Contrary to the popular trend here on the forums, high E2 can cause a myriad of issues. I’m an absolute basket case if my E2 gets over 40-45. I’m talking completely impotent, panic attacks, zero libido, etc. Dr. Saya and I target my E2 between 25-30 which seems to be the sweet spot for me. All the fear mongering about AIs aside, I take 0.125mg of anastrazole 4x per week. It’s what works for me…. I am thrilled that some men can seem to get by with their E2 at twice those numbers, but it simply doesn’t work for everyone and I’m an example of that.