Is HCG safe for long term use

[Vince]

HCG shuts down HPTA and may not generate enough intratesticular testosterone (ITT).

 

[Saxon]

It would be great if u can give me some info regarding this as i can convince my friend about it.

It would be great if the doctor could provide some medical literature backing up her view.

 

[tersec]

Would 250iu every 3.5 days be to low a dose?

 

[Vince]

Would 250iu every 3.5 days be to low a dose?

Some members on trt, use as little as 100 IU of HCG once a week. Others members go up to 500 IU every other day. I use 500 IU twice a week.

 

[Jayyy]

I've been using 250iu every 4 days and it has been keeping the boys full, I did 250iu eod up until I started the lower dose and I don't see any drastic difference in testicle size.

Nice, Its little different than usuall dosage. Did specialist recommended this dosage or your doing it by yourself. How long have u been using HCG? Any variations in PSA levels?

 

[Jayyy]

When I first originally started using ed meds. I did get heartburn and a very sore back, overtime all the bad side effects slowly went away.

Ya looks like i have to start low dosage. A guy in this forum told me to start with 2.5mg cialis everyday. Also, Do u think it will help u in muscle gain?

 

[Jayyy]

Basically yes. However , it can be used to increase your testosterone levels instead of TRT. I mean fertility might be a reason but not always. Some men don’t like TRT because it causes testicular atrophy hence they choose HCG monotherapy but the doses are much higher than when HCG is combined with TRT. It’s very expensive compared to Cypionate for example and seems to bring inferior subjective results. But again, it’s a matter of preference and it’s an option for TRT

Agree with you. Not only its expensive but high HCG dosage might desensitize the leydig cells or increase the PSA levels. High dosages are only good for short term like 6 months when ur expecting to increase sperm count after TRT therapy but again this is just my assumption.

 

[Jayyy]

Some members on trt, use as little as 100 IU of HCG once a week. Others members go up to 500 IU every other day. I use 500 IU twice a week.

How do they adjust HCG dosage? Is it by checking testicular size or sperm count or just an educated guess. Or is there any blood test which we can monitor to adjust the HCG dosage?

 

[Jayyy]

It would be great if the doctor could provide some medical literature backing up her view.

Here is some materials but its studied in women.
Cancer Risk After Exposure to Treatments for Ovulation Induction
Cancer Risk in Women Treated with Fertility Drugs According to Parity Status—A Registry-based Cohort Study

 

[Vince]

How do they adjust HCG dosage? Is it by checking testicular size or sperm count or just an educated guess. Or is there any blood test which we can monitor to adjust the HCG dosage?

You check your testicles, if it's not working, you just increase your dose. If you're using it to remain fertile, then of course you need a sperm count.

 

[DragonBits]

Hi Folks,
I am thinking at start TRT + HCG and would like to know what is the long term side effects of using HCG. I know few people use HCG only when they trying to conceive but what if i keep using HCG for like lets say 5 years. Does it cause any problems? The reason for not trying TRT alone is that I am worried what if my sperm count do not return to normal after i quit TRT as i already have an issue with my testicles and have few sperm count like 2 millions

What you are asking for is anecdotal information, which is less than useful.

Men come to TRT because they are deficient in testosterone. Why are they deficient varies all over the place, from having only 1 testicle, testicle damage, old age, viral diseases, naturally low T, previsions steroid abuse, genetic problems, etc, etc.

So their response to HCG will also vary all over the place. If someone has a problem with their testicles, perhaps they don't respond to HCG in the same way as someone that is just low on total T?

HCG is NOT LH.

"The shorter half-life of LH is physiologically important, as it allows for the production of LH pulses. The longer half-life of hCG and its greater receptor binding affinity make it more biologically active than hLH. The longer half-life of hCG and its greater receptor binding affinity make it more biologically active than hLH."

Luteinizing hormone and human chorionic gonadotropin: Origins of difference - ScienceDirect

It' often said we have many LH receptors in many places, not mentioned in this article from Peak T is the prostate also has LH receptors.

