With my T Cyp 50mg injections E3.5D, I also pinned 500iu HCG E3.5D for about 6mos. Other than full testicles, I really felt no additional benefit of the higher dose and also ended up having to add a low dose AI due to my E rising. I had symptoms of sore nipples, water bloat, night sweats....was miserable testing out at Sensitive E2 at 52. Changed my protocol about 8 weeks ago. I went to 250iu HCG E3.5D, stopped the AI and my testicles have not shrunk at all, with my sensitive E2 dropping from 52 to 38 .....no high E2 symptoms or need to take the AI any longer at this point. We are all different, but I believe this is the right level for me and my labs and how I am feeling are in line with that thought. I have no need for fertility at 51, just don't like the thought and pain of organ failure.