Jatenzo, an Oral Testosterone Replacement Therapy

[Systemlord]

Oral is good, but twice a day and its effectiveness varies with your diet. It's great news, but I'm wondering how well it will work in practice.

I consume a spoonful of peanut butter with my Jatenzo, the peanut butter is high in fats and is how Jatenzo is absorbed -> through fatty acids. I actually put it to the test and only had a spoonful of peanut butter before lab testing and got excellent numbers.

My Experience On Jatenzo (Oral TRT) Log

I wanted to start a thread detailing my personal experience with Jatenzo (oral TRT) which is remarkable in how quickly it has shown results when compared with injections. The first week on Jatenzo was very pleasant unlike my experience after dosing changes on injections, all with minimal swings...

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[madman]

I consume a spoonful of peanut butter with my Jatenzo, the peanut butter is high in fats and is how Jatenzo is absorbed -> through fatty acids. I actually put it to the test and only had a spoonful of peanut butter before lab testing and got excellent numbers.

My Experience On Jatenzo (Oral TRT) Log

I wanted to start a thread detailing my personal experience with Jatenzo (oral TRT) which is remarkable in how quickly it has shown results when compared with injections. The first week on Jatenzo was very pleasant unlike my experience after dosing changes on injections, all with minimal swings...

www.excelmale.com

Keep in mind that the amount of fat you are taking in will have an impact on the bioavailability.

30 g fat would be more effective than 15 g.

You would most likely fair better taking in more PB/serving (4 tbsp).

You are taking in <15 g.....if it works for you then stick with it!


Peanut butter: 1 tbsp (16 g) = 7.98 g fat
Peanut oil: 1 tbsp (14 g) =14 g fat
Olive oil: 1 tbsp (14 g) = 14 g fat
Avacado oil: 1 tbsp (14 g) = 14 g fat
Butter: 1 tbsp (14.2 g) = 11.5 g fat
Ghee: 1 tbsp (14 g) = 14 g fat
Coconut oil: 1 tbsp (13.6 g) = 13.5 g fat
Cod liver oil: 1 tbsp (13.6 g) = 13.6 g fat
Salmon oil: 1 tbsp (13.6 g) = 13.6 g fat
Egg yolk: 1 large (17 g) = 4.5 g fat


*When JATENZO was dosed with different breakfasts containing various amounts of fat, the bioavailability with the 30 g fat, 45 g fat, and high-calorie high-fat breakfasts was comparable, but there was a food effect with the 15 g fat breakfast compared to the 30 g fat breakfast

*The 15 g fat breakfast had a 25% decrease in testosterone exposure compared to the 30 g fat breakfast

 

[Nelson Vergel]

I consume a spoonful of peanut butter with my Jatenzo, the peanut butter is high in fats and is how Jatenzo is absorbed -> through fatty acids. I actually put it to the test and only had a spoonful of peanut butter before lab testing and got excellent numbers.

What is your Jatenzo dose and how high did your total testosterone get? Thanks

 

[Systemlord]

What is your Jatenzo dose and how high did your total testosterone get? Thanks

In the beginning Jatenzo at 158mg (twice daily) got my Total T to 469 and felt amazing, but after about 2 moths I noticed I started feeling physically weaker, found my levels had dropped to 276.

My doctor increased the dosage to 198mg which got me 397, felt good only some of the time. Strangely my A1C continued to drop even at 276 and started 237mg a week ago and my energy is higher.

The recommended starting dosage for Jatenzo is 237mg twice daily.

My A1C has dropped 4% in 3 months on Jatenzo!

 

[Nelson Vergel]

Jatenzo: Promising results with oral testosterone undecanoate

In this video, Ronald Swerdloff, MD, discusses the background and findings of the study, “Two-Year Administration Data of an Oral Testosterone Undecanoate (TU) Formulation in Hypogonadal Men,” presented recently at the 2021 Sexual Medicine Society of North America Fall Scientific Meeting...

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[Nelson Vergel]

PATIENT SATISFACTION AFTER SWITCHING TO ORAL TESTOSTERONE UNDECANOATE IN MEN CURRENTLY RECEIVING TESTOSTERONE THERAPY: AN OPEN-LABEL SINGLE-CENTER PHASE IV CLINICAL TRIAL​

 

[Nelson Vergel]

LINEAR RELATIONSHIP BETWEEN THE TIME OF DOSING AND 24-HR (Cavg) OF TT IN MEN TREATED WITH JATENZO®

LINEAR RELATIONSHIP BETWEEN THE TIME OF DOSING AND 24-HOUR AVERAGE CONCENTRATION OF TOTAL TESTOSTERONE IN MEN TREATED WITH AN ORAL TESTOSTERONE UNDECANOATE CAPSULE (JATENZO®) Ronald Swerdloff, Jason Kovac, Christina Wang, Marc Gittelman, B. Woun Seo, Jay Newmark, Nestor Rohowsky, and Robert...

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[Nelson Vergel]

A new one competing with Jatenzo.

Tlando: Another Oral Testosterone Undecanoate OK'd for Hypogonadism

FDA approval of Tlando follows in the footsteps of Jatenzo The recommended dosage is 225 mg orally twice daily with food. It does not require dose titration. "We believe Tlando's oral formulation and convenient dosing, which requires no titration, differentiates it from other treatment...

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[Systemlord]

PATIENT SATISFACTION AFTER SWITCHING TO ORAL TESTOSTERONE UNDECANOATE IN MEN CURRENTLY RECEIVING TESTOSTERONE THERAPY: AN OPEN-LABEL SINGLE-CENTER PHASE IV CLINICAL TRIAL​

T levels increased from a baseline mean of 201 ng/dL to 686 ng/dL at 1 month and 527 ng/dL at 3 months.

This is pretty much what I've seen in my own testing and is detailed in my Jatenzo thread. It seems even though steady states are achieved at seven days, your body is still working things out beyond that point.

 

[Nelson Vergel]

ORAL TESTOSTERONE VERSUS TOPICAL TESTOSTERONE: LARGER DECREASES IN HDL

CHANGES IN METABOLIC PARAMETERS AND BONE MARKERS WITH ORAL VERSUS TOPICAL TESTOSTERONE (2022) Fiona Yuen, Ronald S Swerdloff, Robert Dudley, and Christina Wang The Lundquist Institute at Harbor-UCLA Medical Center, Torrance, CA; Clarus Therapeutics, Northbrook, IL Background: Oral testosterone...

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