Inverse Relationship between HGH and SHBG

[Wild_Man]

In Hertoghe’s course on GH, he states raising GH lowers SHBG and increases conversion to DHT

That’s exactly the type of info I’m looking for! Fuck yeah, thank you for mentioning that. I’ll look into Hertoghe but what is the course called? Can you be more specific or post a link? Thanks

 

[Deleted member 43589]

The two results from 2022 and 2023 were both taken during the summer when I’m outside more and eating less so maybe that was why. But I eat a lot of carbs these days. Basically, the equivalent of an entire grocery-store baguette per day. But I’ll monitor my triglyceride level in the future to see if it drops lower than where it is now (62). Thanks for bringing this to my attention. I didn’t know of this relationship.

@Wild_Man, a whole baquette is only 71g Carbs total. That is just barely enough to keep you out of ketosis. Today is my lower carb day (weekends) and I consumed 30% carbs.....total - 343g. My higher carb day is about 49% (training days) - total 612g.

 

[Belekas]

@Wild_Man, a whole baquette is only 71g Carbs total. That is just barely enough to keep you out of ketosis.

Exactly. Actually I was a bit surprised that nobody asked exactly whats he eating and in what amounts, etc and even more context. If I'll be running on 71g carbs/day I would be flat out zombie with no power and feeling like a complete shadow of myself. Context is all that matters. I probably have around 70-100g carbs for breakfast just to start the day and mind you I'm a light-weight right now. When I was too restrictive with my food a couple years ago prior starting TRT my SHBG also was higher and after adding them back in it went lower but not by much fwiw. Usually what I find with people who are training that they are underfed and overworked and giving them more food and more rest usually works wonders even though some don't want to do it and prefer to go round and round in their old ways.

 

[Deleted member 43589]

Exactly. Actually I was a bit surprised that nobody asked exactly whats he eating and in what amounts. If I'll be running on 71g carbs/day I would be flat out zombie with no power and feeling like a complete shadow of myself. Context is all that matters. I probably have around 70-100g carbs for breakfast just to start the day and mind you I'm a light-weight right now. When I was too restrictive with my food a couple years ago prior starting TRT my SHBG also was higher and after adding them back in it went lower but not by much fwiw. Usually what I find with people who are training that they are underfed and overworked and giving them more food and more rest usually works wonders even though some don't want to do it and prefer to go round and round in their old ways.

Exactly. 71g of carbs and I would run out of gas on the way to work I actually have my 1st meal at 4:30am and consume 85g of carbs in my big bowl of Honey Bunches of Oats/Almonds cereal. My 2nd meal is 250g of carbs just to make it to the gym.

These low fat diets are not so healthy. My old friend from South Africa was a huge fitness buff, ran marathons, lifted weights but he was on a low fat diet supposedly to keep healthy and died of a heart attack at 59.

Fats are needed for energy, temperature regulation and protection of internal organs. Fats are also important for hormone production and regulation. Testosterone is derived via a “sterane ring structure” where cholesterol is converted into pregnenolone, then into either dihydroepiandosterone (DHEA) or progesterone, then into either androstenedione or androstenediol, and finally into testosterone.
Here is a very good paper that explains the importance of nutritional status to the GH/IFG-1 axis.

Regulation of GH and GH Signaling by Nutrients

Growth hormone (GH) and insulin-like growth factor-1 (IGF-I) are pleiotropic hormones with important roles in lifespan. They promote growth, anabolic actions, and body maintenance, and in conditions of energy deprivation, favor catabolic feedback mechanisms ...

