Lp(a) [Lipoprotein(a)] - the hidden killer lipid marker

[Gianluca]

2020
My issue was always massively raised Lp(a) in the LDL-c partition.
(Heterozygous Fh)

before Nandrolone decanoate added to trt protocol
2.64 micromol/l

after 8weeks ND + test cyp (30mg/60mg) qwk outlier.

1.435 micromol/l

almost in range for first time in my life. (Interestingly, atorvastatin therpy had it over 3.0 !)

I’m considering adding oxandrolone in microdose, in addition to the microdose of ND in attempt to attenuate Lp(a) further.

wow, very interesting, how is your SFa intake? SFA reduce Lp(a) especially those coming from Coconut oil

 

[bp]

wow, very interesting, how is your SFa intake? SFA reduce Lp(a) especially those coming from Coconut oil

I only consume saturated fats. No pufas.

 

[Marco N Cognito]

I only consume saturated fats. No pufas.

What about n-3's (i.e. marine lipids)?

 

[bp]

What about n-3's (i.e. marine lipids)?

No, i dont touch them. No omega-3 or -6
The peroxidation is dreadful in fat and tissue.

The research ive read on this topic over the years terrified me tbh.

The majority of the reason theyre deemed ‘heart healthy’ is the effect on lipid metabolism, but most of this is due to liver toxicity, plus, the idea of HDL being the ‘good cholesterol’ is now being reconsidered, and refuted by some in the field. Which interess me greatly.

Ive yet to see a paper of value which substantiates the claim that the EPA & DHA are beneficial to the endothelial lining.

Although i keep looking.

They're extremely suppressive to thyroid function too, which is of concern, as i desire to be euthyroid, to ensure my LDL receptors are at max.

Dr Ray Peat seems to be on the money.

I think its possibly one of the biggest health scams going. (Omega -3)

Im open minded to any info though.

 

[Gianluca]

No, i dont touch them. No omega-3 or -6
The peroxidation is dreadful in fat and tissue.

The research ive read on this topic over the years terrified me tbh.

The majority of the reason theyre deemed ‘heart healthy’ is the effect on lipid metabolism, but most of this is due to liver toxicity, plus, the idea of HDL being the ‘good cholesterol’ is now being reconsidered, and refuted by some in the field. Which interess me greatly.

Ive yet to see a paper of value which substantiates the claim that the EPA & DHA are beneficial to the endothelial lining.

Although i keep looking.

They're extremely suppressive to thyroid function too, which is of concern, as i desire to be euthyroid, to ensure my LDL receptors are at max.

Dr Ray Peat seems to be on the money.

I think its possibly one of the biggest health scams going. (Omega -3)

Im open minded to any info though.

I used Fish Oil for years, but came across probably the same data about lipid peroxidation and decided to stop it a bit over two months ago. I'm recommending Grass Fed Meats and Fish to get some Omegas 3, and that'it. I think an Omega Index can still be useful to determine EPA/AA/DHA intake, but the less Omega 6 we consume, the less Omega 3 we need

 

[Marco N Cognito]

Ive yet to see a paper of value which substantiates the claim that the EPA & DHA are beneficial to the endothelial lining.

supportive:

Frontiers | Omega-3 Fatty Acid Supplementation Improves Endothelial Function in Primary Antiphospholipid Syndrome: A Small-Scale Randomized Double-Blind Placebo-Controlled Trial

Endothelial cells are thought to play a central role in the pathogenesis of antiphospholipid syndrome (APS). Omega-3 polyunsaturated fatty acid (n-3 PUFA) su...

www.frontiersin.org

omega 3 fatty acids endothelial dysfunction - Google Search

Omega 3 Polyunsaturated Fatty Acids Improve Endothelial Dysfunction in Chronic Renal Failure: Role of eNOS Activation and of Oxidative Stress

Background: Endothelial dysfunction is a key vascular alteration in chronic kidney disease (CKD). Omega 3 (n-3) polyunsaturated fatty acids (PUFA) reduce vascular oxidative stress and inflammation. We investigated whether n-3 PUFA could reverse endothelial ...

www.ncbi.nlm.nih.gov

Omega-3 Polyunsaturated Fatty Acids: Structural and Functional Effects on the Vascular Wall

Omega-3 polyunsaturated fatty acids (n-3 PUFA) consumption is associated with reduced cardiovascular disease risk. Increasing evidence demonstrating a beneficial effect of n-3 PUFA on arterial wall properties is progressively emerging. We reviewed the recent available evidence for the...

www.hindawi.com

Docosahexaenoic acid regulates vascular endothelial cell function and prevents cardiovascular disease - Lipids in Health and Disease