If you read this article from peak T about other LH receptors, you see the following

"Interestingly enough, what has been confirmed in men, women and animals is that high luteinizing hormone is hard on memory. "

"So clearly HCG and LH can increase cortisol through activity on the adrenal gland. "

The article speculates that if high LH definitively causes these problems, will low LH cause the opposite problem? No one knows. And what is the opposite of hard on memory?

One thing that concerns me it the greater binding affinity of HCG Vs lh.

LH (Luteinizing Hormone) Receptors

If you are concerned about fertility, then why not freeze your sperm? Sure it cost money, but so does HCG. And getting a supply of good sperm and freezing it seems like a more sure thing.

My bottom line, no research has been done on long term use of HCG in men. a lot of men on places like Excelmale use it, have no problems and like it, many don't use it and don't like it. You won't get a definitive answer either way.

 

[HealthMan]

For me the lowest amount of HCG that work to avoid atrophy is 400IU 2x a week. Any lower than that and i experience some levels of testicular atrophy.

 

[Jayyy]

What you are asking for is anecdotal information, which is less than useful.

Men come to TRT because they are deficient in testosterone. Why are they deficient varies all over the place, from having only 1 testicle, testicle damage, old age, viral diseases, naturally low T, previsions steroid abuse, genetic problems, etc, etc.

So their response to HCG will also vary all over the place. If someone has a problem with their testicles, perhaps they don't respond to HCG in the same way as someone that is just low on total T?

HCG is NOT LH.

"The shorter half-life of LH is physiologically important, as it allows for the production of LH pulses. The longer half-life of hCG and its greater receptor binding affinity make it more biologically active than hLH. The longer half-life of hCG and its greater receptor binding affinity make it more biologically active than hLH."

Luteinizing hormone and human chorionic gonadotropin: Origins of difference - ScienceDirect

It' often said we have many LH receptors in many places, not mentioned in this article from Peak T is the prostate also has LH receptors.

If you read this article from peak T about other LH receptors, you see the following

"Interestingly enough, what has been confirmed in men, women and animals is that high luteinizing hormone is hard on memory. "

"So clearly HCG and LH can increase cortisol through activity on the adrenal gland. "

The article speculates that if high LH definitively causes these problems, will low LH cause the opposite problem? No one knows. And what is the opposite of hard on memory?

One thing that concerns me it the greater binding affinity of HCG Vs lh.

LH (Luteinizing Hormone) Receptors

If you are concerned about fertility, then why not freeze your sperm? Sure it cost money, but so does HCG. And getting a supply of good sperm and freezing it seems like a more sure thing.

My bottom line, no research has been done on long term use of HCG in men. a lot of men on places like Excelmale use it, have no problems and like it, many don't use it and don't like it. You won't get a definitive answer either way.

Thanks Dragon,
Regarding freezing the sperm, i will definitely do it. This is extra precaution. I just came to know that i have vericocele on leftside testicles. Hopefully repairing it will bring back my spermcount. If i had normal sperm count to begin with then i would'nt mind doing only test but since i have low sperm count, i though ill do both hcg and test. Looks like HCG low dose might be safer. Thanks

 

[Wean]

Thanks Dragon,
Regarding freezing the sperm, i will definitely do it. This is extra precaution. I just came to know that i have vericocele on leftside testicles. Hopefully repairing it will bring back my spermcount. If i had normal sperm count to begin with then i would'nt mind doing only test but since i have low sperm count, i though ill do both hcg and test. Looks like HCG low dose might be safer. Thanks

I got my varicocele fixed novimprovment in t levels or sperm just freeze what u can

 

[Jayyy]

I got my varicocele fixed novimprovment in t levels or sperm just freeze what u can

Thanks for reply. Sure i will freeze.

 

[Harley]

What you are asking for is anecdotal information, which is less than useful.

Men come to TRT because they are deficient in testosterone. Why are they deficient varies all over the place, from having only 1 testicle, testicle damage, old age, viral diseases, naturally low T, previsions steroid abuse, genetic problems, etc, etc.

