Enclomiphene versus clomiphene study results

[Nelson Vergel]

Among 66 patients, enclomiphene exhibited a median testosterone increase of 166 (vs. 98 ng/dL, P=0.20) with lower estradiol change than clomiphene (–5.92 vs. 17.50 pg/mL, P=0.001). Adverse effects were statistically significantly less frequent with enclomiphene, including decreased libido (P=0.001), reduced energy (P=0.044), and mood changes (P=0.03). Regression analysis confirmed lower odds of adverse events with enclomiphene [OR: 0.18; 95% confidence interval (CI): 0.07–0.44, P=0.02].

Safety and efficacy of enclomiphene and clomiphene for hypogonadal men - Saffati - Translational Andrology and Urology

 

[Seagal]

Not randomized and see limitations.