Hand numbness/Anxiety - E2?

[CKO]

I'm hoping to get some insight on why I experience tingling and hand numbness. It almost always occurs after using HCG and I've experienced it on my current protocol (below) as well as when I was on clomid + HCG. I also usually experience a marked increase in anxiety at the same time. I'm suspecting this is related to E2 and generally occurs for me when my estradiol is 40pg/ml (range 8-35, estradiol sensitive) or higher. When my estradiol labs come back in the 20s, I usually do not experience the hand numbness or anxiety.

Protocol: 140 cypionate (divided into 2x a week), 400 IU HCG x 2 week, 1/8 anastrozole x 2 week.

Recently, I've been using 1/8 anastrozole 3X a week and this has helped my symptoms. I also notice relief from the hand numbness and anxiety, 5 to 6 hours after taking an AI.

 

[S1W]

I don’t have an answer for you, but I have also experienced this. I asked about it in another forum and the responses seened to be split between those that thought it was due to high E2/water retention vs high HCT/circulation.

Interesting to note that the AI had an almost immediate effect for you. Thanks for sharing that.

 

[CKO]

My HCT has been around 46-47 for the past year. I'm assuming it's water retention. I did notice the numbness gets worse with increased sodium intake.

 

[Jrsjr]

I'm hoping to get some insight on why I experience tingling and hand numbness. It almost always occurs after using HCG and I've experienced it on my current protocol (below) as well as when I was on clomid + HCG. I also usually experience a marked increase in anxiety at the same time. I'm suspecting this is related to E2 and generally occurs for me when my estradiol is 40pg/ml (range 8-35, estradiol sensitive) or higher. When my estradiol labs come back in the 20s, I usually do not experience the hand numbness or anxiety.

Protocol: 140 cypionate (divided into 2x a week), 400 IU HCG x 2 week, 1/8 anastrozole x 2 week.

Recently, I've been using 1/8 anastrozole 3X a week and this has helped my symptoms. I also notice relief from the hand numbness and anxiety, 5 to 6 hours after taking an AI.

I use to get anxiety attacks, not from TRT, and my hand or hands would tingle and go numb. Turned out I was hyper ventilating by taking shallow quick breaths without realizing it during an attack. Not sure if this applies to your situation but hope it helps.

 

[sammmy]

Tingling and hand numbness are serious symptoms that should be examined by a doctor, not "explained" away by some high hormone. It usually indicates nerve damage, although the actual trigger for that is hard to find.

 

[CKO]

Thanks for the input. Yep, I discussed with my doc at Defy. Hand numbness/tingling started with trt/HCG and went away when I discontinued for a while. Very odd.