So their response to HCG will also vary all over the place. If someone has a problem with their testicles, perhaps they don't respond to HCG in the same way as someone that is just low on total T?

HCG is NOT LH.

"The shorter half-life of LH is physiologically important, as it allows for the production of LH pulses. The longer half-life of hCG and its greater receptor binding affinity make it more biologically active than hLH. The longer half-life of hCG and its greater receptor binding affinity make it more biologically active than hLH."

Luteinizing hormone and human chorionic gonadotropin: Origins of difference - ScienceDirect

It' often said we have many LH receptors in many places, not mentioned in this article from Peak T is the prostate also has LH receptors.

If you read this article from peak T about other LH receptors, you see the following

"Interestingly enough, what has been confirmed in men, women and animals is that high luteinizing hormone is hard on memory. "

"So clearly HCG and LH can increase cortisol through activity on the adrenal gland. "

The article speculates that if high LH definitively causes these problems, will low LH cause the opposite problem? No one knows. And what is the opposite of hard on memory?

One thing that concerns me it the greater binding affinity of HCG Vs lh.

LH (Luteinizing Hormone) Receptors

If you are concerned about fertility, then why not freeze your sperm? Sure it cost money, but so does HCG. And getting a supply of good sperm and freezing it seems like a more sure thing.

My bottom line, no research has been done on long term use of HCG in men. a lot of men on places like Excelmale use it, have no problems and like it, many don't use it and don't like it. You won't get a definitive answer either way.

You say no research has been done but there are countries like Poland where the use of Testosterone is banned as it hurts fertility and so they use HCG .
I have seen a lecture by a polish endocrinologist who has been using HCG for many years on his patients with great success.

 

[Mr S]

My urologist offered me that as a choice: Clomid, HCG, Cypionate, or TRT + HCG. He didn’t see HCG monotherapy as a problem at all. It’s very expensive though but it was totally up to me.

 

[LowTSwiss]

Hello community, I have been using HCG for approximately 3 years now, and since 2 years as monotherapy (at 2500 IU twice a week). Body weight 225 lbs. First started TRT 5 years ago at age 38 and went without HCG for the first 2 years.

Current total testosterone level is at 20 nmol/L and free testosterone at 72 pgmol/L (most recent lab values from last week).
Now I have a concerning lab value for the first time: my PSA suddenly jumped to 2.8 µg/L, and I have always had values around 0.7 µg/L so far (the least measurement at 0.7 µg/L dates back to September 2019). I know that I have benign prostate hyperplasia, but this jump in PSA is concerning to me. I was referred to my urologist for further check-up.

Is there any data available regarding long-term effects of HCG (mono)therapy on PSA levels? I have not found anything in the literature so far.
Thank you!

 

[Nelson Vergel]

Hey LowTSwiss
Welcome to our community.
You may want to read this

Seven causes of a high PSA that are not cancer

The prostate-specific antigen test is a blood test that measures levels of a protein the prostate gland produces. Men with prostate cancer usually have elevated levels of this protein, but heightened levels do not always mean cancer. Other health conditions may also cause prostate-specific...

www.excelmale.com

 

[LowTSwiss]

Hey LowTSwiss
Welcome to our community.
You may want to read this

Seven causes of a high PSA that are not cancer

The prostate-specific antigen test is a blood test that measures levels of a protein the prostate gland produces. Men with prostate cancer usually have elevated levels of this protein, but heightened levels do not always mean cancer. Other health conditions may also cause prostate-specific...

www.excelmale.com

Hi Nelson,
thank you for your quick response and the link!

I will have another lab test beginning of September. If the value is still that high or higher, further investigations (an MRI and possibly a biopsy) will be conducted.

Prostatitis is unlikely, there is no pain at all, but who knows. I have prostate hyperplasia already at age 43 (approx. 40 ml volume, which is quite a lot).

I´ll introduce myself a bit in the introduction section later, this forum here is great - thank you so much for creating it!