www.ncbi.nlm.nih.gov

8. Conclusions​

As described above, GH/IGF-I axis homeostasis is strictly connected to all the diet components. Nutrients are plain modifiers of the GH/IGF-I axis. Identifying a diet with a healthy balanced mixture of nutrients also healthy for the mediated effects on GH and IGF-I is complicated by the manifold composition of energy regimens and synergistic effects of nutrients on each other and hormonal axes. Furthermore, food processes, both in experimental animal models and in human life, including home cooking and industrial processing are neglected factors because of difficulties in analyzing them, mainly in humans. Calories and nutrients modulate the pathways that have evolved to switch from growth and reproduction toward survival and maintenance during CR and famine [378,379]. The imbalance of one or more macro- and micronutrients could affect the short- and long-term GH and IGF-I secretion and actions, with repercussions on growth, anabolism, and nutrients sensing [380]. All the evidence discussed in this review derives from models aiming to dissect the effect of single nutrients on GH and IGF-I. However, nutritional deficiencies due to peculiar food restrictions could hide multiple deficiencies or excesses, leading to debatable results. Recently, advances in nutritional geometry have helped to study nutrition as a framework to begin deciphering how nutrients interact and orchestrate mechanisms linked to healthy aging and lifespan [381,382]. Expanding this approach to hormonal regulation, like that of the GH/IGF-I axis could add new depth and open perspectives in nutrition management, prevention, and treatment of GH/IGF-I deficiency or excess at different time points of life.

 

[Wild_Man]

@Wild_Man, a whole baquette is only 71g Carbs total. That is just barely enough to keep you out of ketosis. Today is my lower carb day (weekends) and I consumed 30% carbs.....total - 343g. My higher carb day is about 49% (training days) - total 612g.

@BigTex and @Belekas I just checked the nutrition block on the bread I buy and it has 180g carbs total in it. And I also eat fruit so I'm above at least 200g everyday.

 

[Keepfit1]

That’s exactly the type of info I’m looking for! Fuck yeah, thank you for mentioning that. I’ll look into Hertoghe but what is the course called? Can you be more specific or post a link? Thanks

It’s one of many courses he sell meant to be for docs, he also has new book out on GH

 

[apsjiml]

I have posted in the past about my severely low IGF-1 levels. Recently, I came across an interesting relationship in my own labs and out of interest, I found it backed up in medical literature. Wondering if anyone else has had a similar experience or knows anything that relates to this?

I have had IGF-1 tested many times and I have a severe deficiency of it. And at the same time my SHBG is very high. So I got looking into it and found a good amount of literature on the inverse relationship between HGH and SHBG. Apparently, HGH rises during male puberty and it lowers your SHBG level. This explains why, during puberty boys both grow in height and develop masculine features. The HGH makes them taller and the lowering of SHBG increases their free testosterone. I, however, am lacking this.

This is an example of a study that demonstrates this relationship.

High serum sex hormone-binding globulin (SHBG) and low serum non-SHBG-bound testosterone in boys with idiopathic hypopituitarism: effect of recombinant human growth hormone treatment - PubMed

We measured serum sex hormone-binding globulin (SHBG), total testosterone (T), non-SHBG-bound T, albumin-bound T, free T, and SHBG-bound T in 19 prepubertal boys with hypopituitarism. Serum SHBG decreased with age with a slope similar to that in 91 normal prepubertal boys at higher level, and...

pubmed.ncbi.nlm.nih.gov

HgH does lower shbg and I failed the ITT stim test for growth hormone however gh did not low my shbg but it would depend on the person and the cause.

 

[Belekas]

@BigTex and @Belekas I just checked the nutrition block on the bread I buy and it has 180g carbs total in it. And I also eat fruit so I'm above at least 200g everyday.

Def should try to ditch the bread and incorporate white potatoes or something like white rice, depending which one you digest better. Potatoes are more beneficial as they are high in potassium, fiber, etc, which is crucial for a lot of things and IMO the RDA is just a minimum. I personally love bread and always have eaten Sourdough bread and fresh if I can get as it digest the best, but its expensive. So I have removed bread copletely from my diet and have it just once a week or so during my cheat-day. Removed diary products as well. I've been diabbling with my genetics and found out that my genes suspectably are not the best to tolerate lactose, gluten and sugar. Not that I noticed too much. Will see what happens though. But yeah 200g carbs/day sounds ok just would like to see them from a healthier source. Fruit/berries are OK. Have myself blueberries pretty much every day, some dried plums, grapes and some melon. Oh and some bananas, yeah as they high in potassium as well. Watermelon is great as well. Coconut water. Etc. Just a few tips to see if they improve the way you feel and your symptoms if you have any atm