clinical trials for theseindications, respectively.[13] In October 2014, Retrophin divested Syntocinonto Turing Pharmaceuticals.

Here is another article on Oxytocin: http://defymedical.com/resources/health-articles/96-oxytocin-improves-sex-sociability-and-mood

Lastly, here is a very trippy but informational site on Oxytocin: www.oxytocin.org

 

[Keith Willse]

I have used Oxytocin for years and I absolutely love it! It currently is and always will be a staple in my regimen. The most pronounced benefit I feel and others will attest is “Mood Enhancement” In short, I just interact better with everyone while using Oxytocin.


While there are several formulations available and conflicting information on administration routes, I have found SR capsules work best for me.

Here is some good information on Oxytocin.

Oxytocin is a very abundant neuropeptide exerting a wide spectrum of central and peripheral effects as neurohormone, neurotransmitter, or neuromodulator. In the central nervous system, the oxytocin gene is predominantly expressed in magnocellular neurons in the hypothalamic paraventricular (PVN) and supraoptic (SON) nuclei. The magnocellular oxytocin neurons release their products into the general circulation in the neurohypophysis while the mediocellular oxytocin neurons secrete elsewhere in the CNS. Oxytocin is also produced in peripheral tissues, e.g., uterus, placenta, amnion, corpus luteum, testis, and heart. The typical actions of peripheral oxytocin are stimulation of uterine smooth muscle contraction during labor and milk ejection during lactation. Oxytocin receptors have also been identified in other tissues, including the kidney, heart, thymus, pancreas, and adipocytes.

“Oxytocin is a potent stimulator of spontaneous erections in rats and is involved in ejaculation. “

http://www.ncbi.nlm.nih.gov/pubmed/11274341

 

[Neil Olson]

I have used Oxytocin for years and I absolutely love it! It currently is and always will be a staple in my regimen. The most pronounced benefit I feel and others will attest is “Mood Enhancement” In short, I just interact better with everyone while using Oxytocin.


While there are several formulations available and conflicting information on administration routes, I have found SR capsules work best for me.

Here is some good information on Oxytocin.

Oxytocin is a very abundant neuropeptide exerting a wide spectrum of central and peripheral effects as neurohormone, neurotransmitter, or neuromodulator. In the central nervous system, the oxytocin gene is predominantly expressed in magnocellular neurons in the hypothalamic paraventricular (PVN) and supraoptic (SON) nuclei. The magnocellular oxytocin neurons release their products into the general circulation in the neurohypophysis while the mediocellular oxytocin neurons secrete elsewhere in the CNS. Oxytocin is also produced in peripheral tissues, e.g., uterus, placenta, amnion, corpus luteum, testis, and heart. The typical actions of peripheral oxytocin are stimulation of uterine smooth muscle contraction during labor and milk ejection during lactation. Oxytocin receptors have also been identified in other tissues, including the kidney, heart, thymus, pancreas, and adipocytes.

“Oxytocin is a potent stimulator of spontaneous erections in rats and is involved in ejaculation. “

http://www.ncbi.nlm.nih.gov/pubmed/11274341

Keith does your doctor prescribe it to you? I think I am going to ask my endocrinologist. She seems pretty receptive.

 

[Keith Willse]

Yes my doctor writes the RX.

 

[Neil Olson]

Low oxytocin questionaire

http://cabecahealth.com/articles/assessing_oxytocin_sufficiency.pdf

 

[Neil Olson]

So I have been unsuccessful in my attempts to get a prescription. My endo has no experience with it and my primary refuses to. Quite a few people who are panhypopituitary like me have been able to get prescriptions. They are experiencing lots of improvement in their quality of life.

http://neuro.psychiatryonline.org/doi/pdfplus/10.1176/jnp.17.2.159

http://www.ncbi.nlm.nih.gov/pubmed/21980491

http://www.ncbi.nlm.nih.gov/pubmed/25282363

 

[Jasen Bruce]

Hi Neil, if you cannot obtain an Rx locally you can contact Defy Medical-a telemedicine service that will provide the doctor consultation by phone and a prescription for Oxytocin, usually in the form of a compounded nasal spray however the sublingual is also available.

