How to Treat Acne Caused by Testosterone Therapy

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Testosterone replacement therapy (TRT) is the prescribed treatment for men with low testosterone levels. It has become a widespread treatment--as many as 11 million men were undergoing TRT in 2013, a number that has grown significantly since.


However, as with any treatment, there are a few adverse side effects of TRT. Thankfully, most are fairly minor. One of the most common is one you probably thought you wouldn't have to deal with once you passed your teenaged years. That's right, I'm talking about acne!

Testosterone and Acne: The Link

How does testosterone replacement therapy lead to the formation of zits? It may seem like a bit of a stretch, but it all comes down to one simple hormone: dihydrotestosterone, or DHT.

DHT is a hormone that is produced by your body from testosterone. It's actually five times more potent than testosterone, and it plays a vital role in your sexual development and health. When young men are going through puberty, their bodies produce a lot of DHT in order to encourage the growth of their reproductive organs.

But did you know that DHT also causes your body to produce more skin oils? This increase in skin oils causes the skin to become more oily, which means more oil may get into your pores. When the oil mixes with dead skin cells, the result is that thick white sebum that spurts out of your pimples every time you pop them. Oily skin is one of the primary causes of acne.

So, is it any surprise that TRT increases your risk of acne? TRT is basically flooding your body with testosterone, which is then converted to DHT. The potent hormone increases the production of skin oil, which in turn increases your risk of developing pimples. The P. acne bacteria already lives on your skin, speeding up the rate at which your skin cells die off. Mix the dead skin cells with the increase in skin oil, and you have a TRT-fueled recipe for acne.

If you've been on TRT for a few weeks and are noticing more pimples breaking out on your face, back, and chest (yes, the zits aren't confined to your face), it's a sign your body is turning the testosterone into DHT. While this is a good thing for your overall health, it may affect your appearance. Thankfully, there's plenty you can do to deal with the problem!

How to Deal With TRT-related Acne

Want to get rid of pimples or prevent your TRT treatment from causing an outbreak? Here are a few things you can try:

- Use Accutane -- Accutane, or isotretinoin, is one of the most potent prescription treatments to cure acne. It's usually used to treat cystic acne, which is a much more serious form of acne that is likely to cause scarring. The treatment is effective in up to 85% of cases. Taking 40 mg of Accutane every day for a week can do wonders for your acne. However, be aware that the medication does come with side effects, and it may lower testosterone levels. Consult your physician before mixing TRT and Accutane.

- Use Sporanox -- Sporanox, or itrconazole, is another useful medication to try as a means of curing your acne. It is an anti-fungal drug that may be able to kill off the P. acne bacteria that is increasing your skin cell turnover rate, thereby increasing your risk of clogged pores. Once again, check with your doctor before mixing TRT and Sporanox.

- Try Vitamin B5 -- Vitamin B5, or pantothenic acid, is needed by your body in order to produce CoEnzyme A (CoA). This enzyme helps to oxidize (burn) fatty acids, particularly in your skin. If you don't have enough of this CoA, your body won't be able to eliminate the fatty acids produced by an increase in DHT, so the skin oil will increase and lead to acne. By taking Vitamin B5, you give your body what it needs to keep the fatty acid production under control.

- Try anti-acne soap -- There are a number of anti-acne soaps available at every pharmacy and supermarket in the country. These soaps are often made with Benzoyl Peroxide or Salicylic acid, two highly effective anti-acne treatments. Ideally, you should shower after a heavy workout, and use the soap to wash your face and any body parts where there is an acne breakout. Topix Benzoyl Peroxide is a body wash worth trying.

- Try zinc -- Zinc is one of the most important minerals for a healthy body. It plays a vital role in many important internal functions, not the least of which is your body's immunity to disease. But how can it help to protect against acne? Zinc ensures that your bloodstream carries sufficient Vitamin A to your skin, and it helps to regulate the cellular apoptosis (death) of your skin cells. By ensuring that your skin cells die at a healthy rate, zinc essentially prevents the buildup of dead skin cells that soaks up skin oil to clog your pores.

- Get out -- Your body NEEDS sunlight in order to produce Vitamin D, one of the vitamins that play a role in fatty acid oxidation. However, be warned: too much sunlight can dry out your skin, causing it to produce even more oil. No more than 30 minutes of sunlight per day is needed to encourage healthy Vitamin D production.

