Low estradiol on HRT

yuyi1980

New Member
Hello! Im new to the forum. Allow me to bring you up to speed. I was having all kinds of bad things happening from my low T which I had for years untreated as no Dr was willing to supplement it. I implemented many life style changes and supplementation to bring my test up, however, this never brought my numbers up. I finally decided to visit an anti-aging clinic and get some additional testing. I was then diagnosed hypogonodal with a 225 ng/dl. I have been on TRT for the past 2 years. Many improvements since, but it seems I have a few numbers to buffer that I can't get under control. I'm a fit guy, 33 years old, regularly workout, 220 with 15% body fat. I am currently treated with the following protocol.

.7ml of test cypionate 200ml/ml / week (split 2 Monday and Thursday)
1mg Anastrazole once per week (split twice a week)
Hcg 500ius twice a week.

I was originally instructed by my TRT dr to do IM injection once per week, however, AFTER doing much research I decided to go the sub-q method as if this is a permanent condition I was trying to prevent scar tissue. I have had great stable results with the sub-q route. I do 35 units of test twice per week and i stay within a very stable range of 1000 ng/dl to 1200. My issue now is that I'm not aromatize E2. I took the anastrazole at the beginning of the treatment and I realized after a couple of blood tests my estradiol was floored <3 to <5 (done at lab corp on Roche ECLIA Methodology 7.6 to 42.6 range.) Then after two blood tests I decided to discontinue the Anastrazole. Now, after 2 years my estradiol is still <5 with. I requested the Dr. to check for estrogen and it is slightly elevated 289 ng/dl. Im concerned about my estradiol levels being floored all year-around. Is it to blame my sub-q administration for poor aromatization?

I just switched three weeks ago to IM to see if I can boost my estradiol level. I am 33 years old and I don't have no morning erections which I believe is somehow related to my estradiol. Im more concerned with other more permanent side effects such as bone density and osteoporosis, but even though it says to be low I feel most of the sides of high estradiol.

* Depression
* No erections while sleeping (i.e. "night wood" or "morning wood")
* Anxiety
* Water Retention
* Increased Blood Pressure
* Decreased Libido
* When penis is limp, it doesn't hang low (it seems to try to crawl back up) At times this could be so retracted it can be painful.
* Trouble sleeping at night - waking up multiple times per night
* Lack of Libido
* Crying while watching TV shows/movies
* Easier to get angry (think PMS)

Anyone here have had a similar issue? My dr has no idea why I'm not aromatizing. And why my estrogen levels are elevated while my E2 is negative. I went to see a second Dr for a second opinion and he strongly advised me to get back to the Anastrozole, he said this was nothing else than estrogen moving due to injections and fluctuations. I was not too comfortable getting back on the Anastrazole as if these tests are accurate, this will further suicide more estrogen in my body. Instead I started taking DIM which I incorporated into my supplementation out of the fear of not bringing any estrogen support to my protocol.

Your thoughts will be greatly appreciated
 
When your e2 crashes it may take a few weeks to return to a normal level. I also take 200mg of Test cyp a week (spit into 2 100mg sub-q injections) and for me 0.25mg of Anastrozol twice weekly (or half as much as you were taking) is almost too much.

I would also go to the nearest Labcorp and do my own blood work. Get the hormone panel for females (its for men, too) as it is like $50.
 
Thanks man! I will do that. I really need to get this straighten out. I honestly dont think the lab test is accurate. I have been 2 years without an IA with my test in the 1200 and this E2 seems not to move up.
 

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