High reverse T3 the cause of high SHBG?

[Gman86]

Did you have morning/nocturnal wood with a high Shbg? I don’t but then idk if that’s the problem

I can’t remember about morning wood way back then unfortunately. I do remember never really having any sexual issues, when my T was low tho. My issues were more energy, mood, brain fog, and just feeling super unmotivated and very blah, and irritable, from what I can remember

SHBG won’t negatively affect sexual function, as long as u get ur free T up, from my understanding. U actually want SHBG to be moderate to high, imo. Just again, as long as u can concurrently have healthy free T levels

 

[RobRoy]

Ya I think a lot of people are starting to realize that receptor sensitivity plays a big role in how people do taking exogenous compounds, and how well they do with certain levels of endogenous hormones, as well, I would assume. I think the whole insulin sensitivity stuff has really opened people’s eyes to this concept. Everyone knows insulin sensitivity/ insensitivity is a real thing, and insulin receptors can’t be the only receptors that this can happen to. I would assume it can happen to any receptor on a cell.

I’ve been watching a lot of this guys vids lately. He has really really good info, imo. And he firmly believes that a guy taking exogenous test will need higher serum levels to get the same benefits as other men do with lower, but endogenous, levels. Aka a guy on trt might need a total of 1000, to feel similar to a guy that’s natural with a total of say 500-700, for example. Is he right? Idk lol. He could be. He believes it tho, and he’s got a good grasp on HRT, imo, and has the advantage of having helped thousands of clients over the past 10 years or so

https://m.youtube.com/@CortexLabsChannel/videos

He is literally an absolute idiot.

 

[Gman86]

He is literally an absolute idiot.

What makes u say that? He seems like he’s got a good grasp of things, from what I’ve seen.

 

[RobRoy]

What makes u say that? He seems like he’s got a good grasp of things, from what I’ve seen.

He literally doesn't know what he doesn't know. He provides so much misinformation but you have to know the information to know the misinformation. A lot of men unfortunately, like yourself get sucked in to his marketing. What do you think he has a good grasp on? He is an abstract surfer and presents baseline observations and not studies that actually prove causation. He suffers from severe confirmational bias and belief perseverance, and what he presents are not studies at all that supports what he's trying to say but the casual observer doesn't understand that.

 

[apsjiml]

My SHBG is high. I believe I ruled out all other causes of high SHBG- sensitive e2 is on the lower end of normal, increased my Vitamin D to well over 100, natural testosterone is 8-900, and DHT is normal.

Last cause is thyroid.
Comprehensive thyroid panel was good except for a very high reverse T3. So being that T4 and T3 are normal, there’s technically extra thyroid circulating in reverse T3.

I know that reverse T3 is considered opposing, but maybe it doesn’t matter when the body/liver noticed

My SHBG is high. I believe I ruled out all other causes of high SHBG- sensitive e2 is on the lower end of normal, increased my Vitamin D to well over 100, natural testosterone is 8-900, and DHT is normal.

Last cause is thyroid.
Comprehensive thyroid panel was good except for a very high reverse T3. So being that T4 and T3 are normal, there’s technically extra thyroid circulating in reverse T3.

I know that reverse T3 is considered opposing, but maybe it doesn’t matter when the body/liver noticed it and makes extra SHBG?

Reverse t3 is made from t4, it is a way for the body to get rid of excess t4. Free t3 on a standard lab test, the interference on that test is binding globulins and antibodies. So, thyroid patients that is not necessarily accurate to do a standard free t3 test. If reverse t3 is high then likely free t3 is actually low. You need to do a free t3 dialysis test. I know walk in labs does that , request a test about $100. How reliable are free thyroid and total T3 hormone assays?

 

[apsjiml]

My SHBG is high. I believe I ruled out all other causes of high SHBG- sensitive e2 is on the lower end of normal, increased my Vitamin D to well over 100, natural testosterone is 8-900, and DHT is normal.

Last cause is thyroid.
Comprehensive thyroid panel was good except for a very high reverse T3. So being that T4 and T3 are normal, there’s technically extra thyroid circulating in reverse T3.

I know that reverse T3 is considered opposing, but maybe it doesn’t matter when the body/liver noticed it and makes extra SHBG?

SHBG is a separate but often times Thyroid Binding Globulin is high as well. SHBG rising when a persons testosterone is low is a way for the body to hold on to more testosterone. High shbg means testosterone will stay in the body longer so total t will be higher. Free testosterone is not as accurate with high shbg like that. High shbg means the body is also holding on to free testosterone making that less available. The cause could just be a guy having low testosterone. My dads was 125 shbg before he got on testosterone, then it went down once he was on. I know tons of people on t3 only and higher dosages that do not have high shbg so thyroid replacement does not necessarily mean you will have high shbg