I could site numerous studies that show that doses of more than once weekly drive-up hematocrit levels because of the half-life of the drug adding up. In point of fact studies have shown that weekly doses raise hematocrit more than dosing every two weeks. I won't bother to site the studies as I doubt seriously if you could read them.
As for keeping levels constantly stable this is not how the body works. The body constantly has highs and lows and actually works best when this is duplicated. Why do you think you must get a
testosterone test before 8am for it to be accurate? Because it is high in the morning and low at night. However, with all this being said, I would recommend you take hourly doses, keep your total testosterone around 2000ng/dl and consult with the people with no training at all on the internet forums!
I could site numerous studies that show that doses of more than once weekly drive-up hematocrit levels because of the half-life of the drug adding up. In point of fact studies have shown that weekly doses raise hematocrit more than dosing every two weeks. I won't bother to site the studies as I doubt seriously if you could read them.
LOL post em up!
The site is loaded with studies, lectures, interviews with some of the top-experts in the field and no we are not talking just endos here LMFAO!
Listen closely
34:04-49:36
Only at Nelson's domain. Enjoyed this one. Dr. Khera and Dr. Mulhalll, are two giants in the field here!
www.excelmale.com
This is only one of many webinars with some of the top in the field stating how they switch their patients over from once weekly to twice weekly injections in order to clip the peak--->trough let alone maintain more stable/reasonable blood levels throughout the week which will have a big impact on hematocrit.
Still caught up on that peak--->trough LOL!
No one told you it is not just about the peak--->trough/how high you drive up your peak T but more importantly how high you run your FT level at steady-state!
Yes one can inject more frequently using lower weekly doses and easily bring down their FT steady-state let alone clip the peak--->trough which can bring down the hematocrit!
Whether injecting once weekly, twice-weekly, every 3.5 days, 3X weekly, EOD or daily one can easily lower their peak T let alone trough by simply lowering their weekly dose and bringing down their FT peak/steady-state plain and simple!
Big difference in peak--->trough injecting once weekly vs EOD or daily!
No one in the know is prescribing those old outdated piss poor protocols 200 mg T every 2 weeks.
Injecting 200 mg esterified TC/TE every 2 weeks to treat low-t symptoms let alone long-term is a horrible protocol due to the PKs.
Very few men would reap the full beneficial effects of having healthy FT levels on such protocols due to the extreme swing in hormones.
It is a given that you would be back to being hypogonadal before the 2 week mark on such protocol.
You clearly lack the understanding of the PKs/half-lifes and again TE/TC are basically interchangeable!
Better throw this in here too seeing as you are clueless.
Regarding those struggling with high hematocrit here is my reply from another thread:
As you can see your RBCs/hemoglobin/hematocrit is elevated which is a common side-effect when using exogenous T, especially when running higher FT levels let alone peak--->trough levels can have a significant impact.
When using exogenous T RBCs, hemoglobin and hematocrit will increase within the 1st month and can take anywhere from 6-12 months to reach peak levels.
T formulation, the dose of T, genetics (polymorphism of the AR), age all play a role in the impact a trt protocol will have on blood markers (RBCs/hemoglobin/hematocrit).
Other factors such as sleep apnea, smoking, asthma, COPD can have a negative impact on hematocrit.
Injectable T has been shown to have a greater impact on increasing HCT compared to transdermal T.
3–18% with transdermal administration and up to 44% with injection.
In most cases when using injectable T
high supra-physiological peaks post-injection and overall T levels (running too high TT/FT level) steady-state will have a big impact on increasing HCT.
Manipulating injection frequency by injecting more frequently using lower doses of T resulting in minimizing the peak--->trough and maintaining more stable levels may lessen the impact on HCT but it is not a given as many men still end up running too high a FT level steady-state!
As again running very high TT/FT levels will have a stronger impact on driving up HCT.
Although injectables have been shown to have a greater impact on HCT you can see even when using a transdermal formulation that maintains stable serum concentrations that
the impact it has on HCT is DEPENDANT ON THE DOSE AND SERUM LEVEL OF T.
Using higher doses of transdermal T and achieving higher TT/FT levels will have a greater impact on HCT levels.
How high an FT level you are running is critical.
It is a given that most men on trt struggling with elevated RBCs/hemoglobin/hematocrit are
running too high an FT level.
Sure some men are more sensitive than others as they may still struggle with elevated blood markers when running lower T levels but it is far from common and many may already have an underlying health issue contributing to such.
If you are struggling with such blood markers then in most cases finding the
lowest FT level you can run while still maintaining the beneficial effects may very well be the solution.