 

[Neil Olson]

Thanks. I may do that.

 

[Neil Olson]

Finally quit begging my local doctor and filed out the paperwork for Defy. My endo is not against me trying it, but she has no experience so she was reluctant to prescribe it.

 

[Nelson Vergel]

The dark side of the 'love hormone'; similarities with the effects of alcohol


Dr Ian Mitchell, from the School of Psychology at the University of Birmingham, explained, "We thought it was an area worth exploring, so we pooled existing research into the effects of both oxytocin and alcohol and were struck by the incredible similarities between the two compounds."

"They appear to target different receptors within the brain, but cause common actions on GABA transmission in the prefrontal cortex and the limbic structures. These neural circuits control how we perceive stress or anxiety, especially in social situations such as interviews, or perhaps even plucking up the courage to ask somebody on a date. Taking compounds such as oxytocin and alcohol can make these situations seem less daunting."
The team acknowledge that the ability to inhibit anxieties could explain the temptation to summon a little 'Dutch courage' - particularly in the context of social situations such a first date. Dr Steven Gillespie said, "The idea of 'Dutch courage' - having a drink to overcome nerves - is used to battle those immediate obstacles of fear and anxiety. Oxytocin appears to mirror these effects in the lab."


When administered nasally, oxytocin appears to closely mirror the well-established effects of alcohol consumption. However the researchers warn against self-medicating with either the hormone or a swift drink to provide a little more confidence in difficult moments.

http://www.medicalnewstoday.com/releases/294168.php?tw

 

[Nelson Vergel]

Oxytocin may improve metabolic control in men with obesityThienel M, et al. Int J Obes. 2016;doi:10.1038/ijo.2016.149.



'We demonstrate that the acute intranasal administration of oxytocin inhibits reward-[driven] but also hunger-driven food intake in obese men and that this effect is not compensated for by changes in energy expenditure,” Matthias Thienel, a doctoral student at the Institute for Medical Psychology and Behavioural Neurobiology at the University of Tubingen, Germany, and colleagues wrote. “In normal-weight men, the oxytocin-induced reduction in calorie consumption was restricted to snacking, indicating that the inhibitory effect of oxytocin on food intake is generally larger in obese than normal-weight subjects.”

 

[Loki]

Dr. Saya curious if this would help me... Brought some issues up in my last consult. Should we schedule another consult or discuss over email to order?

 

[Will Brink]

The dark side of the 'love hormone'; similarities with the effects of alcohol


Dr Ian Mitchell, from the School of Psychology at the University of Birmingham, explained, "We thought it was an area worth exploring, so we pooled existing research into the effects of both oxytocin and alcohol and were struck by the incredible similarities between the two compounds."

"They appear to target different receptors within the brain, but cause common actions on GABA transmission in the prefrontal cortex and the limbic structures. These neural circuits control how we perceive stress or anxiety, especially in social situations such as interviews, or perhaps even plucking up the courage to ask somebody on a date. Taking compounds such as oxytocin and alcohol can make these situations seem less daunting."
The team acknowledge that the ability to inhibit anxieties could explain the temptation to summon a little 'Dutch courage' - particularly in the context of social situations such a first date. Dr Steven Gillespie said, "The idea of 'Dutch courage' - having a drink to overcome nerves - is used to battle those immediate obstacles of fear and anxiety. Oxytocin appears to mirror these effects in the lab."


When administered nasally, oxytocin appears to closely mirror the well-established effects of alcohol consumption. However the researchers warn against self-medicating with either the hormone or a swift drink to provide a little more confidence in difficult moments.

The dark side of the 'love hormone'; similarities with the effects of alcohol

Ok, so do I use the oxytocin before I start drinking or after? Sounds like fun to me!

 

[Nelson Vergel]

Higher Oxytocin Levels Seen in Men With Hypersexual Disorder

Cognitive behavioral therapy lessened those hormone levels

www.medpagetoday.com