Lower back pain

[Scottmcty]

My bloods before Cialis where above range

I’ve not had bloods taken while on Cialis as find it hard to get time off to get them

But had them done last week , but labs messed them up come back not tested on most of the readings .


I know I still get high e2 after a while

I tryed dropping my test dose Lower then 122 but feel like crap

I’ve tried hcg and can never get dialled on as well

So dropped it as don’t want kids as been there and done that .

If i use a ai I feel like shit

I was using a small dose of primo at 20 mg a week to see if helped

Which it did , but maybe that small dose even lowered e2 to much after a while

I find I need a small dose of ai or primo every now and then to balance things out

So kinda in a pickle till get some new bloods done

I’m thinking

Just stick to my 122 test , 5 mg Cialis and the 25mg Dhea for a while see if balances things out

And run some more blood when I can

 

[Systemlord]

What were your before and after results of using Cialis which lowered your e2 levels

On TRT I don’t know for sure, but E2 was always very high alongside T.

My E2 was 18 when I had those labs showing an afternoon 104 ng/dL. Now my TT is 438 early morning and SHBG 37.

 

[madman]

It typically takes several months of chronic Cialis use to cause changes in E2 levels.

I'm the exception.

Test your estrogen before stopping the Cialis to confirm.

Testosterone:estradiol ratio changes associated with long-term tadalafil administration: a pilot study - PubMed

Sustained improvement in sexual function after 12 months of tadalafil administration is associated with increased T:E ratio mainly related to reduction of E levels. We hypothesize that androgen-estrogen cross-talk and possible inhibition of aromatase activity during chronic exposure to tadalafil...

pubmed.ncbi.nlm.nih.gov

2025 two days in and still talking out your ass I see!

Yes you clearly still have no clue!

Coming from the guy who never even read the full study!

Might want to sit and dwell on those take-home points!

Cialis Lowered Libido?

Hey there, to get right to it I took 20mg before an outing with a girl last weekend as some insurance. Oddly enough before taking the Cialis libido felt strong, and erections were normal, but about an hour after taking it I noticed my libido start to fade. This is resulted in inability to come...

www.excelmale.com

 

[madman]

Cialis crushes my estrogen which is why I can't take it. I have labs to confirm days after starting Cialis E2 plumits and the hot flashes from hell begin.

In this case the lower back pain would be from low estrogen, because estrogen is responsible for bone remodeling.

You have been a mess from the get-go on here!




* However, none of the PDE5 inhibitors are truly selective for the PDE5 receptor, and the majority of the negative effects are caused by cross-reactivity with other PDE isoenzymes.64

* Back pain and myalgias are caused by a high concentration of the PDE11 enzyme in skeletal muscle, which has a strong cross-reactivity with tadalafil.

​

https://journals.sagepub.com/doi/10.1177/0976500X221129008#bibr64-0976500X221129008

Synthetic PDE5 Inhibitors and Risk Factors Associated with Their Uses

PDE5 inhibitors are the primary line of treatment for ED patients.62 However, as PDE5 receptors are ubiquitous in the pulmonary vasculature, brain, lower urinary tract, and heart, PDE5 inhibitors are also an essential treatment option for pulmonary hypertension, neurological diseases, cardiomyopathy, and cancer.40, 41, 46, 47–49 ED has become a big concern, with recent predictions estimating that 320 million men will be affected by the disease by 2025.63 FDA-approved sildenafil, vardenafil, tadalafil, and avanafil, as well as non-FDA approved lodenafil, udenafil, and mirodenafil, are among the PDE5 inhibitors available (Figure 3).8, 64 However, none of the PDE5 inhibitors are truly selective for the PDE5 receptor, and the majority of the negative effects are caused by cross-reactivity with other PDE isoenzymes.64 The majority of these effects are dose-dependent.

Mild headaches, flushing, dyspepsia, altered color vision, back discomfort, myalgias, priapism, melanoma, hypotension and dizziness, rhinitis, nonarteritic anterior ischemic optic neuropathy (NAION), and hearing loss are some of the most prevalent side effects associated with the use of PDE5 inhibitors.64, 65 The presence of a high concentration of PDE6 enzyme in the rods and cones of the retina makes these cells a vulnerable target for PDE5 inhibitors causing altered color vision, particularly by sildenafil, which has a high affinity for blocking both PDE6 and PDE5. This effect has not been linked to any retinal structural or functional alterations.66, 67 Back pain and myalgias are caused by a high concentration of the PDE11 enzyme in skeletal muscle, which has a strong cross-reactivity with tadalafil. The FDA issued a warning on the possibility of hearing loss linked with PDE5I usage due to the pathophysiology that causes sensorineural hearing loss, which has been described in a few case studies.64 Additionally, using nitrates or nitroglycerin alongside PDE5 inhibitors increases the risk of hypotension. Vardenafil, tadalafil, and sildenafil have all been linked to longer QT intervals in ECGs, with vardenafil having the longest QT intervals, tadalafil having the shortest QT intervals, and sildenafil having intermediate QT intervals. Patients taking PDE5Is should wait at least 1–2 days following their last PDE5I dose before taking nitrates, according to the American College of Cardiology.63, 68 Erythromycin and HIV protease inhibitors are two examples of medications that interact with PDE5 inhibitors since they share the same metabolic pathway.68

 

[Scottmcty]

On TRT I don’t know for sure, but E2 was always very high alongside T.

My E2 was 18 when I had those labs showing an afternoon 104 ng/dL. Now my TT is 438 early morning and SHBG 37.

Your test levels are quite low ?

What yours test dose ?

 

[Scottmcty]

I’m going to have a break from Cialis for now and see how I feel

Can always bring it back in when feel like it

But like the way it helps blood pressure and prostate and other benefits which it brings

But guess haven a break now and then is a good thing to

 

[Systemlord]

Your test levels are quite low ?

I’m not on TRT anymore, these are my natural levels. I feel way better with these level than when on TRT and muscle size, recovery and strength are unchanged.

I only difference is I feel better off TRT and more energy. My FT is at the bottom end of the ranges.

 

[Scottmcty]

That’s good your off trt

I’ve been on trt to long now and at a age I don’t think my levels would ever return now

So trying to feel the best I can on trt

So trying to have a healthy life I can now on trt

My levels we to low naturally to have a decent lifestyle