Docosahexaenoic acid (DHA) is present in high concentrations in salmon, herring, and trout. Epidemiologic studies have shown that high dietary consumption of these and other oily fish is associated with reduced rates of myocardial infarction, atherosclerosis, and other ischemic pathologies...

lipidworld.biomedcentral.com

Fish oil and vascular endothelial protection: Bench to bedside | Request PDF

Request PDF | Fish oil and vascular endothelial protection: Bench to bedside | Fish oil is recommended for the management of hypertriglyceridemia and to prevent secondary cardiovascular disorders. Fish oil is a major source... | Find, read and cite all the research you need on ResearchGate

www.researchgate.net

no effect:

https://www.atherosclerosis-journal.com/article/S0021-9150(18)30104-7/pdf

Effect of ω-3 fatty acid supplementation on endothelial function, endogenous fibrinolysis and platelet activation in patients with a previous myocardial infarction: a randomised controlled trial | BMJ Open

 

[Vince]

I used Fish Oil for years, but came across probably the same data about lipid peroxidation and decided to stop it a bit over two months ago. I'm recommending Grass Fed Meats and Fish to get some Omegas 3, and that'it. I think an Omega Index can still be useful to determine EPA/AA/DHA intake, but the less Omega 6 we consume, the less Omega 3 we need

I've always wondered if the main benefit of fish oil is the effect it has on our blood? Making it more slippery, easier to flow through narrow arteries.

 

[Gianluca]

I've always wondered if the main benefit of fish oil is the effect it has on our blood? Making it more slippery, easier to flow through narrow arteries.

and possibly lowering inflammation markers

 

[bp]

supportive:

Frontiers | Omega-3 Fatty Acid Supplementation Improves Endothelial Function in Primary Antiphospholipid Syndrome: A Small-Scale Randomized Double-Blind Placebo-Controlled Trial

Endothelial cells are thought to play a central role in the pathogenesis of antiphospholipid syndrome (APS). Omega-3 polyunsaturated fatty acid (n-3 PUFA) su...

www.frontiersin.org

omega 3 fatty acids endothelial dysfunction - Google Search

Omega 3 Polyunsaturated Fatty Acids Improve Endothelial Dysfunction in Chronic Renal Failure: Role of eNOS Activation and of Oxidative Stress

Background: Endothelial dysfunction is a key vascular alteration in chronic kidney disease (CKD). Omega 3 (n-3) polyunsaturated fatty acids (PUFA) reduce vascular oxidative stress and inflammation. We investigated whether n-3 PUFA could reverse endothelial ...

www.ncbi.nlm.nih.gov

Omega-3 Polyunsaturated Fatty Acids: Structural and Functional Effects on the Vascular Wall

Omega-3 polyunsaturated fatty acids (n-3 PUFA) consumption is associated with reduced cardiovascular disease risk. Increasing evidence demonstrating a beneficial effect of n-3 PUFA on arterial wall properties is progressively emerging. We reviewed the recent available evidence for the...

www.hindawi.com

Docosahexaenoic acid regulates vascular endothelial cell function and prevents cardiovascular disease - Lipids in Health and Disease

Docosahexaenoic acid (DHA) is present in high concentrations in salmon, herring, and trout. Epidemiologic studies have shown that high dietary consumption of these and other oily fish is associated with reduced rates of myocardial infarction, atherosclerosis, and other ischemic pathologies...

lipidworld.biomedcentral.com

Fish oil and vascular endothelial protection: Bench to bedside | Request PDF

Request PDF | Fish oil and vascular endothelial protection: Bench to bedside | Fish oil is recommended for the management of hypertriglyceridemia and to prevent secondary cardiovascular disorders. Fish oil is a major source... | Find, read and cite all the research you need on ResearchGate

www.researchgate.net

no effect:

https://www.atherosclerosis-journal.com/article/S0021-9150(18)30104-7/pdf

Effect of ω-3 fatty acid supplementation on endothelial function, endogenous fibrinolysis and platelet activation in patients with a previous myocardial infarction: a randomised controlled trial | BMJ Open

I’ve got, I think, over 300 that show the opposite,..I’ll dig them out tomorrow.

 

[bp]

and possibly lowering inflammation markers

All my inflammation markers rose when I ate a high fatty fish diet.
Sardines, salmon, mackerel.

I think that if it is consumed, It must be from a whole food source such as the fish itself.
The very nature of omega -3 and it’s properties, puts it as liquid at room temp, and therefore highly susceptible to oxidation.
It’s generally rancid in liquid form. (Fish oil in bottles, in capsules). Highly toxic. I wouldn’t touch it as a supplement. As a whole food it’s another level entirely.