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Lax industry regulation has allowed sales of supplements to thrive in the absence of verification of their purported benefits. Our primary objective was to systematically review all data published in the last two decades on testosterone boosters and determine their efficacy. Our outcome of interest was total testosterone increase versus placebo in four different populations: male athletes, men with late-onset hypogonadism infertile men, and healthy men.

CONCLUSIONS

Our extensive systematic review has concluded that most TBs fail to demonstrate their ability to increase sTT under RCT conditions. Notable exceptions were HMB and betaine, which can be considered effective TBs in male athletes.

 
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