Men with this Genetic Mutation Do Better on TRT

[Nelson Vergel]

Interesting data on certain genetic mutations as they can predict whose body composition will be better on TRT

Bone and body composition response to testosterone therapy vary according to polymorphisms in the CYP19A1 gene - PubMed

For the first time, we demonstrated that CYP19A1 SNPs influence response to testosterone therapy in hypogonadal men, highlighting the importance of genetic profiling in therapeutics even for common clinical conditions.

pubmed.ncbi.nlm.nih.gov

 

[DorianGray]

Good post Nelson. Inspired me to check my raw data on 23andMe. Luckily, I have the CC and CG variants more favorable.

 

[Marco N Cognito]

"Body composition analysis showed that the CC genotype of rs1062033, and the AA genotype of rs700518, had significant increase in total lean and appendicular lean mass compared to CG and GG, and AG and GG, respectively."

I won the genetic lottery on this one! I am CC and TT (AA) respectively (for 23andMe.com users, you have to re-orient the SNP for rs700518).

 

[ajax31]

"Body composition analysis showed that the CC genotype of rs1062033, and the AA genotype of rs700518, had significant increase in total lean and appendicular lean mass compared to CG and GG, and AG and GG, respectively."

I won the genetic lottery on this one! I am CC and TT (AA) respectively (for 23andMe.com users, you have to re-orient the SNP for rs700518).

I looked at my raw data on 23andMe for this SNP, and it shows "Your Genotype" as C/T. I'm not sure how to interpret that.

 

[Marco N Cognito]

I looked at my raw data on 23andMe for this SNP, and it shows "Your Genotype" as C/T. I'm not sure how to interpret that.

Orientation - SNPedia

www.snpedia.com

 

[TestOneTwo]

Aww man...

 

[Robotics]

"Body composition analysis showed that the CC genotype of rs1062033, and the AA genotype of rs700518, had significant increase in total lean and appendicular lean mass compared to CG and GG, and AG and GG, respectively."

I won the genetic lottery on this one! I am CC and TT (AA) respectively (for 23andMe.com users, you have to re-orient the SNP for rs700518).

how is your body composition?

 

[Nelson Vergel]

New mutation causing androgen insensitivity syndrome – a case report and review of literature

ABSTRACT Androgen insensitivity syndrome (AIS) is a congenital disorder in which a defect in the androgen receptor (AR) gene leads to cellular resistance to androgens. Defects in the AR gene, located on the X chromosome, result in the development of a feminine phenotype in chromosomally male...

www.excelmale.com

 

[Nelson Vergel]

Men who are slow testosterone metabolizers due to a gene mutation are leaner.

Zhu AZ, Cox LS, Ahluwalia JS, et al. Genetic and phenotypic variation in UGT2B17, a testosterone-metabolizing enzyme, is associated with BMI in males. Pharmacogenet Genomics...

www.excelmale.com

 

[Marco N Cognito]

how is your body composition?

Never as good as I want it, but not on TRT currently. This news adds more fuel to the pro-TRT fire for me though.

 

[TestOneTwo]

200mg every 2 weeks...? I wonder whether the differences were far milder if any by simply employing a more beneficial protocol. Maybe this was simply a matter of which gene expression is more forgiving and allows for a good body composition results even under pretty bad conditions (poor protocol) rather than ideal conditions (good protocol)?