Gynecomastia, Male Breast Cancer, and Beyond

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Figure 19. Fibroadenoma in a 36-year-old transgender woman who underwent more than 4 years of estrogen hormone therapy and presented with a palpable breast mass. (A) Right MLO mammogram shows an oval partially circumscribed and partially obscured mass in the upper right breast (arrow), corresponding to the palpable lump (triangular-shaped skin marker). The breast is heterogeneously dense due to diffuse glandular gynecomastia, symmetric to the contralateral breast (not shown). (B) US image shows an oval, parallel, hypoechoic mass with circumscribed margins (arrow) and mild posterior acoustic enhancement (arrowhead).(C) Photomicrograph of the core needle biopsy specimen shows stromal proliferation with fibromyxoid changes (short arrows) and associated ductal proliferation (long arrows), consistent with a fibroadenoma. (H-E stain;original magnification, ×10.)
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