If your acne is the result of the TRT, you may want to consider reducing the dose of testosterone. This can reduce the amount of DHT produced in your body, preventing acne. However, this is something you should discuss with your doctor. You can also discuss other useful treatments for dealing with TRT-related acne.

Compounded acne formulations from Empower Pharmacy:Dermatology | Empower Pharmacy


Top 6 FDA-Approved Acne Treatments You Should Try - ExcelMale

Acne and Testosterone


 
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Im now using Head & Shoulders with 1% Pyrithione Zinc as a full body wash after reading about Zinc and many others using H&S for the treatment of stubborn bacne. I'm only two days in but will update.
 
Im now using Head & Shoulders with 1% Pyrithione Zinc as a full body wash after reading about Zinc and many others using H&S for the treatment of stubborn bacne. I'm only two days in but will update.

Does this work? Looking for body wash to help with slight acne
 
I had better luck with Selsun Blue and the selenium ingredient in it. I think that and getting me Estrogens undercontrol has done the trick to where I'm largely under control now with just minor nuisances.
 
Does this work? Looking for body wash to help with slight acne
You can consider Nizoral shampoo as well. Problem is, if you live in the States the strongest concentration, 2%, is only available by prescription. You can buy a 1% otc. I use the 2% here in Canada and it does a good job.
 
I've found that my acne flare ups are tied to consumption of dairy. No diary, no acne. If I consume dairy, three or four days later I'll have an acne flare up. I'm not the only one to make this connection. Here's an interview with a dermatologist on the connection.
 
This is the most popular antibiotic for acne. Look at how many more benefits it may have!

Source: Minocycline: far beyond an antibiotic

"These findings specifically concern to minocycline as it has recently been found to have multiple non-antibiotic biological effects that are beneficial in experimental models of various diseases with an inflammatory basis, including dermatitis, periodontitis, atherosclerosis and autoimmune disorders such as rheumatoid arthritis and inflammatory bowel disease. Of note, minocycline has also emerged as the most effective tetracycline derivative at providing neuroprotection. This effect has been confirmed in experimental models of ischaemia, traumatic brain injury and neuropathic pain, and of several neurodegenerative conditions including Parkinson's disease, Huntington's disease, amyotrophic lateral sclerosis, Alzheimer's disease, multiple sclerosis and spinal cord injury. Moreover, other pre-clinical studies have shown its ability to inhibit malignant cell growth and activation and replication of human immunodeficiency virus, and to prevent bone resorption. Considering the above-mentioned findings, this review will cover the most important topics in the pharmacology of minocycline to date, supporting its evaluation as a new therapeutic approach for many of the diseases described herein"
 
J Clin Aesthet Dermatol. 2018 Sep;11(9):37-41. Epub 2018 Sep 1.
Continuous Dark Chocolate Consumption Affects Human Facial Skin Surface by Stimulating Corneocyte Desquamation and Promoting Bacterial Colonization.


Abstract
Background: Nutrition can influence skin health. Dark chocolate possesses health promoting properties, but its consumption can exacerbate acne vulgaris in young people. Objective: We evaluated effects of continuous dark chocolate intake on morphological characteristics of the residual skin surface components (RSSCs) collected from the facial skin of young and middle-aged men. Methods: RSSC samples were taken from 17 young and 16 middle-aged men before and after a four-week consumption period of dark chocolate (10g per day). Lipid droplet size, corneocyte desquamation, and microbial presence levels were measured in the collected RSSC. The project was registered as ISRCTN89815519 in the ISRCTN registry (ISRCTN Registry). Results: Chocolate consumption caused a significant increase in corneocyte desquamation only in the group of young men, whereas Gram-positive microorganism presence significantly increased in both the young and middle-aged men, though this effect was noticeably stronger in the young men. Conclusion: Dark chocolate consumption appears to affect the facial skin of young men by enhancing corneocyte desquamation and promoting bacterial colonization of the RSSC. These changes might potentially contribute to acne development.
KEYWORDS:
Acne vulgaris; corneocyte desquamation; dietary chocolate; facial epidermis; microbial presence
 
 
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