Hormones and Stroke: An update on treatment and risk

madman · Feb 21, 2024

Introduction (00:00)
Dr. Matthew Nudy (03:57)
Prof. Dominique Cadilhac (26:34)
Q&A (54:24)

04:01 Hormonal effects on stroke risk include factors specific to women and may be hormonally mediated.
08:01 Risk factors for cardiovascular disease include diabetes, hypertension, obesity, tobacco use, high cholesterol, age, family history, and more.
10:15 Premature menopause before the age of 42 is associated with nearly double the risk of stroke.
12:06 Women experiencing moderate to severe menopausal symptoms may have an increased risk of stroke.
13:53 Clinical trials like the WHI showed an increased risk of stroke with hormone therapy, particularly with oral estrogen.
19:01 ️ The timing hypothesis suggests that the effects of estrogen on stroke risk may vary depending on age or time since menopause.
23:51 Transdermal estrogen may be safer regarding stroke risk compared to oral estrogen, but more research, especially randomized clinical trials, is needed.
- 49:41 Movement-based mindfulness intervention is designed to reduce stress levels, blood pressure, and potentially influence blood glucose and lipid levels, benefiting stroke recovery.
- 50:24 Digital health interventions, including mobile apps, can personalize strategies for risk factor reduction and chronic disease management, improving lifestyle behaviors for stroke prevention.
- 51:35 The Stroke Riskometer app endorsed by the World Stroke Organization aids in primary prevention by assessing modifiable risk factors and encouraging users to seek preventative measures.
- 52:19 Wearable technology coupled with apps and clinician portals facilitates secondary prevention post-stroke, enabling remote monitoring, goal-setting, and intervention for better long-term outcomes.
- 53:11 Co-designed solutions considering context and community impact are crucial for improving stroke care from prehospital to long-term management, with a focus on gender-specific treatments and routine monitoring.