Easier said than done as many men on trt tend to do better running higher-end FT levels within reason.
Mind you some are lucky and never have an issue or levels tend to stabilize over time.
Others will continue to struggle until the cows come home.
Unfortunately too many are caught up in running absurdly high trough FT levels due to the herd mentality spewed on the bro forums and gootube!
As for keeping levels constantly stable this is not how the body works. The body constantly has highs and lows and actually works best when this is duplicated. Why do you think you must get a testosterone test before 8am for it to be accurate? Because it is high in the morning and low at night. However, with all this being said, I would recommend you take hourly doses, keep your total testosterone around 2000ng/dl and consult with the people with no training at all on the internet forums!
No shit sherlock!
Natural endogenous testosterone secretion is pulsatile and diurnal.
During the natural 24-hour circadian rhythm of a healthy young male T levels will start rising gradually overnight reaching a peak (highest point) in the early AM followed by lower levels in the late afternoon and reaching trough (lowest point) in the evening.
Fluctuations from peak--->trough would be around 20-25%
One daily peak/trough.
Many fail to realize that T levels gradually rise overnight reaching a peak in the early AM.
*elevated and near peak TT level during nighttime sleep, peak TT level around the time of morning awakening
*T production occurs in the greatest amount during sleep as recurring pulses at approximately 90 min intervals in healthy young males and approximately 140 min in healthy middle-aged males (91).
This is key:
(i) elevated and near peak TT level during nighttime sleep, (ii) peak TT level around the time of morning awakening, (iii) moderately elevated TT level during the initial hours of wakefulness, (iv) reduced TT level in the late afternoon, and (v) lowest TT level in the evening. Based upon these criteria, only the Androderm® transdermal patch (Figure 3D), when applied in the evening (∼22:00 h) as recommended, closely mimics the TT circadian rhythm of normal young adult males.
*There are substantial differences between the therapies in the derived TT 24 h pattern; moreover, all but one of them differs either somewhat or greatly from the normative one of diurnally active young adult males, which is defined by:
(i) elevated and near peak TT level during nighttime sleep, (ii) peak TT level around the time of morning awakening, (iii) moderately elevated TT level during the initial hours of wakefulness, (iv) reduced TT level in the late afternoon, and (v) lowest TT level in the evening. Based upon these criteria, only the Androderm® transdermal patch (Figure 3D), when applied in the evening (∼22:00 h) as recommended, closely mimics the TT circadian rhythm of normal young adult males.
*The Jatenzo® oral soft gel capsule formulation ingested twice daily at equal intervals also gives rise to variable TT levels of distinct 12 h patterning, with prominent Cmax following 2 to 4 h after each ingestion and rapidly declining levels thereafter (Figure 3B).
*As shown in the graphs of Figures 2 and 3, the PK of most FDA-approved PA-TRTs gives rise to TT 24-hour patterns that deviate greatly from the normative one thereby failing to satisfy one or more of the five specified criteria.
*The temporal patterns of these PA-TRTs differ from normal, either in the timing of the peak and/or nadir TT concentrations, by achieving the highest hormone levels generally between midmorning and noon and lowest (rather than near peak) ones during sleep (Figure 2A-2F).
Hate to burst your bubble here but the closest one would even ever mimic such is using the T patch (Androderm) applied before bed!
It was recently pulled off the market.
Wonder why!
No one would even waste their time using it as many could never even achieve a high enough FT level to derive the full beneficial effects of T let alone there are many other formulations which are far superior in many ways!
Does Patient-Applied Testosterone Replacement Therapy Pose Risk for Blood Pressure Elevation? Circadian Medicine Perspectives (2022) Michael H. Smolensky, Ramon C. Hermida, Linda Sackett-Lundeen, *Ramon G. Hermida-Ayala, and Yong-Jian Geng ABSTRACT We reviewed medication package inserts, US...
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No “hack”, but you should generally try for the lowest effective dose, same with pretty much everything else. Only HCG protocols I’ve had are 500 ius twice/week, 300 ius three times/week, and 250 ius three times/week. 250 three times/week is the best one I’ve found and I plan to stay there...
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Testosterone cypionate, eod. I seem to feel best between 7-800. I've been over 1,000, and didn't feel "better".
www.excelmale.com
However, with all this being said, I would recommend you take hourly doses, keep your total testosterone around 2000ng/dl and consult with the people with no training at all on the internet forums!
You tell em CHAMP!
We have some bright beautiful minds on Excel that are light years ahead of those Endos nutsacks you cling too!
