Factors that May Decrease Estradiol in Men on Testosterone

[Nelson Vergel]

Factors that decrease estradiol:

1- Current or past use of aromatase inhibitors like anastrozole.

2- High DHT
DHT is a powerful estrogen blocker

Anabolic steroids like oxandrolone are DHT analogs that can make estradiol go to undetectable levels. Some supplements that may contain unapproved DHT analogs may cause the same issue.

3- Genetics.

Some men have aromatase deficiency

https://www.nejm.org/doi/full/10.1056/nejm199707103370204

4- Certain foods (we have weak data on this)

Anti-Estrogen Diet for Men: Foods for Lowering Levels