Low GH, Normal T and LH/FSH

[buckleu]

Diagnosis: Hypogonadism
Male 42 years
Clinical features: Gynecomastia, truncal obesity, increased adipose tissue around waist and hips
Very low GH, normal FSH/LH/Prolactin/TSH, total T.

Any inputs would be highly appreciated.

 

[Systemlord]

Any inputs would be highly appreciated.

Total T doesn't define testosterone deficiency, the Free T is what truly matters. Experts believe Free T in the bottom 25% to be a sign of hypogonadism because the normal ranges have nothing to do with quality of life.

Experts also recommend against a hardline cut off to be considered for TRT due to men having different types of androgen receptors, differing sensitivity levels at the receptor to testosterone as well as the abilities for tissues to respond.

High SHBG can inflate the Total T, even though Free T is low.

Starvation, cutting can increase the SHBG by way of improved insulin sensitivity. The starvation can also decrease the Free T.

 

[buckleu]

Total T doesn't define testosterone deficiency, the Free T is what truly matters. Experts believe Free T in the bottom 25% to be a sign of hypogonadism because the normal ranges have nothing to do with quality of life.

Experts also recommend against a hardline cut off to be considered for TRT due to men having different types of androgen receptors, differing sensitivity levels at the receptor to testosterone as well as the abilities for tissues to respond.

High SHBG can inflate the Total T, even though Free T is low.

Starvation, cutting can increase the SHBG by way of improved insulin sensitivity. The starvation can also decrease the Free T.

SHBG is with in normal limits though.
IGF-1 is low normal.
Total T is wnl around 500-600 for the last many years

 

[buckleu]

Genome testing shows NR5A1 mutation. This is getting so confusing, the results do correlate with the phenotype, so it is not VUS.

 

[Systemlord]

SHBG is with in normal limits though.

Here’s some context. Go to LabCorp here in the US and get the same result and now you’re over the limit.

 

[Seagal]

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Diagnosis: Hypogonadism
Male 42 years
Clinical features: Gynecomastia, truncal obesity, increased adipose tissue around waist and hips
Very low GH, normal FSH/LH/Prolactin/TSH, total T.

Any inputs would be highly appreciated.

Do you have lab values for estradiol?
Are you doing any sports, physical exercises?
Sports and healthy nutrition can really make a difference.