Interesting, thanks for sharing! In my opinion, part of the reason people feel better on the cream is because of the high blood levels of testosterone, DHT, and varying degrees of metabolic dysfunction being one of the main reasons. 1/3 of the population has metabolic dysfunction which causes lethargy, inflammation and fatigue.... Metabolism is everything! I'm going to start a discussion on metabolic dysfunction. In my experience, Metformin combined with a 11B HSD1 inhibitor greatly improves my metabolism. If anything should be combined with metformin I think it should be a 11B HSD1 inhibitor as metformin increases tissue levels of this enzyme causing decreases in other metabolic parameters. There's of course many other aspects of metabolism I'll be bringing up.